MX9603171A - Derivados de carbamoilmetilurea. - Google Patents

Derivados de carbamoilmetilurea.

Info

Publication number
MX9603171A
MX9603171A MX9603171A MX9603171A MX9603171A MX 9603171 A MX9603171 A MX 9603171A MX 9603171 A MX9603171 A MX 9603171A MX 9603171 A MX9603171 A MX 9603171A MX 9603171 A MX9603171 A MX 9603171A
Authority
MX
Mexico
Prior art keywords
optionally substituted
receptors
cck
substituted phenyl
cycloalkyl
Prior art date
Application number
MX9603171A
Other languages
English (en)
Inventor
Sanji Hagishita
Susumu Kamata
Yasushi Murakami
Nobuhiro Haga
Yasunobu Ishihara
Toshiro Konoike
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of MX9603171A publication Critical patent/MX9603171A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invencion se refiere a un compuesto de la formula (I): en donde R1 es un átomo de hidrogeno o alquilo inferior; R2 es un alcoxi inferior, alquilamino inferior, cicloalquilo inferior, fenilo substituido opcionalmente o un grupo heterocíclico substituido opcionalmente; R3 es un fenilo substituido opcionalmente; R4 es un fenilo substituido opcionalmente, cicloalquilo substituido opcionalmente, alquilo substituido opcionalmente o un grupo heterocíclico substituido opcionalmente, o una sal del mismo aceptable farmacéuticamente, el cual tiene una alta afinidad hacia los receptores de la gastrina y/o hacia los receptores de la CCK-B pero no hacia los receptores de la CCK-A, y es util para tratar las enfermedades asociadas con los receptores de la gastrina y/o los receptores de la CCK-B sin inducir los efectos laterales asociados con los receptores de la CCK-A.
MX9603171A 1994-02-09 1995-02-07 Derivados de carbamoilmetilurea. MX9603171A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1518994 1994-02-09
JP24155594 1994-10-05
PCT/JP1995/000161 WO1995021856A1 (fr) 1994-02-09 1995-02-07 Derives du carbamoylmethyluree

Publications (1)

Publication Number Publication Date
MX9603171A true MX9603171A (es) 1997-03-29

Family

ID=26351304

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9603171A MX9603171A (es) 1994-02-09 1995-02-07 Derivados de carbamoilmetilurea.

Country Status (17)

Country Link
US (1) US5739162A (es)
EP (1) EP0739903B1 (es)
CN (1) CN1145074A (es)
AT (1) ATE212356T1 (es)
AU (1) AU691565B2 (es)
BR (1) BR9506763A (es)
CA (1) CA2181986A1 (es)
DE (1) DE69525145T2 (es)
ES (1) ES2171531T3 (es)
FI (1) FI963122A0 (es)
HU (1) HU219913B (es)
MX (1) MX9603171A (es)
NO (1) NO963307L (es)
PT (1) PT739903E (es)
RU (1) RU2134684C1 (es)
TW (1) TW294653B (es)
WO (1) WO1995021856A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
DE69615570T2 (de) * 1995-08-07 2002-07-11 Shionogi & Co Verfahren zur herstellung von carbamoylmethylharnstoff-derivaten
CA2917811C (en) * 2013-07-16 2021-08-31 Allergan, Inc. Derivatives of n-urea substituted amino acids as formyl peptide receptor modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166355A2 (en) * 1984-06-26 1986-01-02 Merck & Co. Inc. Substituted aminophenyl compounds and acylaminophenyl compounds and pharmaceutical compositions containing them
WO1991012264A1 (fr) * 1990-02-09 1991-08-22 Rhone-Poulenc Rorer S.A. N-phenyl n-acetamido glycinamides, leur preparation et les medicaments les contenant
FR2667864B2 (fr) * 1990-03-07 1994-08-05 Rhone Poulenc Sante Derives de n-phenyl glycinamides, leur preparation et les medicaments les contenant.
FR2659334B1 (fr) * 1990-03-07 1992-05-15 Rhone Poulenc Sante Derives de n-phenyl glycinamide, leur preparation et les medicaments les contenant.
FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.

Also Published As

Publication number Publication date
FI963122A (fi) 1996-08-09
DE69525145D1 (en) 2002-03-14
CN1145074A (zh) 1997-03-12
NO963307D0 (no) 1996-08-08
HUT74950A (en) 1997-03-28
EP0739903A4 (en) 1998-07-08
NO963307L (no) 1996-10-09
RU2134684C1 (ru) 1999-08-20
DE69525145T2 (de) 2002-08-29
TW294653B (es) 1997-01-01
HU9602187D0 (en) 1996-10-28
FI963122A0 (fi) 1996-08-09
EP0739903B1 (en) 2002-01-23
ES2171531T3 (es) 2002-09-16
WO1995021856A1 (fr) 1995-08-17
EP0739903A1 (en) 1996-10-30
ATE212356T1 (de) 2002-02-15
HU219913B (hu) 2001-09-28
BR9506763A (pt) 1997-10-07
AU691565B2 (en) 1998-05-21
AU1590595A (en) 1995-08-29
CA2181986A1 (en) 1995-08-17
US5739162A (en) 1998-04-14
PT739903E (pt) 2002-05-31

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