MX9306676A - Modificaciones a la somatotropina. - Google Patents
Modificaciones a la somatotropina.Info
- Publication number
- MX9306676A MX9306676A MX9306676A MX9306676A MX9306676A MX 9306676 A MX9306676 A MX 9306676A MX 9306676 A MX9306676 A MX 9306676A MX 9306676 A MX9306676 A MX 9306676A MX 9306676 A MX9306676 A MX 9306676A
- Authority
- MX
- Mexico
- Prior art keywords
- somatotropins
- modifications
- histidine
- glutamic acid
- acid replaces
- Prior art date
Links
- 238000012986 modification Methods 0.000 title abstract 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 2
- 235000013922 glutamic acid Nutrition 0.000 abstract 2
- 239000004220 glutamic acid Substances 0.000 abstract 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 2
- 230000004048 modification Effects 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical group OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000282887 Suidae Species 0.000 abstract 1
- 210000000577 adipose tissue Anatomy 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 abstract 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000002741 site-directed mutagenesis Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97109892A | 1992-10-28 | 1992-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9306676A true MX9306676A (es) | 1994-04-29 |
Family
ID=25517926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9306676A MX9306676A (es) | 1992-10-28 | 1993-10-27 | Modificaciones a la somatotropina. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0669939A1 (fr) |
| JP (1) | JPH08502963A (fr) |
| AU (1) | AU5142293A (fr) |
| CA (1) | CA2145546A1 (fr) |
| MX (1) | MX9306676A (fr) |
| WO (1) | WO1994010200A1 (fr) |
| ZA (1) | ZA936811B (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2334580B (en) * | 1997-11-14 | 2002-12-18 | Generic Biolog Ltd | Improvements in or relating to detection of exogenously administered polypeptides |
| GB9723955D0 (en) | 1997-11-14 | 1998-01-07 | Generic Biolog Limited | Improvements in or relating to detection of molecules in samples |
| US6844322B2 (en) | 2000-07-21 | 2005-01-18 | Monsanto Technology Llc | Method for induced lactation |
| CN102112157B (zh) | 2008-08-06 | 2013-05-29 | 诺沃-诺迪斯克保健股份有限公司 | 具有延长的体内效能的缀合蛋白 |
| TWI504405B (zh) | 2009-01-22 | 2015-10-21 | Novo Nordisk Healthcare Ag | 穩定的生長激素化合物 |
| US8841249B2 (en) | 2009-08-06 | 2014-09-23 | Novo Nordisk A/S | Growth hormones with prolonged in-vivo efficacy |
| CN102834109B (zh) | 2010-01-22 | 2016-01-20 | 诺沃—诺迪斯克保健股份有限公司 | 稳定的生长激素化合物 |
| RU2012134974A (ru) | 2010-01-22 | 2014-02-27 | Ново Нордиск Хелс Кеа Аг | Стабилизированное соединение гормона роста |
| CN103596972B (zh) * | 2011-06-10 | 2018-03-20 | 诺沃—诺迪斯克有限公司 | 多肽 |
| JP6464145B2 (ja) | 2013-04-05 | 2019-02-06 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 成長ホルモン化合物製剤 |
| WO2015070911A1 (fr) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Séquence d'endolysine kz144 modifiée |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68929273T2 (de) * | 1988-08-24 | 2001-07-05 | American Cyanamid Co | Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung |
| WO1990008164A1 (fr) * | 1989-01-19 | 1990-07-26 | The Upjohn Company | Analogues de somatotrophine |
| KR927003633A (ko) * | 1989-07-10 | 1992-12-18 | 로버트 에이. 아미테이지 | 소마토트로핀 유사체 |
| US5310882A (en) * | 1990-11-30 | 1994-05-10 | American Cyanamid Company | Somatotropins with alterations in the α-helix 3 region |
-
1993
- 1993-09-15 ZA ZA936811A patent/ZA936811B/xx unknown
- 1993-10-04 CA CA002145546A patent/CA2145546A1/fr not_active Abandoned
- 1993-10-04 AU AU51422/93A patent/AU5142293A/en not_active Abandoned
- 1993-10-04 EP EP93922424A patent/EP0669939A1/fr not_active Ceased
- 1993-10-04 JP JP6511061A patent/JPH08502963A/ja active Pending
- 1993-10-04 WO PCT/US1993/009232 patent/WO1994010200A1/fr not_active Application Discontinuation
- 1993-10-27 MX MX9306676A patent/MX9306676A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA936811B (en) | 1995-03-15 |
| EP0669939A1 (fr) | 1995-09-06 |
| WO1994010200A1 (fr) | 1994-05-11 |
| CA2145546A1 (fr) | 1994-05-11 |
| JPH08502963A (ja) | 1996-04-02 |
| AU5142293A (en) | 1994-05-24 |
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