MX9303490A - Proceso para preaparar (1'r.3s 4r) 4-aciltio-azetidinonas. - Google Patents
Proceso para preaparar (1'r.3s 4r) 4-aciltio-azetidinonas.Info
- Publication number
- MX9303490A MX9303490A MX9303490A MX9303490A MX9303490A MX 9303490 A MX9303490 A MX 9303490A MX 9303490 A MX9303490 A MX 9303490A MX 9303490 A MX9303490 A MX 9303490A MX 9303490 A MX9303490 A MX 9303490A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- chem
- compound
- azetidinonas
- aciltio
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001768 cations Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- HHXMXAQDOUCLDN-RXMQYKEDSA-N penem Chemical compound S1C=CN2C(=O)C[C@H]21 HHXMXAQDOUCLDN-RXMQYKEDSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052710 silicon Chemical group 0.000 abstract 1
- 239000010703 silicon Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
En la presente invención se proporciona un proceso para preparar un compuesto de fórmula (I), en donde R es H o un grupo protector de hidroxi, R2 es un residuo orgánico y R3 es H o un grupo protector de nitrógeno, proceso que comprende hacer reaccionar juntos un compuestos de la fórmula (II), en donde R1 es un alquilo de 1 a 4 átomos de carbono o un grupo fenilo, R y R3 son como se definieron anteriormente un compuesto de la fórmula (III), en donde R2 es como se definión anteriormente, y X es un catión o un residuo que contiene silicio, y una sal de un elemento del grupo IIa, IIb o de un elemento de transición. Los compuestos de fórmula (I) son compuestos intermedios en la síntesis de los antibióticos penem.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929212707A GB9212707D0 (en) | 1992-06-16 | 1992-06-16 | 4-acylthio azetidiones |
| GB929226292A GB9226292D0 (en) | 1992-12-17 | 1992-12-17 | (1,3,3s,4r)4-acylthio azetidinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9303490A true MX9303490A (es) | 1994-08-31 |
Family
ID=26301073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9303490A MX9303490A (es) | 1992-06-16 | 1993-06-11 | Proceso para preaparar (1'r.3s 4r) 4-aciltio-azetidinonas. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5399679A (es) |
| EP (1) | EP0574784B1 (es) |
| JP (1) | JPH06509818A (es) |
| CN (1) | CN1081668A (es) |
| AT (1) | ATE210115T1 (es) |
| AU (1) | AU666559B2 (es) |
| CA (1) | CA2115173A1 (es) |
| DE (1) | DE69331249T2 (es) |
| ES (1) | ES2169031T3 (es) |
| FI (1) | FI940679A (es) |
| HU (1) | HUT70492A (es) |
| IL (1) | IL105975A0 (es) |
| MX (1) | MX9303490A (es) |
| TW (1) | TW239123B (es) |
| WO (1) | WO1993025523A1 (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8321677D0 (en) * | 1983-08-11 | 1983-09-14 | Erba Farmitalia | Preparation of penems |
| EP0215739B1 (de) * | 1985-09-11 | 1993-09-01 | Ciba-Geigy Ag | Synthese von Beta-Lactamverbindungen |
| US4782145A (en) * | 1986-06-02 | 1988-11-01 | Pfizer Inc. | Process for penem derivatives |
| GB8713515D0 (en) * | 1987-06-10 | 1987-07-15 | Erba Farmitalia | Methoxymethyl compounds |
| GB9006114D0 (en) * | 1990-03-19 | 1990-05-16 | Erba Carlo Spa | Process for preparing penem esters |
-
1993
- 1993-04-30 US US08/054,233 patent/US5399679A/en not_active Expired - Fee Related
- 1993-06-07 EP EP93109103A patent/EP0574784B1/en not_active Expired - Lifetime
- 1993-06-07 DE DE69331249T patent/DE69331249T2/de not_active Expired - Fee Related
- 1993-06-07 ES ES93109103T patent/ES2169031T3/es not_active Expired - Lifetime
- 1993-06-07 AT AT93109103T patent/ATE210115T1/de not_active IP Right Cessation
- 1993-06-10 IL IL105975A patent/IL105975A0/xx unknown
- 1993-06-11 MX MX9303490A patent/MX9303490A/es unknown
- 1993-06-11 TW TW082104642A patent/TW239123B/zh active
- 1993-06-14 WO PCT/EP1993/001495 patent/WO1993025523A1/en active Application Filing
- 1993-06-14 CA CA002115173A patent/CA2115173A1/en not_active Abandoned
- 1993-06-14 HU HU9400431A patent/HUT70492A/hu unknown
- 1993-06-14 JP JP6501130A patent/JPH06509818A/ja active Pending
- 1993-06-14 AU AU43255/93A patent/AU666559B2/en not_active Ceased
- 1993-06-14 CN CN93107291A patent/CN1081668A/zh active Pending
-
1994
- 1994-02-14 FI FI940679A patent/FI940679A/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993025523A1 (en) | 1993-12-23 |
| AU4325593A (en) | 1994-01-04 |
| DE69331249D1 (de) | 2002-01-17 |
| IL105975A0 (en) | 1993-10-20 |
| HU9400431D0 (en) | 1994-05-30 |
| ES2169031T3 (es) | 2002-07-01 |
| US5399679A (en) | 1995-03-21 |
| CN1081668A (zh) | 1994-02-09 |
| CA2115173A1 (en) | 1993-12-23 |
| DE69331249T2 (de) | 2002-06-13 |
| FI940679A0 (fi) | 1994-02-14 |
| TW239123B (es) | 1995-01-21 |
| EP0574784A1 (en) | 1993-12-22 |
| HUT70492A (en) | 1995-10-30 |
| FI940679A (fi) | 1994-02-14 |
| JPH06509818A (ja) | 1994-11-02 |
| ATE210115T1 (de) | 2001-12-15 |
| AU666559B2 (en) | 1996-02-15 |
| EP0574784B1 (en) | 2001-12-05 |
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