MX9302503A - Sulfitos y sulfatos ciclicos de fructopiranosa anticonvulsivos. - Google Patents
Sulfitos y sulfatos ciclicos de fructopiranosa anticonvulsivos.Info
- Publication number
- MX9302503A MX9302503A MX9302503A MX9302503A MX9302503A MX 9302503 A MX9302503 A MX 9302503A MX 9302503 A MX9302503 A MX 9302503A MX 9302503 A MX9302503 A MX 9302503A MX 9302503 A MX9302503 A MX 9302503A
- Authority
- MX
- Mexico
- Prior art keywords
- fructopyranose
- anticonvulsive
- sulphites
- cyclic sulphates
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Detergent Compositions (AREA)
- Compounds Of Unknown Constitution (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Optical Radar Systems And Details Thereof (AREA)
- Treating Waste Gases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de la siguiente fórmula (I): en donde R1, R2, R3, R4, R5, R6, n y p son como se define aquí, poseen actividad anticonvulsiva en mamíferos y, por lo tanto, son útiles en el tratamiento de alteraciones del sistema nervioso central, tales como la epilepsia. Los compuestos de la fórmula (I) también son útiles para tratar glaucoma y úlcera pépticas. Además, los compuestos de la fórmula (I) son diuréticos, por lo cual son útiles en el tratamiento de la hipertensión, de fallas cardiacas congestivas y de otros tipos de edemas. Las presente invención comprende los compuestos de la fórmula (I), las composiciones farmacéuticas que contienen uno o más de los compuestos de la fórmula (I) y los métodos para el tratamiento o prevención de convulsiones, úlceras pépticas, glaucoma, hipertensión, fallas cardiacas congestivas y otros tipos de edemas, utilizando dichos compuestos. Los compuestos útiles como intermediarios para preparar los compuestos de la fórmula (I) también están incluidos en esta invención.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/874,875 US5242942A (en) | 1992-04-28 | 1992-04-28 | Anticonvulsant fructopyranose cyclic sulfites and sulfates |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9302503A true MX9302503A (es) | 1994-05-31 |
Family
ID=25364769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9302503A MX9302503A (es) | 1992-04-28 | 1993-04-28 | Sulfitos y sulfatos ciclicos de fructopiranosa anticonvulsivos. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5242942A (es) |
EP (1) | EP0568306B1 (es) |
JP (1) | JP3356324B2 (es) |
AT (1) | ATE145914T1 (es) |
AU (1) | AU658287B2 (es) |
CA (1) | CA2094859C (es) |
DE (1) | DE69306298T2 (es) |
DK (1) | DK0568306T3 (es) |
ES (1) | ES2097448T3 (es) |
FI (1) | FI109700B (es) |
MX (1) | MX9302503A (es) |
NO (1) | NO180011C (es) |
NZ (1) | NZ247468A (es) |
SG (1) | SG64296A1 (es) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5258402A (en) | 1992-06-11 | 1993-11-02 | Mcneil-Ppc, Inc. | Imidate derivatives of pharmaceutically useful anticonvulsant sulfamates |
US5384327A (en) * | 1992-12-22 | 1995-01-24 | Mcneilab, Inc. | Anticonvulsant sorbopyranose sulfamates |
NZ277725A (en) * | 1993-12-23 | 1998-04-27 | Ortho Pharma Corp | Pseudofructopyranose sulphamate derivatives, preparation and pharmaceutical compositions thereof |
US5998380A (en) * | 1995-10-13 | 1999-12-07 | New England Medical Center Hospitals, Inc. | Treatment of migraine |
ES2184127T3 (es) * | 1996-06-28 | 2003-04-01 | Ortho Mcneil Pharm Inc | Derivados de sulfamato anticonvulsivos utiles para el tratamiento de la obesidad. |
WO2000050020A2 (en) | 1999-02-24 | 2000-08-31 | University Of Cincinnati | Use of sulfamate derivatives for treating impulse control disorders |
US6583172B1 (en) * | 1999-04-08 | 2003-06-24 | Richard P. Shank | Anticonvulsant derivatives useful in treating chronic neurodegenerative disorders |
CA2369091C (en) * | 1999-04-08 | 2005-01-11 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful in lowering blood pressure |
US7056890B2 (en) | 1999-06-14 | 2006-06-06 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
US7659256B2 (en) * | 1999-06-14 | 2010-02-09 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
US7674776B2 (en) * | 1999-06-14 | 2010-03-09 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
US20080103179A1 (en) * | 2006-10-27 | 2008-05-01 | Tam Peter Y | Combination Therapy |
US7553818B2 (en) * | 1999-06-14 | 2009-06-30 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
US20080255093A1 (en) * | 1999-06-14 | 2008-10-16 | Tam Peter Y | Compositions and methods for treating obesity and related disorders |
US6495523B1 (en) * | 1999-07-26 | 2002-12-17 | Ortho Mcneil-Pharmaceutical, Inc. | Tricyclic monosaccharide derivatives useful in treating acute ischemia-induced neurodegeneration |
CN101404993A (zh) * | 2000-07-07 | 2009-04-08 | 奥索-麦克尼尔药品公司 | 用于预防ii型糖尿病和x综合征的发展的抗惊厥剂衍生物 |
AU2001280865A1 (en) | 2000-08-02 | 2002-02-13 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful for the treatment of depression |
AU2002253838B2 (en) * | 2000-10-30 | 2006-11-09 | Ortho-Mcneil Pharmaceutical, Inc. | Combination therapy comprising anti-diabetic and anticonvulsant agents |
KR100896971B1 (ko) * | 2001-02-02 | 2009-05-14 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 프락토피라노오스 설파메이트 및 에리트로포이에틴을포함하는 신경계 기능장애 치료법 |
UA78211C2 (en) * | 2001-07-09 | 2007-03-15 | Ortho Mcneil Pharm Inc | Salts of fructopyranose derivatives as anticonvulsant |
US7041650B2 (en) * | 2001-07-09 | 2006-05-09 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivative salts |
EP1450826A1 (en) * | 2001-11-06 | 2004-09-01 | Ortho-Mcneil Pharmaceutical Corp. | Treatment and prevention of paresthesia comprising co-therapy with anticonvulsant derivatives and potassium |
US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
US20100311701A1 (en) * | 2002-02-15 | 2010-12-09 | Transform Pharmaceuticals, Inc | Pharmaceutical Co-Crystal Compositions |
US20050025791A1 (en) * | 2002-06-21 | 2005-02-03 | Julius Remenar | Pharmaceutical compositions with improved dissolution |
US20090088443A1 (en) * | 2002-02-15 | 2009-04-02 | Julius Remenar | Novel crystalline forms of conazoles and methods of making and using the same |
US6559293B1 (en) | 2002-02-15 | 2003-05-06 | Transform Pharmaceuticals, Inc. | Topiramate sodium trihydrate |
WO2003074474A2 (en) | 2002-03-01 | 2003-09-12 | University Of South Florida | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
US7790905B2 (en) * | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
IL163720A0 (en) * | 2002-02-26 | 2005-12-18 | Ortho Mcneil Pharm Inc | Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents |
US7060725B2 (en) * | 2002-05-13 | 2006-06-13 | Janssen Pharmaceutica N.V. | Substituted sulfamate anticonvulsant derivatives |
US20070059356A1 (en) * | 2002-05-31 | 2007-03-15 | Almarsson Oern | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
US7196209B2 (en) * | 2002-10-31 | 2007-03-27 | Ortho-Mcneil Pharmaceutical, Inc. | Continuous process for the preparation of fructopyranose sulfamate derivatives |
US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
TW200612905A (en) * | 2004-06-16 | 2006-05-01 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
CA2578407A1 (en) * | 2004-08-24 | 2006-03-02 | Janssen Pharmaceutica N.V. | Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents |
EP1881959A1 (en) * | 2005-05-20 | 2008-01-30 | Janssen Pharmaceutica N.V. | Process for preparation of sulfamide derivatives |
EP1937646A1 (en) | 2005-09-23 | 2008-07-02 | Janssen Pharmaceutica N.V. | Tetrahydro-cyclopentyl pyrazole cannabinoid modulators |
NZ567006A (en) * | 2005-09-23 | 2010-11-26 | Janssen Pharmaceutica Nv | Hexahydro cyclooctyl pyrazole cannabinoid modulators |
US8378117B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
US7825151B2 (en) * | 2005-09-23 | 2010-11-02 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
US8378096B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
KR20080050522A (ko) * | 2005-09-23 | 2008-06-05 | 얀센 파마슈티카 엔.브이. | 헥사하이드로-사이클로헵타피라졸 카나비노이드 모듈레이터 |
US20070117858A1 (en) * | 2005-11-23 | 2007-05-24 | Mingde Xia | Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators |
US20070155824A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives for disease modification / epileptogenesis |
US20070155823A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents |
US8937096B2 (en) | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
US8691867B2 (en) * | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
US8716231B2 (en) | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
US8497298B2 (en) * | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
US20070155827A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression |
US8492431B2 (en) * | 2005-12-19 | 2013-07-23 | Janssen Pharmaceutica, N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity |
WO2007092456A2 (en) * | 2006-02-03 | 2007-08-16 | Rolls-Royce Corporation | Gas turbine engine fuel system with fuel metering valve |
US7795294B2 (en) * | 2006-02-14 | 2010-09-14 | Janssen Pharmaceutica N.V. | Tetrahydro-2H-indazole pyrazole cannabinoid modulators |
US20070191449A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression |
US20070191451A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of benzo-heteroaryl sulfamide derivatives as neuroprotective agents |
US20070191461A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine |
US20070191459A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels |
US20070191453A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of benzo-heteroaryl sulfamide derivatives for the treatment of substance abuse and addiction |
US20070191450A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Mania and Bipolar Disorder |
US20070191474A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine |
US20070191460A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Disease Modification / Epileptogenesis |
WO2007112402A1 (en) * | 2006-03-27 | 2007-10-04 | Janssen Pharmaceutica N.V. | Tetrahydro-1h-1,2,6-triaza-azulene cannabinoid modulators |
US20070254911A1 (en) * | 2006-03-27 | 2007-11-01 | Mingde Xia | Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators |
JP2009537635A (ja) * | 2006-05-19 | 2009-10-29 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 癲癇の処置のための共同−療法 |
US7943653B2 (en) * | 2007-08-13 | 2011-05-17 | Janssen Pharmaceutica N.V. | Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators |
US20090247617A1 (en) * | 2008-03-26 | 2009-10-01 | Abdel-Magid Ahmed F | Process for the preparation of benzo-fused heteroaryl sulfamates |
US8580298B2 (en) | 2008-06-09 | 2013-11-12 | Vivus, Inc. | Low dose topiramate/phentermine composition and methods of use thereof |
US20090304789A1 (en) | 2008-06-09 | 2009-12-10 | Thomas Najarian | Novel topiramate compositions and an escalating dosing strategy for treating obesity and related disorders |
BRPI0915890A2 (pt) | 2008-06-23 | 2015-11-03 | Janssen Pharmaceutica Nv | forma cristalina de (2s)-(-)-n-(6-cloro-2,3-di-hidro-benzo[1,4]dioxin-2-ilmetil)-sulfamida |
US8815939B2 (en) * | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
NL2021840B1 (en) | 2018-10-19 | 2020-05-13 | Univ Leiden | Pharmacological Chaperones For Enzyme Treatment Therapy |
WO2020046132A1 (en) | 2018-08-31 | 2020-03-05 | Leiden University | Pharmacological chaperones for enzyme treatment therapy |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2792398A (en) * | 1954-12-03 | 1957-05-14 | Miles Lab | Piperazine derivatives |
US3950393A (en) * | 1973-04-13 | 1976-04-13 | Boehringer Ingelheim Gmbh | Aminobenzyl-amides and salts thereof |
US3997585A (en) * | 1974-12-30 | 1976-12-14 | Ortho Pharmaceutical Corporation | Aliphatic sulfamates |
US4513006A (en) * | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
US4591601A (en) * | 1985-04-12 | 1986-05-27 | Mcneilab, Inc. | Anticonvulsant dioxolane methane sulfamates |
US4792569A (en) * | 1987-08-27 | 1988-12-20 | Mcneilab, Inc. | Anticonvulsant phenethyl sulfamates |
-
1992
- 1992-04-28 US US07/874,875 patent/US5242942A/en not_active Expired - Lifetime
-
1993
- 1993-04-21 NZ NZ247468A patent/NZ247468A/en not_active IP Right Cessation
- 1993-04-21 AU AU37073/93A patent/AU658287B2/en not_active Expired
- 1993-04-26 CA CA002094859A patent/CA2094859C/en not_active Expired - Lifetime
- 1993-04-27 NO NO931529A patent/NO180011C/no not_active IP Right Cessation
- 1993-04-27 DE DE69306298T patent/DE69306298T2/de not_active Expired - Lifetime
- 1993-04-27 SG SG1996001446A patent/SG64296A1/en unknown
- 1993-04-27 ES ES93303263T patent/ES2097448T3/es not_active Expired - Lifetime
- 1993-04-27 EP EP93303263A patent/EP0568306B1/en not_active Expired - Lifetime
- 1993-04-27 FI FI931888A patent/FI109700B/fi not_active IP Right Cessation
- 1993-04-27 DK DK93303263.3T patent/DK0568306T3/da active
- 1993-04-27 AT AT93303263T patent/ATE145914T1/de active
- 1993-04-27 JP JP12361193A patent/JP3356324B2/ja not_active Expired - Lifetime
- 1993-04-28 MX MX9302503A patent/MX9302503A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JPH07291988A (ja) | 1995-11-07 |
DK0568306T3 (da) | 1996-12-23 |
CA2094859A1 (en) | 1993-10-29 |
AU3707393A (en) | 1993-11-04 |
FI931888A (fi) | 1993-10-29 |
CA2094859C (en) | 2005-08-16 |
DE69306298D1 (de) | 1997-01-16 |
DE69306298T2 (de) | 1997-05-22 |
ES2097448T3 (es) | 1997-04-01 |
AU658287B2 (en) | 1995-04-06 |
NO931529D0 (no) | 1993-04-27 |
NO180011C (no) | 1997-01-29 |
SG64296A1 (en) | 1999-04-27 |
JP3356324B2 (ja) | 2002-12-16 |
NO931529L (no) | 1993-10-29 |
NZ247468A (en) | 1994-09-27 |
EP0568306B1 (en) | 1996-12-04 |
EP0568306A1 (en) | 1993-11-03 |
ATE145914T1 (de) | 1996-12-15 |
NO180011B (no) | 1996-10-21 |
FI931888A0 (fi) | 1993-04-27 |
FI109700B (fi) | 2002-09-30 |
US5242942A (en) | 1993-09-07 |
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