MX388593B - Regimenes y metodos de tratamiento de la esclerosis multiple usando ofatumumab. - Google Patents

Regimenes y metodos de tratamiento de la esclerosis multiple usando ofatumumab.

Info

Publication number
MX388593B
MX388593B MX2019001860A MX2019001860A MX388593B MX 388593 B MX388593 B MX 388593B MX 2019001860 A MX2019001860 A MX 2019001860A MX 2019001860 A MX2019001860 A MX 2019001860A MX 388593 B MX388593 B MX 388593B
Authority
MX
Mexico
Prior art keywords
regimen
ofatumumab
multiple sclerosis
methods
treatment
Prior art date
Application number
MX2019001860A
Other languages
English (en)
Spanish (es)
Other versions
MX2019001860A (es
Inventor
Weisskopf Algirdas Jonas Kakarieka
Erik Wallström
Joseph Michael Kahn
Praz Marina Savelieva
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2019001860A publication Critical patent/MX2019001860A/es
Publication of MX388593B publication Critical patent/MX388593B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pressure Welding/Diffusion-Bonding (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MX2019001860A 2016-08-15 2017-08-11 Regimenes y metodos de tratamiento de la esclerosis multiple usando ofatumumab. MX388593B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662374986P 2016-08-15 2016-08-15
PCT/IB2017/054909 WO2018033841A1 (en) 2016-08-15 2017-08-11 Regimens and methods of treating multiple sclerosis using ofatumumab

Publications (2)

Publication Number Publication Date
MX2019001860A MX2019001860A (es) 2019-07-08
MX388593B true MX388593B (es) 2025-03-20

Family

ID=59901554

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019001860A MX388593B (es) 2016-08-15 2017-08-11 Regimenes y metodos de tratamiento de la esclerosis multiple usando ofatumumab.

Country Status (24)

Country Link
US (5) US11161909B2 (enExample)
EP (5) EP4252847A3 (enExample)
JP (2) JP6851391B2 (enExample)
KR (2) KR20200136503A (enExample)
CN (5) CN120053639A (enExample)
AU (2) AU2017311664C1 (enExample)
CA (2) CA3101514A1 (enExample)
CY (1) CY1123350T1 (enExample)
DE (1) DE202017007542U1 (enExample)
DK (2) DK3733712T3 (enExample)
ES (2) ES2954259T3 (enExample)
FI (1) FI3733712T3 (enExample)
HR (2) HRP20230894T1 (enExample)
HU (2) HUE051948T2 (enExample)
IL (4) IL276890B2 (enExample)
LT (2) LT3497132T (enExample)
MX (1) MX388593B (enExample)
PL (2) PL3497132T3 (enExample)
PT (2) PT3497132T (enExample)
RS (2) RS64541B1 (enExample)
RU (1) RU2749951C2 (enExample)
SI (2) SI3497132T1 (enExample)
TW (1) TWI752995B (enExample)
WO (1) WO2018033841A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4252847A3 (en) 2016-08-15 2023-11-15 Novartis AG Regimens and methods of treating multiple sclerosis using ofatumumab
US20220389109A1 (en) * 2019-09-11 2022-12-08 Novartis Ag Management of conditions other than multiple sclerosis in ofatumumab-treated patients
JP7794735B2 (ja) 2019-09-11 2026-01-06 ノバルティス アーゲー 切替え療法によるｒｍｓの治療
WO2021204994A1 (en) * 2020-04-09 2021-10-14 Novartis Ag Ofatumumab for treating ms while maintaining serum igg
CN117529336A (zh) * 2021-04-14 2024-02-06 诺华股份有限公司 用于治疗亚洲患者的多发性硬化症的奥法木单抗
WO2026099463A1 (en) 2024-11-08 2026-05-15 Novartis Ag Glycoengineered anti-cd20 antibodies

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EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
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WO2015162504A1 (en) 2014-04-23 2015-10-29 Novartis Ag Novel dosing and uses of ofatumumab
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EP3250927B1 (en) * 2015-01-28 2020-02-19 H. Hoffnabb-La Roche Ag Gene expression markers and treatment of multiple sclerosis
CN106699886A (zh) 2015-07-13 2017-05-24 西藏海思科药业集团股份有限公司 抗体依赖性细胞介导的细胞毒性(adcc)增强的奥法木抗体
EP4252847A3 (en) 2016-08-15 2023-11-15 Novartis AG Regimens and methods of treating multiple sclerosis using ofatumumab
US20220389109A1 (en) 2019-09-11 2022-12-08 Novartis Ag Management of conditions other than multiple sclerosis in ofatumumab-treated patients
JP7794735B2 (ja) 2019-09-11 2026-01-06 ノバルティス アーゲー 切替え療法によるｒｍｓの治療
WO2021204994A1 (en) 2020-04-09 2021-10-14 Novartis Ag Ofatumumab for treating ms while maintaining serum igg
CN117529336A (zh) 2021-04-14 2024-02-06 诺华股份有限公司 用于治疗亚洲患者的多发性硬化症的奥法木单抗
JP2024531314A (ja) 2021-08-16 2024-08-29 ノバルティス アーゲー 小児ｍｓを治療するためのオファツムマブ

Also Published As

Publication number Publication date
TWI752995B (zh) 2022-01-21
AU2017311664A1 (en) 2019-01-31
IL276890B1 (en) 2023-06-01
WO2018033841A1 (en) 2018-02-22
KR20200136503A (ko) 2020-12-07
ES2821924T3 (es) 2021-04-28
FI3733712T3 (fi) 2023-08-22
AU2017311664C1 (en) 2025-05-22
EP4252847A2 (en) 2023-10-04
US11161909B2 (en) 2021-11-02
CN109641965A (zh) 2019-04-16
AU2020201112C1 (en) 2025-05-22
EP4252847A3 (en) 2023-11-15
US20240150485A1 (en) 2024-05-09
CA3101514A1 (en) 2018-02-22
HUE063625T2 (hu) 2024-01-28
DK3733712T3 (da) 2023-08-21
ES2954259T3 (es) 2023-11-21
EP4711008A2 (en) 2026-03-18
IL302488B1 (en) 2024-08-01
HRP20230894T1 (hr) 2023-11-24
IL276890A (en) 2020-10-29
RS60807B1 (sr) 2020-10-30
US12338290B2 (en) 2025-06-24
KR20190038914A (ko) 2019-04-09
CN120000782A (zh) 2025-05-16
LT3497132T (lt) 2020-10-12
US20190177424A1 (en) 2019-06-13
EP4711008A3 (en) 2026-06-03
US20250289902A1 (en) 2025-09-18
TW201808333A (zh) 2018-03-16
RU2019107146A (ru) 2020-09-15
CN120053638A (zh) 2025-05-30
IL313932A (en) 2024-08-01
DK3497132T3 (da) 2020-09-07
AU2020201112B2 (en) 2021-07-22
LT3733712T (lt) 2023-09-11
RU2021105514A3 (enExample) 2022-02-08
DE202017007542U1 (de) 2022-07-19
HUE051948T2 (hu) 2021-03-29
CN120037367A (zh) 2025-05-27
EP3733712B1 (en) 2023-05-24
US20220081488A1 (en) 2022-03-17
PL3733712T3 (pl) 2023-10-16
AU2020201112A1 (en) 2020-03-05
EP4371611A3 (en) 2024-07-24
PT3733712T (pt) 2023-08-31
MX2019001860A (es) 2019-07-08
AU2017311664B2 (en) 2020-01-02
US20240317878A1 (en) 2024-09-26
RU2019107146A3 (enExample) 2020-09-15
SI3497132T1 (sl) 2020-10-30
CA3030530A1 (en) 2018-02-22
CY1123350T1 (el) 2021-12-31
JP2020100630A (ja) 2020-07-02
CA3030530C (en) 2021-02-23
IL302488A (en) 2023-06-01
HRP20201388T1 (hr) 2020-11-27
PT3497132T (pt) 2020-09-25
SI3733712T1 (sl) 2023-12-29
PL3497132T3 (pl) 2020-11-30
IL264804B (en) 2020-09-30
IL276890B2 (en) 2023-10-01
EP3497132B1 (en) 2020-06-24
RU2021105514A (ru) 2021-04-19
EP4371611B1 (en) 2026-06-17
JP6851391B2 (ja) 2021-03-31
EP3497132A1 (en) 2019-06-19
IL302488B2 (en) 2024-12-01
CN120053639A (zh) 2025-05-30
RS64541B1 (sr) 2023-09-29
JP7198786B2 (ja) 2023-01-04
JP2019511506A (ja) 2019-04-25
EP4371611A2 (en) 2024-05-22
RU2749951C2 (ru) 2021-06-21
EP3733712A1 (en) 2020-11-04
US12570754B2 (en) 2026-03-10

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