MX385579B - Forma cristalina de gemcitabina. - Google Patents

Forma cristalina de gemcitabina.

Info

Publication number
MX385579B
MX385579B MX2018007782A MX2018007782A MX385579B MX 385579 B MX385579 B MX 385579B MX 2018007782 A MX2018007782 A MX 2018007782A MX 2018007782 A MX2018007782 A MX 2018007782A MX 385579 B MX385579 B MX 385579B
Authority
MX
Mexico
Prior art keywords
gemcitabine
crystalline form
alaninyl
benzoxy
phenyl
Prior art date
Application number
MX2018007782A
Other languages
English (en)
Other versions
MX2018007782A (es
Inventor
Hugh Griffith
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NuCana plc filed Critical NuCana plc
Publication of MX2018007782A publication Critical patent/MX2018007782A/es
Publication of MX385579B publication Critical patent/MX385579B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Esta invención se refiere a una forma cristalina de gemcitabina-[fenil-benzoxi-L-alaninil)]-(S)-fosfato.
MX2018007782A 2015-12-23 2016-12-21 Forma cristalina de gemcitabina. MX385579B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1522771.3A GB201522771D0 (en) 2015-12-23 2015-12-23 Crystalline form of a phosphate derivative
PCT/GB2016/054017 WO2017109485A1 (en) 2015-12-23 2016-12-21 Crystalline form of gemcitabine

Publications (2)

Publication Number Publication Date
MX2018007782A MX2018007782A (es) 2018-08-15
MX385579B true MX385579B (es) 2025-03-18

Family

ID=55311540

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018007782A MX385579B (es) 2015-12-23 2016-12-21 Forma cristalina de gemcitabina.

Country Status (13)

Country Link
US (1) US11377467B2 (es)
EP (1) EP3394077A1 (es)
JP (1) JP6840151B2 (es)
KR (1) KR20180096685A (es)
CN (1) CN108699099A (es)
AU (1) AU2016375860B2 (es)
BR (1) BR112018012943A2 (es)
CA (1) CA3008556A1 (es)
GB (1) GB201522771D0 (es)
HK (1) HK1255112A1 (es)
MX (1) MX385579B (es)
SG (1) SG11201805061YA (es)
WO (1) WO2017109485A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3235824T (pt) 2012-11-16 2019-05-30 NuCana plc Mistura de rp/sp gencitabina-[fenil-(benziloxi-l-alaninil)]-fosfato
AU2015278900B2 (en) 2014-06-25 2019-04-04 NuCana plc Formulation comprising a gemcitabine-prodrug
EP3757112B1 (en) 2014-06-25 2023-06-07 Nucana PLC Gemcitabine prodrugs
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
WO2017060661A1 (en) 2015-10-05 2017-04-13 Nucana Biomed Limited Combination therapy
HRP20211812T1 (hr) 2015-12-11 2022-03-04 NuCana plc Dijastereoselektivna sinteza derivata fosfata i prolijeka gemcitabina nuc-1031
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
FR2954310B1 (fr) 2009-12-18 2014-07-25 Univ Rouen Procede de dedoublement d'enantiomeres par evapocristallisation preferentielle
PT3235824T (pt) * 2012-11-16 2019-05-30 NuCana plc Mistura de rp/sp gencitabina-[fenil-(benziloxi-l-alaninil)]-fosfato
WO2014204856A1 (en) 2013-06-17 2014-12-24 Catabasis Pharmaceuticals, Inc. Fatty acid anticancer derivatives and their uses
MX2016006919A (es) 2013-11-27 2016-08-17 Idenix Pharmaceuticals Llc Nucleotidos para el tratamiento de cancer de higado.
EP3757112B1 (en) 2014-06-25 2023-06-07 Nucana PLC Gemcitabine prodrugs
AU2015278900B2 (en) 2014-06-25 2019-04-04 NuCana plc Formulation comprising a gemcitabine-prodrug
EP3172218B1 (en) 2014-07-22 2020-10-21 NuCana plc Process for the preparation of gemcitabine-[phenyl(benzoxy-l-alaninyl)] phosphate
GB201417644D0 (en) * 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
US9848863B2 (en) * 2015-02-25 2017-12-26 Globus Medical, Inc Surgical retractor systems and methods
WO2016181093A1 (en) 2015-05-14 2016-11-17 Nucana Biomed Limited Cancer treatments
CN106478753A (zh) * 2015-09-16 2017-03-08 博瑞生物医药（苏州）股份有限公司 一种nuc‑1031单一异构体的制备方法和用途
CN106543220A (zh) * 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 氨基磷酸酯化合物及其制备方法和晶体
CN106543252A (zh) * 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的制备方法及其中间体
WO2017060661A1 (en) 2015-10-05 2017-04-13 Nucana Biomed Limited Combination therapy
HRP20211812T1 (hr) 2015-12-11 2022-03-04 NuCana plc Dijastereoselektivna sinteza derivata fosfata i prolijeka gemcitabina nuc-1031
DK3393478T3 (da) 2015-12-23 2020-03-23 NuCana plc Kombinationsterapi
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
CA3008769A1 (en) 2015-12-23 2017-06-29 NuCana plc Combination therapy comprising nuc-1031 and cisplatin
CN107652342A (zh) 2016-07-23 2018-02-02 江苏万高药业股份有限公司 核苷氨基磷酸酯类前药的多晶型及其制备方法

Also Published As

Publication number Publication date
HK1255112A1 (zh) 2019-08-02
JP2018538341A (ja) 2018-12-27
MX2018007782A (es) 2018-08-15
CN108699099A (zh) 2018-10-23
CA3008556A1 (en) 2017-06-29
WO2017109485A1 (en) 2017-06-29
AU2016375860A1 (en) 2018-07-05
GB201522771D0 (en) 2016-02-03
US20210188893A1 (en) 2021-06-24
JP6840151B2 (ja) 2021-03-10
EP3394077A1 (en) 2018-10-31
SG11201805061YA (en) 2018-07-30
KR20180096685A (ko) 2018-08-29
AU2016375860B2 (en) 2021-06-03
US11377467B2 (en) 2022-07-05
BR112018012943A2 (pt) 2018-12-11

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