MX379110B - Derivados de azaspiro como antagonistas de trpm8. - Google Patents

Derivados de azaspiro como antagonistas de trpm8.

Info

Publication number
MX379110B
MX379110B MX2016011632A MX2016011632A MX379110B MX 379110 B MX379110 B MX 379110B MX 2016011632 A MX2016011632 A MX 2016011632A MX 2016011632 A MX2016011632 A MX 2016011632A MX 379110 B MX379110 B MX 379110B
Authority
MX
Mexico
Prior art keywords
azaspiro derivatives
trpm8 antagonists
azaspiro
derivatives
trpm8
Prior art date
Application number
MX2016011632A
Other languages
English (en)
Other versions
MX2016011632A (es
Inventor
Kazuo Ando
Masashi Ohmi
Yuji Shishido
Original Assignee
Raqualia Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Raqualia Pharma Inc filed Critical Raqualia Pharma Inc
Publication of MX2016011632A publication Critical patent/MX2016011632A/es
Publication of MX379110B publication Critical patent/MX379110B/es

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

La presente invención se refiere a derivados de azaespiro de la fórmula (I) o una sal farmacéuticamente aceptable de éste o un profármaco de éste, a procesos para su preparación, composiciones farmacéuticas que los contienen y a sus usos en el tratamiento de varios desórdenes que son mediados por el receptor TRPM8. (ver Fórmula).
MX2016011632A 2014-03-14 2015-03-16 Derivados de azaspiro como antagonistas de trpm8. MX379110B (es)

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CA2816983A1 (en) 2010-11-05 2012-05-10 Senomyx, Inc. Compounds useful as modulators of trpm8
KR20160113158A (ko) 2014-01-27 2016-09-28 몰레큘러 템플레이츠, 인코퍼레이션. 폴리펩티드를 전달하는 mhc 클래스 i 항원결정기
JP6771492B2 (ja) 2015-05-30 2020-10-21 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 脱免疫化された志賀毒素ａサブユニット足場及びそれを含む細胞標的化分子
CR20180102A (es) 2015-08-14 2018-05-11 Bayer Cropscience Ag Derivados de triazol, sus intermediarios y su utilización como fungicidas
EP3350171A1 (en) * 2015-09-11 2018-07-25 RaQualia Pharma Inc. Imidazolinone derivatives as trpm8 antagonists
US10392371B2 (en) * 2015-10-01 2019-08-27 Senomyx, Inc. Compounds useful as modulators of TRPM8
CN110946865B (zh) 2015-12-10 2024-01-26 Ptc医疗公司 用于治疗亨廷顿病的方法
LT3402782T (lt) * 2016-01-13 2020-10-12 Grünenthal GmbH 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekano dariniai
KR20190005877A (ko) * 2016-05-19 2019-01-16 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Trpv4 길항제
JP7075134B2 (ja) 2016-12-07 2022-05-25 モレキュラー テンプレーツ，インク． 部位特異的コンジュゲーションのための志賀毒素ａサブユニットエフェクターポリペプチド、志賀毒素エフェクター足場、及び細胞標的化分子
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