MX375754B - Preparación de una forma sólida de dimeglumina de gadobenato. - Google Patents
Preparación de una forma sólida de dimeglumina de gadobenato.Info
- Publication number
- MX375754B MX375754B MX2017000955A MX2017000955A MX375754B MX 375754 B MX375754 B MX 375754B MX 2017000955 A MX2017000955 A MX 2017000955A MX 2017000955 A MX2017000955 A MX 2017000955A MX 375754 B MX375754 B MX 375754B
- Authority
- MX
- Mexico
- Prior art keywords
- solid form
- gadobenate dimeglumine
- preparation
- solution
- compound
- Prior art date
Links
- 229940096814 gadobenate dimeglumine Drugs 0.000 title abstract 4
- OCDAWJYGVOLXGZ-VPVMAENOSA-K gadobenate dimeglumine Chemical compound [Gd+3].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC(O)=O)C(C([O-])=O)COCC1=CC=CC=C1 OCDAWJYGVOLXGZ-VPVMAENOSA-K 0.000 title abstract 3
- 239000007787 solid Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000012296 anti-solvent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- -1 gadobenate dimeglumine compound Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Radiology & Medical Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nanotechnology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Abstract
La presente invención se refiere a un proceso para la preparación de una forma sólida del compuesto de dimeglumina de gadobenato que comprende obtener una solución de tal compuesto en un solvente A adecuado en donde la cantidad por peso del agua opcionalmente presente en la solución es como mucho igual a o menor que la cantidad por peso de la dimeglumina de gadobenato comprendida en la solución y agregar la solución obtenida a un solvente orgánico B, que actúa como un antisolvente apropiado y favoreciendo la formación de una forma sólida de la dimeglumina de gadobenato que se puede colectar por filtración.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14178283.9A EP2977369A1 (en) | 2014-07-24 | 2014-07-24 | Preparation of a solid form of gadobenate dimeglumine |
| PCT/EP2015/066512 WO2016012386A1 (en) | 2014-07-24 | 2015-07-20 | Preparation of a solid form of gadobenate dimeglumine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017000955A MX2017000955A (es) | 2017-05-01 |
| MX375754B true MX375754B (es) | 2025-03-06 |
Family
ID=51260603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017000955A MX375754B (es) | 2014-07-24 | 2015-07-20 | Preparación de una forma sólida de dimeglumina de gadobenato. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US10519171B2 (es) |
| EP (2) | EP2977369A1 (es) |
| JP (1) | JP6625605B2 (es) |
| KR (1) | KR102445718B1 (es) |
| CN (2) | CN111233684B (es) |
| AU (1) | AU2015294042B2 (es) |
| BR (1) | BR112016030362A2 (es) |
| CA (1) | CA2950831C (es) |
| CY (1) | CY1122739T1 (es) |
| DK (1) | DK3172186T3 (es) |
| ES (1) | ES2701099T3 (es) |
| HR (1) | HRP20182018T1 (es) |
| IL (1) | IL250248B (es) |
| LT (1) | LT3172186T (es) |
| MX (1) | MX375754B (es) |
| NZ (1) | NZ727066A (es) |
| PL (1) | PL3172186T3 (es) |
| PT (1) | PT3172186T (es) |
| RS (1) | RS58085B1 (es) |
| RU (1) | RU2693625C2 (es) |
| SG (1) | SG11201610655WA (es) |
| SI (1) | SI3172186T1 (es) |
| WO (1) | WO2016012386A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7603690B2 (ja) | 2019-12-20 | 2024-12-20 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | Ｂｏｐｔａカルシウム錯体 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3520066A (en) * | 1966-05-26 | 1970-07-14 | Pillsbury Co | Spray drying method |
| IT1213029B (it) * | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | Chelati di ioni metallici paramagnetici. |
| ITMI981583A1 (it) * | 1998-07-10 | 2000-01-10 | Bracco Spa | Processo per la preparazione dell'acido 4 -carbossi-5,8,11-tris (carbossimetil)-1-fenil-2-oxa-5,8,11-triazatridecan-13-oico |
| EP2327395A1 (en) * | 2009-11-23 | 2011-06-01 | Bracco Imaging S.p.A | Process for the preparation of gadobenate dimeglumine complex in a solid form |
| EP2338874A1 (en) | 2009-12-16 | 2011-06-29 | Bracco Imaging S.p.A | Process for the preparation of chelated compounds |
| CN102408348A (zh) * | 2011-07-26 | 2012-04-11 | 天津市海文普宁科技发展有限公司 | 一种钆贝葡胺的制备新方法 |
-
2014
- 2014-07-24 EP EP14178283.9A patent/EP2977369A1/en not_active Withdrawn
-
2015
- 2015-07-20 CN CN202010122232.XA patent/CN111233684B/zh active Active
- 2015-07-20 US US15/321,176 patent/US10519171B2/en active Active
- 2015-07-20 CN CN201580039408.2A patent/CN106573875B/zh active Active
- 2015-07-20 HR HRP20182018TT patent/HRP20182018T1/hr unknown
- 2015-07-20 ES ES15738381T patent/ES2701099T3/es active Active
- 2015-07-20 LT LTEP15738381.1T patent/LT3172186T/lt unknown
- 2015-07-20 CA CA2950831A patent/CA2950831C/en active Active
- 2015-07-20 WO PCT/EP2015/066512 patent/WO2016012386A1/en not_active Ceased
- 2015-07-20 JP JP2017503862A patent/JP6625605B2/ja active Active
- 2015-07-20 MX MX2017000955A patent/MX375754B/es active IP Right Grant
- 2015-07-20 PL PL15738381T patent/PL3172186T3/pl unknown
- 2015-07-20 SG SG11201610655WA patent/SG11201610655WA/en unknown
- 2015-07-20 NZ NZ727066A patent/NZ727066A/en unknown
- 2015-07-20 SI SI201530506T patent/SI3172186T1/sl unknown
- 2015-07-20 EP EP15738381.1A patent/EP3172186B1/en active Active
- 2015-07-20 BR BR112016030362-8A patent/BR112016030362A2/pt not_active Application Discontinuation
- 2015-07-20 RU RU2017105846A patent/RU2693625C2/ru active
- 2015-07-20 PT PT15738381T patent/PT3172186T/pt unknown
- 2015-07-20 RS RS20181457A patent/RS58085B1/sr unknown
- 2015-07-20 DK DK15738381.1T patent/DK3172186T3/en active
- 2015-07-20 KR KR1020177001272A patent/KR102445718B1/ko active Active
- 2015-07-20 AU AU2015294042A patent/AU2015294042B2/en active Active
-
2017
- 2017-01-23 IL IL25024817A patent/IL250248B/en active IP Right Grant
-
2018
- 2018-12-04 CY CY20181101289T patent/CY1122739T1/el unknown
-
2019
- 2019-11-08 US US16/678,082 patent/US11014942B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |