MX375485B - Derivados biciclicos de piridina, pirazina y pirimidina como inhibidores de pi3k beta - Google Patents

Derivados biciclicos de piridina, pirazina y pirimidina como inhibidores de pi3k beta

Info

Publication number
MX375485B
MX375485B MX2018015707A MX2018015707A MX375485B MX 375485 B MX375485 B MX 375485B MX 2018015707 A MX2018015707 A MX 2018015707A MX 2018015707 A MX2018015707 A MX 2018015707A MX 375485 B MX375485 B MX 375485B
Authority
MX
Mexico
Prior art keywords
pyrazine
pyrimidine derivatives
beta inhibitors
bicyclic pyridine
pi3k beta
Prior art date
Application number
MX2018015707A
Other languages
English (en)
Other versions
MX2018015707A (es
Inventor
Christophe Gabriel Marcel Demestre
Christophe Meyer
Didier Jean- Claude BERTHELOT
Elisabeth Thérèse Jeanne Pasquier
Guillaume Jean Maurice Mercey
Isabelle Noëlle Constance Pilatte
Laurence Anne Mevellec
Lieven Meerpoel
Olivier Alexis Georges Querolle
Patrick René Angibaud
Sophie Coupa
Virginie Sophie Poncelet
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2018015707A publication Critical patent/MX2018015707A/es
Publication of MX375485B publication Critical patent/MX375485B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invencion se refiere a derivados de piridina, pirazina y pirimidina biciclicos de Formula (I) (ver fórmula) en donde las variables tienen el significado definido en las reivindicaciones; los compuestos de acuerdo con la presente invencion son utiles como inhibidores pI3Kß; la invencion se refiere además a composiciones farmaceuticas que comprenden dichos compuestos como principio activo, asi como tambien al uso de dichos compuestos como un medicamento.
MX2018015707A 2016-06-16 2017-06-15 Derivados biciclicos de piridina, pirazina y pirimidina como inhibidores de pi3k beta MX375485B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16174715 2016-06-16
PCT/EP2017/064671 WO2017216292A1 (en) 2016-06-16 2017-06-15 Bicyclic pyridine, pyrazine, and pyrimidine derivatives as pi3k beta inhibitors

Publications (2)

Publication Number Publication Date
MX2018015707A MX2018015707A (es) 2019-03-21
MX375485B true MX375485B (es) 2025-03-06

Family

ID=56132835

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018015707A MX375485B (es) 2016-06-16 2017-06-15 Derivados biciclicos de piridina, pirazina y pirimidina como inhibidores de pi3k beta

Country Status (17)

Country Link
US (1) US10894793B2 (es)
EP (1) EP3472160B1 (es)
JP (1) JP7149854B2 (es)
KR (1) KR102472453B1 (es)
CN (1) CN109311875A (es)
AU (1) AU2017286379B2 (es)
CA (1) CA3025594C (es)
DK (1) DK3472160T3 (es)
EA (1) EA037361B1 (es)
ES (1) ES2871140T3 (es)
HR (1) HRP20210508T1 (es)
HU (1) HUE054118T2 (es)
IL (1) IL263652A (es)
LT (1) LT3472160T (es)
MX (1) MX375485B (es)
SI (1) SI3472160T1 (es)
WO (1) WO2017216292A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI817956B (zh) * 2017-09-08 2023-10-11 英屬開曼群島商百濟神州有限公司 咪唑並[1,5-A]吡嗪衍生物作爲PI3Kδ 抑制劑
CN111039946A (zh) * 2018-10-15 2020-04-21 上海轶诺药业有限公司 一类咪唑并芳环类化合物的制备和应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090170848A1 (en) 2006-03-02 2009-07-02 Smithkline Beecham Corporation Thiazolones for use as pi3 kinase inhibitors
US20090215818A1 (en) 2006-07-24 2009-08-27 Smithkline Beecham Corporation Thiozolidinedione derivatives as pi3 kinase inhibitors
CA2675884C (en) 2007-02-22 2016-04-26 Merck Serono S.A. Quinoxaline compounds and use thereof
WO2009021083A1 (en) 2007-08-09 2009-02-12 Smithkline Beecham Corporation Quinoxaline derivatives as pi3 kinase inhibitors
DK2240451T3 (da) 2008-01-04 2017-11-20 Intellikine Llc Isoquinolinonderivater substitueret med en purin, der er anvendelig som pi3k-inhibitorer
JP5576403B2 (ja) 2009-02-06 2014-08-20 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド γ分泌酵素調節物質としての新規置換二環複素環化合物
KR20110114663A (ko) 2009-02-13 2011-10-19 바이엘 파마 악티엔게젤샤프트 융합된 피리미딘
CA2755285C (en) 2009-03-20 2014-02-11 Yunxin Y. Bo Inhibitors of pi3 kinase
KR101721280B1 (ko) 2009-08-17 2017-03-29 인텔리카인, 엘엘씨 헤테로사이클릭 화합물 및 이의 용도
AU2010300719A1 (en) 2009-09-29 2012-05-03 Xcovery Holding Company Llc PI3K (delta) selective inhibitors
DE102009052575A1 (de) 2009-11-10 2011-05-12 Siemens Medical Instruments Pte. Ltd. Verfahren, Hörgerät und Anordnung zur Kalibrierung eines akustischen Anpasssystems
AR080754A1 (es) * 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
UY33304A (es) 2010-04-02 2011-10-31 Amgen Inc Compuestos heterocíclicos y sus usos
PT2624696T (pt) 2010-10-06 2017-03-21 Glaxosmithkline Llc Derivados de benzimidazole como inibidores da cinase pi3
US9127000B2 (en) 2011-02-23 2015-09-08 Intellikine, LLC. Heterocyclic compounds and uses thereof
WO2013028263A1 (en) 2011-08-24 2013-02-28 Glaxosmithkline Llc Pyrazolopyrimidine derivatives as pi3 kinase inhibitors
US8778937B2 (en) 2011-12-20 2014-07-15 Glaxosmithkline Llc Benzimidazole boronic acid derivatives as PI3 kinase inhibitors
US8906910B2 (en) * 2011-12-20 2014-12-09 Glaxosmithkline Llc Imidazopyridine derivatives as PI3 kinase
GB201212513D0 (en) * 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
US9309243B2 (en) 2012-07-13 2016-04-12 Ucb Biopharma Sprl Imidazopyridine derivatives as modulators of TNF activity
TWI574962B (zh) * 2012-11-14 2017-03-21 加拓科學公司 作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途
KR101982912B1 (ko) 2013-10-16 2019-09-10 상하이 잉리 파마슈티컬 컴퍼니 리미티드 융합된 헤테로사이클릭 화합물, 이의 제조 방법, 약학적 조성물, 및 그 용도
JP6568588B2 (ja) 2014-12-19 2019-08-28 ヤンセン ファーマシューティカ エヌ．ベー． ＰＩ３Ｋβ阻害剤としてのイミダゾピリダジン誘導体
HRP20192162T1 (hr) 2014-12-19 2020-02-21 Janssen Pharmaceutica N.V. Heterociklil vezani derivati imidazopiridazina kao inhibitori pi3kbeta
EA037401B1 (ru) 2015-10-09 2021-03-24 Янссен Фармацевтика Нв Производные хиноксалина и пиридопиразина в качестве ингибиторов pi3k

Also Published As

Publication number Publication date
EP3472160B1 (en) 2021-02-24
US10894793B2 (en) 2021-01-19
KR102472453B1 (ko) 2022-11-29
US20190169199A1 (en) 2019-06-06
EA037361B1 (ru) 2021-03-18
JP2019518032A (ja) 2019-06-27
BR112018075999A2 (pt) 2019-04-02
MX2018015707A (es) 2019-03-21
CA3025594A1 (en) 2017-12-21
AU2017286379B2 (en) 2021-07-01
WO2017216292A1 (en) 2017-12-21
AU2017286379A1 (en) 2018-12-06
EA201990046A1 (ru) 2019-05-31
CA3025594C (en) 2024-06-18
EP3472160A1 (en) 2019-04-24
HRP20210508T1 (hr) 2021-05-28
CN109311875A (zh) 2019-02-05
DK3472160T3 (da) 2021-05-10
IL263652A (en) 2019-01-31
KR20190016954A (ko) 2019-02-19
HUE054118T2 (hu) 2021-08-30
JP7149854B2 (ja) 2022-10-07
SI3472160T1 (sl) 2021-07-30
LT3472160T (lt) 2021-04-26
ES2871140T3 (es) 2021-10-28

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