MX375485B - Derivados biciclicos de piridina, pirazina y pirimidina como inhibidores de pi3k beta - Google Patents

Derivados biciclicos de piridina, pirazina y pirimidina como inhibidores de pi3k beta

Info

Publication number
MX375485B
MX375485B MX2018015707A MX2018015707A MX375485B MX 375485 B MX375485 B MX 375485B MX 2018015707 A MX2018015707 A MX 2018015707A MX 2018015707 A MX2018015707 A MX 2018015707A MX 375485 B MX375485 B MX 375485B
Authority
MX
Mexico
Prior art keywords
pyrazine
pyrimidine derivatives
beta inhibitors
bicyclic pyridine
pi3k beta
Prior art date
Application number
MX2018015707A
Other languages
English (en)
Other versions
MX2018015707A (es
Inventor
Christophe Gabriel Marcel Demestre
Christophe Meyer
Didier Jean- Claude BERTHELOT
Elisabeth Thérèse Jeanne Pasquier
Guillaume Jean Maurice Mercey
Isabelle Noëlle Constance Pilatte
Laurence Anne Mevellec
Lieven Meerpoel
Olivier Alexis Georges Querolle
Patrick René Angibaud
Sophie Coupa
Virginie Sophie Poncelet
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2018015707A publication Critical patent/MX2018015707A/es
Publication of MX375485B publication Critical patent/MX375485B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invencion se refiere a derivados de piridina, pirazina y pirimidina biciclicos de Formula (I) (ver fórmula) en donde las variables tienen el significado definido en las reivindicaciones; los compuestos de acuerdo con la presente invencion son utiles como inhibidores pI3Kß; la invencion se refiere además a composiciones farmaceuticas que comprenden dichos compuestos como principio activo, asi como tambien al uso de dichos compuestos como un medicamento.
MX2018015707A 2016-06-16 2017-06-15 Derivados biciclicos de piridina, pirazina y pirimidina como inhibidores de pi3k beta MX375485B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16174715 2016-06-16
PCT/EP2017/064671 WO2017216292A1 (en) 2016-06-16 2017-06-15 Bicyclic pyridine, pyrazine, and pyrimidine derivatives as pi3k beta inhibitors

Publications (2)

Publication Number Publication Date
MX2018015707A MX2018015707A (es) 2019-03-21
MX375485B true MX375485B (es) 2025-03-06

Family

ID=56132835

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018015707A MX375485B (es) 2016-06-16 2017-06-15 Derivados biciclicos de piridina, pirazina y pirimidina como inhibidores de pi3k beta

Country Status (17)

Country Link
US (1) US10894793B2 (es)
EP (1) EP3472160B1 (es)
JP (1) JP7149854B2 (es)
KR (1) KR102472453B1 (es)
CN (1) CN109311875A (es)
AU (1) AU2017286379B2 (es)
CA (1) CA3025594C (es)
DK (1) DK3472160T3 (es)
EA (1) EA037361B1 (es)
ES (1) ES2871140T3 (es)
HR (1) HRP20210508T1 (es)
HU (1) HUE054118T2 (es)
IL (1) IL263652A (es)
LT (1) LT3472160T (es)
MX (1) MX375485B (es)
SI (1) SI3472160T1 (es)
WO (1) WO2017216292A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ761680A (en) * 2017-09-08 2023-03-31 Beigene Ltd Imidazo[1,5-a]pyrazine derivatives as pi3kdelta inhibitors
CN111039946A (zh) * 2018-10-15 2020-04-21 上海轶诺药业有限公司 一类咪唑并芳环类化合物的制备和应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090170848A1 (en) 2006-03-02 2009-07-02 Smithkline Beecham Corporation Thiazolones for use as pi3 kinase inhibitors
EP2046333A4 (en) 2006-07-24 2010-09-15 Glaxosmithkline Llc THIOZOLIDINEDIONE DERIVATIVES AS INHIBITORS OF P13-KINASE
ZA200904857B (en) 2007-02-22 2010-09-29 Merck Serono Sa Quinoxaline compounds and use thereof
JP2010535804A (ja) 2007-08-09 2010-11-25 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｐｉ３キナーゼ阻害薬としてのキノキサリン誘導体
BRPI0906473A8 (pt) 2008-01-04 2016-02-10 Intellikine Inc Certas entidades químicas, composições e métodos
CN102325765B (zh) 2009-02-06 2014-12-24 杨森制药公司 作为γ-分泌酶调节剂的取代的双环杂环化合物
US8957064B2 (en) 2009-02-13 2015-02-17 Bayer Intellectual Property Gmbh Fused pyrimidines
CA2755285C (en) 2009-03-20 2014-02-11 Yunxin Y. Bo Inhibitors of pi3 kinase
UA111579C2 (uk) 2009-08-17 2016-05-25 Інтеллікіне Ллк ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ
US8569296B2 (en) 2009-09-29 2013-10-29 Xcovery Holding Company, Llc PI3K (delta) selective inhibitors
DE102009052575A1 (de) 2009-11-10 2011-05-12 Siemens Medical Instruments Pte. Ltd. Verfahren, Hörgerät und Anordnung zur Kalibrierung eines akustischen Anpasssystems
AR080754A1 (es) * 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
UY33304A (es) 2010-04-02 2011-10-31 Amgen Inc Compuestos heterocíclicos y sus usos
KR101594002B1 (ko) 2010-10-06 2016-02-15 글락소스미스클라인 엘엘씨 Ｐｉ３ 키나제 억제제로서의 벤즈이미다졸 유도체
WO2012116237A2 (en) 2011-02-23 2012-08-30 Intellikine, Llc Heterocyclic compounds and uses thereof
WO2013028263A1 (en) 2011-08-24 2013-02-28 Glaxosmithkline Llc Pyrazolopyrimidine derivatives as pi3 kinase inhibitors
US8778937B2 (en) 2011-12-20 2014-07-15 Glaxosmithkline Llc Benzimidazole boronic acid derivatives as PI3 kinase inhibitors
US8906910B2 (en) * 2011-12-20 2014-12-09 Glaxosmithkline Llc Imidazopyridine derivatives as PI3 kinase
ES2689429T3 (es) 2012-07-13 2018-11-14 Ucb Biopharma Sprl Derivados de imidazopiridina como moduladores de actividad de TNF
GB201212513D0 (en) 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
TWI574962B (zh) * 2012-11-14 2017-03-21 加拓科學公司 作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途
CN106831722B (zh) 2013-10-16 2019-08-30 上海璎黎药业有限公司 稠合杂环化合物、其制备方法、药物组合物和用途
DK3233862T3 (da) 2014-12-19 2019-10-07 Janssen Pharmaceutica Nv Imidazopyridazinderivater som pi3k-beta-inhibitorer
JP6586463B2 (ja) 2014-12-19 2019-10-02 ヤンセン ファーマシューティカ エヌ．ベー． ＰＩ３Ｋβ阻害剤としての複素環連結イミダゾピリダジン誘導体
BR112018007068B1 (pt) 2015-10-09 2024-01-02 Janssen Pharmaceutica N.V. Derivados de quinoxalina e piridopirazina como inibidores de pi3kbeta, seu uso e composição farmacêutica que os compreende

Also Published As

Publication number Publication date
KR20190016954A (ko) 2019-02-19
US10894793B2 (en) 2021-01-19
ES2871140T3 (es) 2021-10-28
AU2017286379B2 (en) 2021-07-01
MX2018015707A (es) 2019-03-21
HRP20210508T1 (hr) 2021-05-28
LT3472160T (lt) 2021-04-26
EP3472160B1 (en) 2021-02-24
IL263652A (en) 2019-01-31
DK3472160T3 (da) 2021-05-10
WO2017216292A1 (en) 2017-12-21
SI3472160T1 (sl) 2021-07-30
CN109311875A (zh) 2019-02-05
JP2019518032A (ja) 2019-06-27
CA3025594A1 (en) 2017-12-21
US20190169199A1 (en) 2019-06-06
CA3025594C (en) 2024-06-18
KR102472453B1 (ko) 2022-11-29
EP3472160A1 (en) 2019-04-24
JP7149854B2 (ja) 2022-10-07
EA037361B1 (ru) 2021-03-18
BR112018075999A2 (pt) 2019-04-02
AU2017286379A1 (en) 2018-12-06
HUE054118T2 (hu) 2021-08-30
EA201990046A1 (ru) 2019-05-31

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