MX374637B - Moduladores de ror gamma (ror?). - Google Patents

Moduladores de ror gamma (ror?).

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Publication number
MX374637B
MX374637B MX2017015743A MX2017015743A MX374637B MX 374637 B MX374637 B MX 374637B MX 2017015743 A MX2017015743 A MX 2017015743A MX 2017015743 A MX2017015743 A MX 2017015743A MX 374637 B MX374637 B MX 374637B
Authority
MX
Mexico
Prior art keywords
sub
ror
modulators
gamma
ror gamma
Prior art date
Application number
MX2017015743A
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English (en)
Other versions
MX2017015743A (es
Inventor
David Machnik
Jean- Francois SABUCO
Joseph Maria Gerardus Barbara Cals
Laurent Schio
Sander Bernardus Nabuurs
Original Assignee
Lead Pharma Holding Bv
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lead Pharma Holding Bv, Sanofi Sa filed Critical Lead Pharma Holding Bv
Publication of MX2017015743A publication Critical patent/MX2017015743A/es
Publication of MX374637B publication Critical patent/MX374637B/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
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Abstract

La presente invención se refiere a novedosos compuestos de acuerdo con la Fórmula I (ver Fórmula) Meta o para - o una de sus sales aceptables desde el punto de vista farmacéutico caracterizado porque: A11 - A14 son N o CR11, CR12, CR13, CR14, respectivamente, con la salvedad de que no más de dos de las cuatro posiciones A en A11-A14 puedan ser simultáneamente N; - A6, A7, A8, A9,A10 son N o CR6, CR7, CR8, CR9, CR10, respectivamente, con la salvedad de que al menos una pero no más de dos de las cinco posiciones A en A6, A7, A8, A9, A10 es N; - R1 es C(2-6)alquilo, C(3-6)cicloalquilo, C(3-6)cicloalquilC(1-3)alquilo, (di)C(3-6)cicloalquilamino o (di)(C(3-6)cicloalquilC(1-3)alquil)amino; - R5 es H, hidroxietilo, metoxietilo, C(1-6)alquilo, C(6-10)arilo, C(6-10)arilC(1-3)alquilo, C(1-9) heteroarilo, C(1-9)heteroarilC(1-3)alquilo, C(3-6)cicloalquilo, C(3-6)cicloalquil-C(1-3)alquilo, C(2-5)heterocicloalquilo o C(2-5)heterocicloalquilC(1-3)alquilo; - el grupo sulfonilo con R1 está representado por uno de R7, R8 o R9; - R15 es H, C(1-6)alquilo, C(3-6)cicloalquilo, C(3-6)cicloalquilC(1-3)alquilo, C(6-10)arilo, C(6-10)arilC(1-3)alquilo, C(1-9)heteroarilo, C(1-9)heteroarilC(1-3)alquilo, C(2-5)heterocicloalquilo o C(2-5) heterocicloalquil-C(1-3)alquilo; - y R16 es C(1-6)alquilo, C(3-6)cicloalquilo, C(3-6)cicloalquilC(1-3)alquilo, C(6-10)arilo, C(6-10)arilC(1-3)alquilo, C(1-9)heteroarilo, C(1-9)heteroarilC(1-3)alquilo, C(2-5)heterocicloalquilo o C(2-5) heterocicloalquil-C(1-3)alquilo.
MX2017015743A 2015-06-05 2016-06-03 Moduladores de ror gamma (ror?). MX374637B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15170768.4A EP3101005A1 (en) 2015-06-05 2015-06-05 Ror gamma (rory) modulators
PCT/EP2016/062708 WO2016193468A1 (en) 2015-06-05 2016-06-03 Ror gamma (rory) modulators

Publications (2)

Publication Number Publication Date
MX2017015743A MX2017015743A (es) 2018-04-24
MX374637B true MX374637B (es) 2025-03-06

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US (2) US10118895B2 (es)
EP (2) EP3101005A1 (es)
JP (1) JP6824198B2 (es)
KR (1) KR102591910B1 (es)
CN (1) CN107922337B (es)
AR (1) AR104881A1 (es)
AU (1) AU2016273360B2 (es)
BR (1) BR112017026229B1 (es)
CA (1) CA2988009C (es)
ES (1) ES2789449T3 (es)
IL (1) IL256039B (es)
MX (1) MX374637B (es)
PL (1) PL3319942T3 (es)
PT (1) PT3319942T (es)
RU (1) RU2733406C2 (es)
WO (1) WO2016193468A1 (es)

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EP3101005A1 (en) * 2015-06-05 2016-12-07 Lead Pharma Cel Models IP B.V. Ror gamma (rory) modulators
EP3101009A1 (en) 2015-06-05 2016-12-07 Lead Pharma Cel Models IP B.V. Ror gamma (rory) modulators
TWI728017B (zh) 2015-12-15 2021-05-21 瑞典商阿斯特捷利康公司 異吲哚化合物、包含其之醫藥組成物及其用途
US20190152962A1 (en) 2016-07-14 2019-05-23 Cadila Healthcare Limited Cyclopropyl derivatives as ror-gamma modulators
TW201815388A (zh) 2016-07-14 2018-05-01 印度商卡迪拉保健有限公司 作為ＲＯＲγ調節劑之新穎化合物
UY37507A (es) 2016-12-05 2018-06-29 Lead Pharma Holding Bv Moduladores de ror gamma (ror¿)
CN110730780A (zh) 2017-06-14 2020-01-24 阿斯利康(瑞典)有限公司 用作ROR-γ调节剂的2，3-二氢异吲哚-1-甲酰胺
TW202136238A (zh) * 2020-01-06 2021-10-01 大陸商廣東東陽光藥業有限公司 RORγt抑制劑及其製備方法和用途

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