MX371087B - Vacunas sintéticas contra el serotipo 2 de streptococcus pneumoniae. - Google Patents
Vacunas sintéticas contra el serotipo 2 de streptococcus pneumoniae.Info
- Publication number
- MX371087B MX371087B MX2018007367A MX2018007367A MX371087B MX 371087 B MX371087 B MX 371087B MX 2018007367 A MX2018007367 A MX 2018007367A MX 2018007367 A MX2018007367 A MX 2018007367A MX 371087 B MX371087 B MX 371087B
- Authority
- MX
- Mexico
- Prior art keywords
- against streptococcus
- streptococcus pneumoniae
- vaccines against
- pneumoniae serotype
- synthetic vaccines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
Abstract
La presente invención se refiere a un sacárido sintético de fórmula general (I) que está relacionado con el polisacárido capsular del serotipo 2 de Streptococcus pneumoniae, un conjugado del mismo y el uso de dicho sacárido y conjugado para generar una respuesta inmune protectora en un huésped humano y/o animal. Además, el sacárido sintético de fórmula general (I) es útil como marcador en ensayos inmunológicos para la detección de anticuerpos contra la bacteria Streptococcus pneumoniae tipo 2.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15200729.0A EP3181148A1 (en) | 2015-12-17 | 2015-12-17 | Synthetic vaccines against streptococcus pneumoniae serotype 2 |
EP16167505 | 2016-04-28 | ||
PCT/EP2016/081586 WO2017103211A1 (en) | 2015-12-17 | 2016-12-16 | Synthetic vaccines against streptococcus pneumoniae serotype 2 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2018007367A MX2018007367A (es) | 2018-08-14 |
MX371087B true MX371087B (es) | 2020-01-16 |
Family
ID=57543058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018007367A MX371087B (es) | 2015-12-17 | 2016-12-16 | Vacunas sintéticas contra el serotipo 2 de streptococcus pneumoniae. |
Country Status (13)
Country | Link |
---|---|
US (1) | US10864261B2 (es) |
EP (1) | EP3331556B8 (es) |
JP (1) | JP6630440B2 (es) |
KR (1) | KR20180091921A (es) |
CN (1) | CN108367059B (es) |
AU (1) | AU2016372547A1 (es) |
BR (1) | BR112018012310A2 (es) |
HK (1) | HK1256630B (es) |
IL (1) | IL259289B (es) |
MX (1) | MX371087B (es) |
PH (1) | PH12018501205A1 (es) |
SG (1) | SG11201803881RA (es) |
WO (1) | WO2017103211A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10188718B2 (en) * | 2014-12-12 | 2019-01-29 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Vaccines against Streptococcus pneumoniae serotype 4 |
AU2016372547A1 (en) | 2015-12-17 | 2018-07-05 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Synthetic vaccines against streptococcus pneumoniae serotype 2 |
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
EP4247828A1 (en) * | 2020-11-20 | 2023-09-27 | Institut Pasteur | Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0607088D0 (en) * | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
RU2536248C2 (ru) * | 2009-04-30 | 2014-12-20 | Коули Фармасьютикал Груп, Инк. | Пневмококковая вакцина и ее применения |
KR20140075196A (ko) * | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
PL3363806T3 (pl) | 2012-12-20 | 2022-12-19 | Pfizer Inc. | Sposób glikokoniugacji |
CA2961694C (en) * | 2014-09-26 | 2022-11-01 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Vaccines against streptococcus pneumoniae serotype 8 |
US10188718B2 (en) * | 2014-12-12 | 2019-01-29 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Vaccines against Streptococcus pneumoniae serotype 4 |
AU2016372547A1 (en) | 2015-12-17 | 2018-07-05 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Synthetic vaccines against streptococcus pneumoniae serotype 2 |
EP3474890A1 (en) * | 2016-06-22 | 2019-05-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften E. V. | Pneumococcal polysaccharide-protein conjugate composition |
-
2016
- 2016-12-16 AU AU2016372547A patent/AU2016372547A1/en not_active Abandoned
- 2016-12-16 WO PCT/EP2016/081586 patent/WO2017103211A1/en active Application Filing
- 2016-12-16 JP JP2018531531A patent/JP6630440B2/ja active Active
- 2016-12-16 KR KR1020187020397A patent/KR20180091921A/ko not_active Application Discontinuation
- 2016-12-16 SG SG11201803881RA patent/SG11201803881RA/en unknown
- 2016-12-16 MX MX2018007367A patent/MX371087B/es active IP Right Grant
- 2016-12-16 EP EP16809888.7A patent/EP3331556B8/en active Active
- 2016-12-16 CN CN201680073724.6A patent/CN108367059B/zh active Active
- 2016-12-16 US US16/061,478 patent/US10864261B2/en active Active
- 2016-12-16 BR BR112018012310A patent/BR112018012310A2/pt not_active Application Discontinuation
-
2018
- 2018-05-10 IL IL259289A patent/IL259289B/en active IP Right Grant
- 2018-06-07 PH PH12018501205A patent/PH12018501205A1/en unknown
- 2018-12-10 HK HK18115764.2A patent/HK1256630B/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN108367059A (zh) | 2018-08-03 |
SG11201803881RA (en) | 2018-06-28 |
WO2017103211A1 (en) | 2017-06-22 |
JP6630440B2 (ja) | 2020-01-15 |
KR20180091921A (ko) | 2018-08-16 |
EP3331556B8 (en) | 2019-02-27 |
EP3331556B1 (en) | 2018-10-31 |
EP3331556A1 (en) | 2018-06-13 |
IL259289B (en) | 2019-12-31 |
US10864261B2 (en) | 2020-12-15 |
CN108367059B (zh) | 2022-10-11 |
IL259289A (en) | 2018-07-31 |
MX2018007367A (es) | 2018-08-14 |
HK1256630B (zh) | 2020-05-22 |
US20200016257A1 (en) | 2020-01-16 |
JP2019504017A (ja) | 2019-02-14 |
BR112018012310A2 (pt) | 2018-12-04 |
AU2016372547A1 (en) | 2018-07-05 |
PH12018501205A1 (en) | 2019-02-11 |
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