MX370976B - Acc inhibitors and uses thereof. - Google Patents

Acc inhibitors and uses thereof.

Info

Publication number
MX370976B
MX370976B MX2016016733A MX2016016733A MX370976B MX 370976 B MX370976 B MX 370976B MX 2016016733 A MX2016016733 A MX 2016016733A MX 2016016733 A MX2016016733 A MX 2016016733A MX 370976 B MX370976 B MX 370976B
Authority
MX
Mexico
Prior art keywords
acc
plant
inhibitors
acc inhibitors
hyperiipidemia
Prior art date
Application number
MX2016016733A
Other languages
Spanish (es)
Inventor
E Masse Craig
Harwood James
Bhat Sathesh
C Harriman Geraldine
robert greenwood Jeremy
Original Assignee
Gilead Apollo Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Apollo Llc filed Critical Gilead Apollo Llc
Publication of MX370976B publication Critical patent/MX370976B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides compounds, specifically thienopyrimidine derivatives, useful as inhibitors of Acetyl CoA Carboxylase (ACC), pharmaceutical compositions thereof, and methods of using the same for treating ACC-mediated disorders such as obesity, dyslipidemia, hyperiipidemia, fungal, parasitic or bacterial infections in a subject. The invention further provides a method of inhibiting ACC in a plant comprising contacting the plant with the inhibitor compound.
MX2016016733A 2011-11-11 2012-11-09 Acc inhibitors and uses thereof. MX370976B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161559023P 2011-11-11 2011-11-11
US201261615092P 2012-03-23 2012-03-23
US201261651878P 2012-05-25 2012-05-25
US201261675513P 2012-07-25 2012-07-25
PCT/US2012/064528 WO2013071169A1 (en) 2011-11-11 2012-11-09 Acc inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
MX370976B true MX370976B (en) 2020-01-10

Family

ID=48281206

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2020000331A MX2020000331A (en) 2011-11-11 2012-11-09 Acc inhibitors and uses thereof.
MX2014005693A MX344490B (en) 2011-11-11 2012-11-09 Acc inhibitors and uses thereof.
MX2016016733A MX370976B (en) 2011-11-11 2012-11-09 Acc inhibitors and uses thereof.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2020000331A MX2020000331A (en) 2011-11-11 2012-11-09 Acc inhibitors and uses thereof.
MX2014005693A MX344490B (en) 2011-11-11 2012-11-09 Acc inhibitors and uses thereof.

Country Status (26)

Country Link
US (5) US8969557B2 (en)
EP (3) EP2776038B1 (en)
JP (4) JP6114297B2 (en)
KR (3) KR102172902B1 (en)
CN (3) CN106905346B (en)
AU (3) AU2012335088B2 (en)
BR (2) BR122019026836B1 (en)
CA (1) CA2855372C (en)
CL (1) CL2014001241A1 (en)
CY (2) CY1120224T1 (en)
DK (2) DK2776038T3 (en)
EA (2) EA033598B1 (en)
ES (3) ES2912574T3 (en)
HK (1) HK1201207A1 (en)
HR (2) HRP20180534T1 (en)
HU (2) HUE037444T2 (en)
LT (2) LT3329919T (en)
MX (3) MX2020000331A (en)
PL (3) PL3628320T3 (en)
PT (2) PT3329919T (en)
RS (1) RS57157B1 (en)
SI (2) SI3329919T1 (en)
TW (4) TWI655193B (en)
UA (2) UA114901C2 (en)
WO (1) WO2013071169A1 (en)
ZA (3) ZA201403633B (en)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI598347B (en) 2009-07-13 2017-09-11 基利科學股份有限公司 Apoptosis signal-regulating kinase inhibitors
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
PL3628320T3 (en) 2011-11-11 2022-07-25 Gilead Apollo, Llc Acc inhibitors and uses thereof
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
EA027929B1 (en) 2012-05-25 2017-09-29 Янссен Сайенсиз Айрлэнд Юси Uracyl spirooxetane nucleosides
ES2750523T3 (en) 2012-12-18 2020-03-26 Almirall Sa Cyclohexyl and quinuclidinyl carbamate derivatives having beta2-adrenergic agonist and M3 muscarinic antagonist activities
TWI643853B (en) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH β2 ADRENERGIC RECEPTOR AGONIST AND M3 MUSCARINIC RECEPTOR ANTAGONIST ACTIVITIES
JP6417401B2 (en) * 2013-05-10 2018-11-07 ギリアド アポロ， エルエルシー ACC inhibitors and uses thereof
EP2994139B1 (en) 2013-05-10 2019-04-10 Gilead Apollo, LLC Acc inhibitors and uses thereof
CA2911818A1 (en) * 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
WO2014182951A1 (en) 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
WO2015003881A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2015003879A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicylic derivatives
WO2015007451A1 (en) 2013-07-15 2015-01-22 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2015007453A1 (en) * 2013-07-15 2015-01-22 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2015010832A1 (en) * 2013-07-22 2015-01-29 Syngenta Participations Ag Microbiocidal heterocyclic derivatives
TW201517906A (en) 2013-07-25 2015-05-16 Almirall Sa Combinations comprising MABA compounds and corticosteroids
TWI641373B (en) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITIES
CN105530940A (en) 2013-09-12 2016-04-27 辉瑞大药厂 Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris
CN105793267B (en) 2013-10-07 2018-02-06 拜耳制药股份公司 Ring-type thieno uracil benzamide type and application thereof
EP3670496A3 (en) 2013-10-17 2020-09-30 Shionogi&Co., Ltd. Acc2 inhibitors
BR112016008799B1 (en) * 2013-10-30 2023-02-23 Shanghai Hengrui Pharmaceutical Co., Ltd. PYRAZOLOPYRIMIDONE OR PYROLOTRIAZONE DERIVATIVES, THEIR INTERMEDIATES, THEIR USES, THEIR PREPARATION PROCESSES, AND THE PHARMACEUTICAL COMPOSITION
MX368072B (en) 2013-12-19 2019-09-18 Novartis Ag [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis.
WO2016023832A1 (en) * 2014-08-11 2016-02-18 Hydra Biosciences, Inc. Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders
TW201617343A (en) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 New bicyclic derivatives having [beta]2 adrenergic agonist and M3 muscarinic antagonist activities
CN105779463B (en) * 2014-12-25 2019-08-09 深圳华大生命科学研究院 VPS13B gene mutation body and its application
EP3597271A1 (en) * 2015-01-09 2020-01-22 Gilead Apollo, LLC Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease
UY36586A (en) 2015-03-26 2016-10-31 Bayer Pharma AG HETEROCICLILMETILTIENOURACILOS AND USE OF THE SAME
WO2016196895A1 (en) * 2015-06-05 2016-12-08 Joslin Diabetes Center, Inc. Methods amd compositions for promoting thermogenic potential
CN105009933B (en) * 2015-06-10 2018-08-14 邓娟 A kind of technique of the cultivating straw mushroom in a manner of ventilating distiller's yeast
CA2971640C (en) 2015-07-06 2020-09-22 Gilead Sciences, Inc. Cot modulators and methods of use thereof
AR106472A1 (en) 2015-10-26 2018-01-17 Gilead Apollo Llc ACC INHIBITORS AND USES OF THE SAME
CA3004798C (en) * 2015-11-25 2023-10-31 Gilead Apollo, Llc Ester acc inhibitors and uses thereof
EP3379933B1 (en) * 2015-11-25 2023-02-15 Gilead Apollo, LLC Fungicidal compositions containing derivatives of 2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine
CA3004796C (en) * 2015-11-25 2023-11-14 Gilead Apollo, Llc Pyrazole acc inhibitors and uses thereof
SI3380479T1 (en) * 2015-11-25 2023-04-28 Gilead Apollo, Llc Triazole acc inhibitors and uses thereof
EP3386591B1 (en) 2015-12-09 2020-06-24 Cadent Therapeutics, Inc. Heteroaromatic nmda receptor modulators and uses thereof
EP4219507A3 (en) 2015-12-09 2023-08-16 Novartis AG Thienopyrimidinone nmda receptor modulators and uses thereof
WO2017147161A1 (en) * 2016-02-23 2017-08-31 Raju Mohan Treatment of dermatological disorders or conditions
EP4364795A3 (en) * 2016-03-02 2024-08-14 Gilead Apollo, LLC Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
CN107286174B (en) * 2016-04-11 2020-08-18 上海勋和医药科技有限公司 Substituted 2,4- (1H,3H) pyrimidinedione as PARP inhibitor and application thereof
CN107629071B (en) * 2016-07-19 2019-12-27 上海勋和医药科技有限公司 Substituted 2,4- (1H,3H) pyrimidinedione as PARP inhibitor and application thereof
WO2018041771A1 (en) 2016-09-02 2018-03-08 Bayer Pharma Aktiengesellschaft (1-methylcyclopropyl)methyl-substituted thienouraciles and use thereof
RU2019111357A (en) 2016-09-23 2020-10-23 Байер Акциенгезельшафт N3-CYCLICALLY SUBSTITUTED THYENOURACILS AND THEIR APPLICATION
US11274107B2 (en) 2016-12-22 2022-03-15 Cadent Therapeutics, Inc. NMDA receptor modulators and uses thereof
AU2018209006B2 (en) * 2017-01-22 2021-04-22 Sunshine Lake Pharma Co., Ltd. Thienopyrimidine derivative and use thereof in medicine
CA3053956C (en) * 2017-03-03 2024-04-23 Gilead Sciences, Inc. Processes for preparing acc inhibitors and solid forms thereof
JP2020509038A (en) * 2017-03-03 2020-03-26 ギリアド アポロ， エルエルシー Methods for preparing fungicidal compounds
WO2018171698A1 (en) * 2017-03-24 2018-09-27 浙江海正药业股份有限公司 Heteroaryl pyrimidone derivative, and preparation method therefor and uses thereof
CN110431144B (en) * 2017-03-24 2022-08-05 浙江海正药业股份有限公司 Cyano-substituted heteroaryl pyrimidone derivatives, and preparation method and application thereof
US20180280394A1 (en) 2017-03-28 2018-10-04 Gilead Sciences, Inc. Methods of treating liver disease
EP3600310A1 (en) 2017-03-28 2020-02-05 Gilead Sciences, Inc. Methods of treating liver disease
AU2018244928B2 (en) 2017-03-31 2023-10-19 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat cervical cancer
KR20190132515A (en) 2017-04-12 2019-11-27 길리애드 사이언시즈, 인코포레이티드 How to treat liver disease
CN107151251A (en) * 2017-05-10 2017-09-12 江苏开元药业有限公司 A kind of preparation method of ACC inhibitor medicaments key intermediate
WO2018231851A1 (en) 2017-06-13 2018-12-20 Gilead Sciences, Inc. Methods of treating liver fibrosis
CN110709402B (en) * 2017-06-15 2022-05-10 浙江海正药业股份有限公司 Heteroaryl pyrimidone derivatives, preparation method and medical application thereof
CN111201234A (en) * 2017-07-17 2020-05-26 南京瑞捷医药科技有限公司 Novel compounds and their use as ACC inhibitors
TW201910338A (en) * 2017-07-26 2019-03-16 大陸商南京聖和藥業股份有限公司 Compounds as ACC inhibitors and their applications
EP3660017A4 (en) * 2017-07-28 2020-12-30 Jiangsu Hengrui Medicine Co., Ltd. Method for preparing pyrimidone heteroaryl derivative and intermediate of pyrimidone heteroaryl derivative
WO2019031384A1 (en) * 2017-08-07 2019-02-14 日本曹達株式会社 1,3,5,6-tetrasubstituted thieno[2,3-d]pyrimidine-2,4-(1h,3h)dione compound and agricultural or horticultural bactericide
KR20190036705A (en) 2017-09-28 2019-04-05 한미약품 주식회사 Novel process for preparing (2r)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethan-1-ol compound and intermediates used therein
CA3077273A1 (en) 2017-10-06 2019-04-11 Gilead Sciences, Inc. Combination therapy comprising an acc inhibitor
WO2019072478A1 (en) 2017-10-10 2019-04-18 Galderma Research & Development Specific acetyl-coa carboxylase inhibitors for use in the treatment and/or prevention of acne
US20200340060A1 (en) 2017-11-13 2020-10-29 Gilead Sciences, Inc. Compositions and methods for identifying and treating liver diseases and monitoring treatment outcomes
CN108129251A (en) * 2017-12-22 2018-06-08 上海应用技术大学 A kind of synthesis technology of 2- ethyl styrenes
EP3805230B1 (en) * 2018-06-05 2024-08-07 Medshine Discovery Inc. Thieno[2,3-c]pyridazin-4(1h)-one derivative and application thereof
EA202190431A1 (en) 2018-08-03 2021-06-11 Кэйдент Терапьютикс, Инк. HETEROAROMATIC NMDA RECEPTOR MODULATORS AND THEIR APPLICATION
CN110950884B (en) * 2018-09-27 2024-03-26 上海翰森生物医药科技有限公司 Di-ring derivative-containing inhibitor, preparation method and application thereof
EP3904357A4 (en) * 2018-11-20 2022-08-03 The National Institutes of Pharmaceutical R&D Co., Ltd Spiro compound and medical uses thereof
US11389432B2 (en) 2018-12-19 2022-07-19 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
BR112021010461A2 (en) 2018-12-19 2021-08-24 Corcept Therapeutics Incorporated Formulation and unit dose for oral administration of relacorillant
EP3669652A1 (en) 2018-12-21 2020-06-24 Bayer AG Active compound combination
CA3124702A1 (en) 2019-01-15 2020-07-23 Gilead Sciences, Inc. Fxr (nr1h4) modulating compounds
CN111484504B (en) * 2019-01-25 2024-05-10 南京圣和药业股份有限公司 Optical isomer of ACC inhibitor and application thereof
WO2020172501A1 (en) 2019-02-22 2020-08-27 Corcept Therapeutics Incorporated Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator
KR20240135055A (en) 2019-03-11 2024-09-10 길리애드 사이언시즈, 인코포레이티드 Formulations of a compound and uses thereof
CN111747916A (en) * 2019-03-27 2020-10-09 尚科生物医药（上海）有限公司 Preparation method of (R) -2- (2-methoxyphenyl) -2- (tetrahydropyran-4-oxy) ethan-1-ol
CN109810085B (en) * 2019-04-19 2019-07-19 上海皓元生物医药科技有限公司 The preparation method of ACC inhibitor and its intermediate
CN111850061B (en) * 2019-04-30 2022-12-09 浙江工业大学 Preparation method of valienamine A ester
CN110343650B (en) * 2019-05-28 2020-12-29 浙江工业大学 Recombinant streptomyces tuberculatus for producing amphotericin B and application thereof
TW202235416A (en) 2019-06-14 2022-09-16 美商基利科學股份有限公司 Cot modulators and methods of use thereof
WO2020255946A1 (en) * 2019-06-17 2020-12-24 日本曹達株式会社 2,4-dioxo-1,4-dihydrothienopyrimidine compound, agricultural and horticultural bactericide
EP3995498A4 (en) 2019-07-02 2023-03-01 Sunshine Lake Pharma Co., Ltd. Thienopyrimidine derivatives having stereo configurations and use thereof in medicine
AR119594A1 (en) * 2019-08-09 2021-12-29 Gilead Sciences Inc THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF
US20220347190A1 (en) 2019-09-19 2022-11-03 Novartis Ag Treatment comprising fxr agonists
CN112574253B (en) * 2019-09-29 2021-08-27 上海喀露蓝科技有限公司 Phosphoric acid or phosphate ester derivative, preparation method and medical application thereof
CN110746439B (en) * 2019-10-18 2020-10-30 南京瑞捷医药科技有限公司 Preparation method of thienopyrimidinedione compound
CA3157658A1 (en) 2019-10-28 2021-05-06 Nippon Soda Co., Ltd. 2,6-dioxo-3,6-dihydropyrimidine compound, agricultural and horticultural bactericide, nematicide, and medical and veterinary antifungal agent
CN112778325A (en) * 2019-11-07 2021-05-11 南京瑞捷医药科技有限公司 ACC inhibitor and application thereof
US11548871B2 (en) 2019-11-15 2023-01-10 Gilead Sciences, Inc. Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof
WO2021112213A1 (en) * 2019-12-05 2021-06-10 日本曹達株式会社 2,4-dioxo-1,4-dihydrothienopyrimidine compound, agricultural or horticultural fungicidal agent, or medical/animal antifungal agent, containing this
CN114746426B (en) 2019-12-05 2023-12-01 漳州片仔癀药业股份有限公司 Crystal forms as ACC1 and ACC2 inhibitors, and preparation method and application thereof
WO2021110138A1 (en) 2019-12-05 2021-06-10 漳州片仔癀药业股份有限公司 Crystal form of thieno[2,3-c]pyridazine-4(1h)-one compound, preparation method therefor and use thereof
CA3158745A1 (en) 2019-12-11 2021-06-17 Corcept Therapeutics Incorporated Methods of treating antipsychotic-induced weight gain with miricorilant
KR20220161438A (en) 2020-03-30 2022-12-06 길리애드 사이언시즈, 인코포레이티드 Cot inhibitor compound, (S)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1H-1,2,3-triazol-4-yl)2-methyl-1 Solid form of -oxo-1,2-dihydroisoquinolin-5-yl)methyl)))amino8-chloro-(neopentylamino)quinoline-3-carbonitrile
WO2021202688A1 (en) 2020-04-02 2021-10-07 Gilead Sciences, Inc. Process for preparing a cot inhibitor compound
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
CN111513022B (en) * 2020-05-08 2021-11-12 武汉市农业科学院 Breeding method of small-body meat ducks with low skin fat rate
KR20230013126A (en) 2020-05-21 2023-01-26 시오노기 앤드 컴파니, 리미티드 Medicines for the treatment of fatty liver disease
TWI838626B (en) 2020-06-03 2024-04-11 美商基利科學股份有限公司 Lpa receptor antagonists and uses thereof
WO2021247215A1 (en) 2020-06-03 2021-12-09 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
CN113967213A (en) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 Composition containing phenyl substituted ACC inhibitor and application thereof
CN113968871A (en) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 Crystalline forms of a phenyl-substituted ACC inhibitor
CN111888349B (en) * 2020-07-29 2021-10-22 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 Action of nimbin in preparing medicine for promoting survival of ischemic superlong random skin flap
WO2022166761A1 (en) * 2021-02-07 2022-08-11 正大天晴药业集团股份有限公司 Thienopyrimidine derivative
EP4304711A1 (en) 2021-03-11 2024-01-17 Gilead Sciences, Inc. Glp-1r modulating compounds
EP4313967A1 (en) 2021-03-29 2024-02-07 Gilead Sciences, Inc. Khk inhibitors
EP4344545A1 (en) 2021-04-28 2024-04-03 Nippon Soda Co., Ltd. Agricultural and horticultural fungicidal composition
CN117295717A (en) 2021-05-11 2023-12-26 吉利德科学公司 LPA receptor antagonists and uses thereof
US20220411406A1 (en) 2021-05-13 2022-12-29 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
TW202304435A (en) 2021-06-04 2023-02-01 美商基利科學股份有限公司 Methods of treating nash
TW202311256A (en) 2021-06-18 2023-03-16 美商基利科學股份有限公司 Il-31 modulators for treating fxr-induced pruritis
WO2023090411A1 (en) 2021-11-19 2023-05-25 塩野義製薬株式会社 Pharmaceutical for treating heart disease or skeletal muscle disease
CA3238094A1 (en) 2021-12-08 2023-06-15 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
WO2023106175A1 (en) * 2021-12-08 2023-06-15 日本曹達株式会社 Uracil compound, germicide for agricultural and horticultural use, nematicide, and antifungal agent for medical and animal use
US20240239807A1 (en) 2022-08-05 2024-07-18 Gilead Sciences, Inc. Sars-cov2 main protease inhibitors

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060084A (en) 1961-06-09 1962-10-23 Du Pont Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en) 1964-06-01 1967-01-24 Olin Mathieson Water soluble film containing agricultural chemicals
US3325503A (en) 1965-02-18 1967-06-13 Diamond Alkali Co Polychloro derivatives of mono- and dicyano pyridines and a method for their preparation
US3296272A (en) 1965-04-01 1967-01-03 Dow Chemical Co Sulfinyl- and sulfonylpyridines
US4144050A (en) 1969-02-05 1979-03-13 Hoechst Aktiengesellschaft Micro granules for pesticides and process for their manufacture
US3920442A (en) 1972-09-18 1975-11-18 Du Pont Water-dispersible pesticide aggregates
US4172714A (en) 1976-12-20 1979-10-30 E. I. Du Pont De Nemours And Company Dry compactible, swellable herbicidal compositions and pellets produced therefrom
GB2095558B (en) 1981-03-30 1984-10-24 Avon Packers Ltd Formulation of agricultural chemicals
DE3338292A1 (en) 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-AMINO-AZOLO (1,5-A) -PYRIMIDINE AND FUNGICIDES CONTAINING THEM
CA1249832A (en) 1984-02-03 1989-02-07 Shionogi & Co., Ltd. Azolyl cycloalkanol derivatives and agricultural fungicides
US5304732A (en) 1984-03-06 1994-04-19 Mgi Pharma, Inc. Herbicide resistance in plants
BR8600161A (en) 1985-01-18 1986-09-23 Plant Genetic Systems Nv CHEMICAL GENE, HYBRID, INTERMEDIATE PLASMIDIO VECTORS, PROCESS TO CONTROL INSECTS IN AGRICULTURE OR HORTICULTURE, INSECTICIDE COMPOSITION, PROCESS TO TRANSFORM PLANT CELLS TO EXPRESS A PLANTINIDE TOXIN, PRODUCED BY CULTURES, UNITED BY BACILLA
DE3545319A1 (en) 1985-12-20 1987-06-25 Basf Ag ACRYLIC ACID ESTERS AND FUNGICIDES THAT CONTAIN THESE COMPOUNDS
ES2018274T5 (en) 1986-03-11 1996-12-16 Plant Genetic Systems Nv VEGETABLE CELLS RESISTANT TO GLUTAMINE SYNTHETASE INHIBITORS, PREPARED BY GENETIC ENGINEERING.
US4670560A (en) 1986-04-28 1987-06-02 Ortho Pharmaceutical Corporation Thienopyrimidine-2,4-dione derivatives and intermediates thereof
CN1015981B (en) 1986-05-02 1992-03-25 施托福化学公司 Fungicidal pyridyl imidates
DE3782883T2 (en) 1986-08-12 1993-06-09 Mitsubishi Chem Ind PYRIDINE CARBOXAMIDE DERIVATIVES AND THEIR USE AS A FUNGICIDAL AGENT.
FR2629098B1 (en) 1988-03-23 1990-08-10 Rhone Poulenc Agrochimie CHEMICAL GENE OF HERBICIDE RESISTANCE
US5180587A (en) 1988-06-28 1993-01-19 E. I. Du Pont De Nemours And Company Tablet formulations of pesticides
NZ231804A (en) 1988-12-19 1993-03-26 Ciba Geigy Ag Insecticidal toxin from leiurus quinquestriatus hebraeus
JPH02225485A (en) * 1989-02-27 1990-09-07 Taiho Yakuhin Kogyo Kk Thienopyrimidine-3-acetic acid derivative
DE69034081T2 (en) 1989-03-24 2004-02-12 Syngenta Participations Ag Disease resistant transgenic plant
ES2166919T3 (en) 1989-08-30 2002-05-01 Kynoch Agrochemicals Proprieta PREPARATION OF A DOSING DEVICE.
DK0427529T3 (en) 1989-11-07 1995-06-26 Pioneer Hi Bred Int Larval killing lactins and plant insect resistance based thereon
US6187773B1 (en) 1989-11-10 2001-02-13 Agro-Kanesho Co., Ltd. Hexahydrotriazine compounds and insecticides
CA2083185A1 (en) 1990-03-12 1991-09-13 William Lawrence Geigle Water-dispersible or water-soluble pesticide granules from heat-activated binders
AU655197B2 (en) 1990-06-25 1994-12-08 Monsanto Technology Llc Glyphosate tolerant plants
ES2091878T3 (en) 1990-10-11 1996-11-16 Sumitomo Chemical Co PESTICIDE COMPOSITION.
JP2828186B2 (en) 1991-09-13 1998-11-25 宇部興産株式会社 Acrylate-based compounds, their preparation and fungicides
UA48104C2 (en) 1991-10-04 2002-08-15 Новартіс Аг Dna fragment including sequence that codes an insecticide protein with optimization for corn, dna fragment providing directed preferable for the stem core expression of the structural gene of the plant related to it, dna fragment providing specific for the pollen expression of related to it structural gene in the plant, recombinant dna molecule, method for obtaining a coding sequence of the insecticide protein optimized for corn, method of corn plants protection at least against one pest insect
DE4322211A1 (en) 1993-07-03 1995-01-12 Basf Ag Aqueous, multi-phase, stable ready-to-use formulation for crop protection agents and processes for their preparation
JP3811196B2 (en) * 1993-08-26 2006-08-16 武田薬品工業株式会社 Endothelin antagonist, thienopyrimidine derivative and process for producing the same
TW276256B (en) * 1993-08-26 1996-05-21 Takeda Pharm Industry Co Ltd
US5530195A (en) 1994-06-10 1996-06-25 Ciba-Geigy Corporation Bacillus thuringiensis gene encoding a toxin active against insects
JPH09110873A (en) * 1995-08-17 1997-04-28 Takeda Chem Ind Ltd Thienopyrimidine derivative, its production and use
ATE227726T1 (en) 1995-08-17 2002-11-15 Takeda Chemical Industries Ltd THIENOPYRIMIDENE DERIVATIVES AS ENDOTHELIN ANTAGONISTS
US5773704A (en) 1996-04-29 1998-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Herbicide resistant rice
EP0906115A1 (en) 1996-04-30 1999-04-07 Takeda Chemical Industries, Ltd. COMBINED USE OF GnRH AGONIST AND ANTAGONIST
JP2007302703A (en) * 1996-04-30 2007-11-22 Takeda Chem Ind Ltd Medicinal composition
ES2274546T3 (en) 1996-07-17 2007-05-16 Michigan State University SUGAR BEET PLANTS RESISTANT TO IMIDAZOLINONA HERBICIDE.
US5773702A (en) 1996-07-17 1998-06-30 Board Of Trustees Operating Michigan State University Imidazolinone herbicide resistant sugar beet plants
DE19650197A1 (en) 1996-12-04 1998-06-10 Bayer Ag 3-thiocarbamoylpyrazole derivatives
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
SE9702001D0 (en) * 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
US6984644B2 (en) * 1997-05-28 2006-01-10 Astrazeneca Ab Treatment of skin disorders using thieno[2,3-D]pyrimidinediones
JP2001516740A (en) 1997-09-18 2001-10-02 ビーエーエスエフ アクチェンゲゼルシャフト Novel benzamide oxime derivatives, their intermediates and production methods, and their use as fungicides
DE19750012A1 (en) 1997-11-12 1999-05-20 Bayer Ag Isothiazole carboxamides
WO1999027783A1 (en) 1997-12-04 1999-06-10 Dow Agrosciences Llc Fungicidal compositions and methods, and compounds and methods for the preparation thereof
DE19754082A1 (en) 1997-12-05 1999-06-10 Knoll Ag Method of combating obesity
US6348643B1 (en) 1998-10-29 2002-02-19 American Cyanamid Company DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use
CA2350968C (en) 1998-11-17 2008-10-28 Kumiai Chemical Industry Co., Ltd Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural fungicide
IT1303800B1 (en) 1998-11-30 2001-02-23 Isagro Ricerca Srl DIPEPTID COMPOUNDS HAVING HIGH FUNGICIDE AND AGRICULTURAL USE.
JP3417862B2 (en) 1999-02-02 2003-06-16 新東工業株式会社 Silica gel highly loaded with titanium oxide photocatalyst and method for producing the same
AU770077B2 (en) 1999-03-11 2004-02-12 Dow Agrosciences Llc Heterocyclic substituted isoxazolidines and their use as fungicides
MXPA01010143A (en) 1999-04-09 2003-07-14 Cell Therapeutics Inc Xanthine derivatives and analogs as cell signaling inhibitors.
US6586617B1 (en) 1999-04-28 2003-07-01 Sumitomo Chemical Takeda Agro Company, Limited Sulfonamide derivatives
UA73307C2 (en) 1999-08-05 2005-07-15 Куміаі Кемікал Індастрі Ко., Лтд. Carbamate derivative and fungicide of agricultural/horticultural destination
DE10021412A1 (en) 1999-12-13 2001-06-21 Bayer Ag Fungicidal active ingredient combinations
AR027928A1 (en) 2000-01-25 2003-04-16 Syngenta Participations Ag HERBICIDE COMPOSITION
US6376548B1 (en) 2000-01-28 2002-04-23 Rohm And Haas Company Enhanced propertied pesticides
IL167955A (en) 2000-02-04 2007-10-31 Sumitomo Chemical Co Heteroaryl substituted anilines
MX233208B (en) 2000-04-28 2005-12-20 Basf Ag Use of the maize x112 mutant ahas 2 gene and imidazolinone herbicides for selection of transgenic monocots, maize, rice and wheat plants resistant to the imidazolinone herbicides.
EP1311162B1 (en) 2000-08-25 2005-06-01 Syngenta Participations AG Bacillus thurigiensis crystal protein hybrids
WO2002022583A2 (en) 2000-09-18 2002-03-21 E. I. Du Pont De Nemours And Company Pyridinyl amides and imides for use as fungicides
CN100438865C (en) 2000-11-17 2008-12-03 美国陶氏益农公司 Compounds having fungicidal activity and processes to make and use same
JP2004518732A (en) 2001-02-14 2004-06-24 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Thieno'2,3-D pyrimidinedione derivatives as matrix metalloproteinase inhibitors
JP5034142B2 (en) 2001-04-20 2012-09-26 住友化学株式会社 Plant disease control composition
DE10136065A1 (en) 2001-07-25 2003-02-13 Bayer Cropscience Ag pyrazolylcarboxanilides
AR037228A1 (en) 2001-07-30 2004-11-03 Dow Agrosciences Llc ACID COMPOUNDS 6- (ARIL OR HETEROARIL) -4-AMYNOPYCOLINIC, HERBICIDE COMPOSITION THAT UNDERSTANDS AND METHOD TO CONTROL UNWANTED VEGETATION
FR2828196A1 (en) 2001-08-03 2003-02-07 Aventis Cropscience Sa New iodochromone derivatives, useful for the prevention or cure of plant fungal disorders, especially in cereals, vines, fruits, legumes or ornamental plants
UA104990C2 (en) 2001-08-09 2014-04-10 Юніверсіті Оф Саскачеван Wheat plant with increased resistance towards imidazolinone herbicides
TR201816453T4 (en) 2001-08-09 2018-11-21 Northwest Plant Breeding Company Wheat plants with increased resistance to imidazolinone herbicides.
AU2002322212B8 (en) 2001-08-09 2008-08-21 University Of Saskatchewan Wheat plants having increased resistance to imidazolinone herbicides
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
CA2457575C (en) 2001-08-17 2010-12-21 Sankyo Agro Company, Limited 3-phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same
US7230167B2 (en) 2001-08-31 2007-06-12 Syngenta Participations Ag Modified Cry3A toxins and nucleic acid sequences coding therefor
WO2003052073A2 (en) 2001-12-17 2003-06-26 Syngenta Participations Ag Novel corn event
WO2003053145A1 (en) 2001-12-21 2003-07-03 Nissan Chemical Industries, Ltd. Bactericidal composition
TWI327462B (en) 2002-01-18 2010-07-21 Sumitomo Chemical Co Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same
DE10204390A1 (en) 2002-02-04 2003-08-14 Bayer Cropscience Ag Disubstituted thiazolylcarboxanilides
EP1478437B1 (en) * 2002-02-27 2005-08-31 Pfizer Products Inc. Acc inhibitors
ES2288597T3 (en) 2002-03-05 2008-01-16 Syngenta Participations Ag O-CICLOPROPIL-CARBOXANILIDAS AND ITS USE AS FUNGICIDES.
WO2004016073A2 (en) 2002-07-10 2004-02-26 The Department Of Agriculture, Western Australia Wheat plants having increased resistance to imidazolinone herbicides
WO2004014916A1 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Pyrimidine fused bicyclic metalloproteinase inhibitors
GB0227966D0 (en) 2002-11-29 2003-01-08 Syngenta Participations Ag Organic Compounds
ATE425668T1 (en) * 2003-01-06 2009-04-15 Yissum Res Dev Co VEGETABLE ACETYL-COA CARBOXYLASE-INHIBITING HERBICIDES AS PESTICIDES
KR101074462B1 (en) * 2003-01-29 2011-10-18 다케다 야쿠힌 고교 가부시키가이샤 Thienopyrimidine compounds and use thereof
WO2004083193A1 (en) 2003-03-17 2004-09-30 Sumitomo Chemical Company, Limited Amide compound and bactericide composition containing the same
UA92716C2 (en) 2003-05-28 2010-12-10 Басф Акциенгезелльшафт Wheat plants with increased tolerance towards imidazolinone herbicides
WO2005020673A1 (en) 2003-08-29 2005-03-10 Instituto Nacional De Technologia Agropecuaria Rice plants having increased tolerance to imidazolinone herbicides
TWI355894B (en) 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
SI1725561T1 (en) 2004-03-10 2010-09-30 Basf Se 5,6-dialkyl-7-amino-triazolopyrimidines, method for their production, their use for controlling pathogenic fungi and agents containing said compounds
AP2006003778A0 (en) 2004-03-10 2006-10-31 Basf Ag 5,6-Dialkyl-7-amino-triazolopyrimidines, method for their production, their use for controlling pat hogenic fungi and agents containing said compounds
EP1750508A2 (en) 2004-06-03 2007-02-14 E.I.Du pont de nemours and company Fungicidal mixtures of amidinylphenyl compounds
CN1968935A (en) 2004-06-18 2007-05-23 巴斯福股份公司 1-methyl-3-trifluoromethyl-pyrazole-4-carboxylic acid (ortho-phenyl)-anilides and to use thereof as fungicide
WO2005123690A1 (en) 2004-06-18 2005-12-29 Basf Aktiengesellschaft 1-methyl-3-difluoromethyl-pyrazol-4-carbonic acid-(ortho-phenyl)-anilides, and use thereof as a fungicide
WO2006014647A2 (en) * 2004-07-21 2006-02-09 Athersys, Inc. Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof
GB0418048D0 (en) 2004-08-12 2004-09-15 Syngenta Participations Ag Method for protecting useful plants or plant propagation material
DE102005007160A1 (en) 2005-02-16 2006-08-24 Basf Ag Pyrazolecarboxylic acid anilides, process for their preparation and compositions containing them for controlling harmful fungi
AU2006215624A1 (en) 2005-02-16 2006-08-24 Basf Aktiengesellschaft 5-alkoxyalkyl-6-alkyl-7-amino-azolopyrimidines, method for their production, their use for controlling pathogenic fungi and agents containing said substances
DE102005009458A1 (en) 2005-03-02 2006-09-07 Bayer Cropscience Ag pyrazolylcarboxanilides
KR101379625B1 (en) 2006-01-13 2014-03-31 다우 아그로사이언시즈 엘엘씨 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides
WO2007090624A2 (en) 2006-02-09 2007-08-16 Syngenta Participations Ag A method of protecting a plant propagation material, a plant, and/or plant organs
US20070208040A1 (en) * 2006-03-02 2007-09-06 Elfatih Elzein A2a adenosine receptor antagonists
EP2151440A4 (en) * 2007-05-21 2010-10-20 Takeda Pharmaceutical Heterocyclic compound and use thereof
JP5535931B2 (en) * 2008-10-27 2014-07-02 武田薬品工業株式会社 Bicyclic compound
PT2519527E (en) * 2009-12-29 2014-02-17 Poxel Thieno[2,3-b]pyridinedione activators of ampk and therapeutic uses thereof
PL3628320T3 (en) * 2011-11-11 2022-07-25 Gilead Apollo, Llc Acc inhibitors and uses thereof
JP6417401B2 (en) * 2013-05-10 2018-11-07 ギリアド アポロ， エルエルシー ACC inhibitors and uses thereof
AR106472A1 (en) 2015-10-26 2018-01-17 Gilead Apollo Llc ACC INHIBITORS AND USES OF THE SAME
EP3379933B1 (en) 2015-11-25 2023-02-15 Gilead Apollo, LLC Fungicidal compositions containing derivatives of 2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine
CA3004798C (en) 2015-11-25 2023-10-31 Gilead Apollo, Llc Ester acc inhibitors and uses thereof
SI3380479T1 (en) 2015-11-25 2023-04-28 Gilead Apollo, Llc Triazole acc inhibitors and uses thereof
CA3004796C (en) 2015-11-25 2023-11-14 Gilead Apollo, Llc Pyrazole acc inhibitors and uses thereof
EP4364795A3 (en) 2016-03-02 2024-08-14 Gilead Apollo, LLC Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof

Also Published As

Publication number Publication date
CN104105485A (en) 2014-10-15
US9453026B2 (en) 2016-09-27
HK1201207A1 (en) 2015-08-28
EP2776038A1 (en) 2014-09-17
DK2776038T3 (en) 2018-04-23
US20130123231A1 (en) 2013-05-16
ES2665580T3 (en) 2018-04-26
PT2776038T (en) 2018-04-18
JP2019147847A (en) 2019-09-05
HRP20192202T1 (en) 2020-03-06
PL2776038T3 (en) 2018-06-29
EA201490826A1 (en) 2015-01-30
EP3628320B1 (en) 2022-03-16
EP3329919A1 (en) 2018-06-06
EP2776038A4 (en) 2015-04-01
SI3329919T1 (en) 2020-02-28
NZ723933A (en) 2018-03-23
US20190016732A1 (en) 2019-01-17
CN106905346B (en) 2019-05-28
PL3628320T3 (en) 2022-07-25
US20150203510A1 (en) 2015-07-23
CN106905346A (en) 2017-06-30
JP6276442B2 (en) 2018-02-07
JP6114297B2 (en) 2017-04-12
TWI701253B (en) 2020-08-11
MX2014005693A (en) 2014-11-26
ES2912574T3 (en) 2022-05-26
EP3628320A1 (en) 2020-04-01
CY1122657T1 (en) 2021-03-12
ZA201704192B (en) 2021-10-27
CL2014001241A1 (en) 2014-11-28
JP6756014B2 (en) 2020-09-16
AU2017265088B2 (en) 2019-08-08
US8969557B2 (en) 2015-03-03
AU2017265088A1 (en) 2017-12-14
EP3329919A8 (en) 2020-10-07
NZ738735A (en) 2019-08-30
KR102033806B1 (en) 2019-10-17
NZ624819A (en) 2016-10-28
AU2019253834A1 (en) 2019-11-14
ZA201704173B (en) 2021-08-25
LT3329919T (en) 2020-02-10
MX2020000331A (en) 2022-03-16
US20200102323A1 (en) 2020-04-02
US10472374B2 (en) 2019-11-12
ZA201403633B (en) 2021-10-27
LT2776038T (en) 2018-04-25
KR20190041027A (en) 2019-04-19
KR102172902B1 (en) 2020-11-02
AU2012335088A1 (en) 2014-05-29
JP6543358B2 (en) 2019-07-10
TWI582095B (en) 2017-05-11
JP2014533281A (en) 2014-12-11
EA033598B1 (en) 2019-11-07
TWI655193B (en) 2019-04-01
CY1120224T1 (en) 2018-12-12
JP2018052989A (en) 2018-04-05
CN109970760A (en) 2019-07-05
TW201350489A (en) 2013-12-16
RS57157B1 (en) 2018-07-31
CN109970760B (en) 2022-04-26
BR122019026836B1 (en) 2021-02-23
DK3329919T3 (en) 2019-12-09
EA201692104A1 (en) 2017-08-31
PL3329919T3 (en) 2020-05-18
AU2012335088B2 (en) 2017-08-24
KR20190143473A (en) 2019-12-30
TW201930310A (en) 2019-08-01
CA2855372C (en) 2022-03-22
TWI612050B (en) 2018-01-21
WO2013071169A1 (en) 2013-05-16
US20160297834A1 (en) 2016-10-13
HUE037444T2 (en) 2018-09-28
BR112014011351A2 (en) 2017-06-06
JP2017114910A (en) 2017-06-29
KR102060290B1 (en) 2019-12-27
TW201720831A (en) 2017-06-16
CA2855372A1 (en) 2013-05-16
KR20140106554A (en) 2014-09-03
SI2776038T1 (en) 2018-06-29
US9944655B2 (en) 2018-04-17
EP2776038B1 (en) 2018-01-10
ES2767956T3 (en) 2020-06-19
EP3329919B1 (en) 2019-11-06
HUE047049T2 (en) 2020-04-28
EA030264B1 (en) 2018-07-31
PT3329919T (en) 2020-01-20
UA123760C2 (en) 2021-06-02
UA114901C2 (en) 2017-08-28
BR112014011351B1 (en) 2021-02-17
MX344490B (en) 2016-12-16
HRP20180534T1 (en) 2018-05-04
AU2019253834B2 (en) 2021-04-29
CN104105485B (en) 2017-04-12
TW201831492A (en) 2018-09-01

Similar Documents

Publication Publication Date Title
MX2020000331A (en) Acc inhibitors and uses thereof.
EP4364795A3 (en) Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
MX2015015416A (en) Acc inhibitors and uses thereof.
MX2018005292A (en) Acc inhibitors and uses thereof.
GEP20166432B (en) 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
MX2015015421A (en) Acc inhibitors and uses thereof.
MX340756B (en) Quinazoline compounds as serine/threonine kinase inhibitors.
MX2015015417A (en) Acc inhibitors and uses thereof.
MX2012000709A (en) Pyrrolopyridine inhibitors of kinases.
MX355088B (en) Thienopyrimidine inhibitors of atypical protein kinase c.
UA111382C2 (en) Protein kinase inhibitors
MX340402B (en) Tricyclic inhibitors of kinases.
EP4219465A3 (en) Prmt5 inhibitors and uses thereof
TN2016000270A1 (en) Heteroaryls and uses thereof.
MX2012004780A (en) Akt inhibitors.
GEP20166474B (en) Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors
WO2014153235A3 (en) Arginine methyltransferase inhibitors and uses thereof
WO2014153100A3 (en) Arginine methyltransferase inhibitors and uses thereof
WO2012142498A3 (en) Mif inhibitors and their uses
MX2014001879A (en) Amino quinazolines as kinase inhibitors.
WO2012122383A3 (en) Pi3 kinase inhibitors and uses thereof
MX341456B (en) Amino-quinolines as kinase inhibitors.
UA111744C2 (en) REPLACED PYRIDOPORASINS AS SYK INHIBITORS
WO2012090219A3 (en) Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors
CA2836511C (en) Matriptase inhibitors and uses thereof against orthomyxoviridae infections