MX367908B - Proceso para preparar intermediarios sinteticos para preparar derivados de tetrahidroquinolina. - Google Patents
Proceso para preparar intermediarios sinteticos para preparar derivados de tetrahidroquinolina.Info
- Publication number
- MX367908B MX367908B MX2017001930A MX2017001930A MX367908B MX 367908 B MX367908 B MX 367908B MX 2017001930 A MX2017001930 A MX 2017001930A MX 2017001930 A MX2017001930 A MX 2017001930A MX 367908 B MX367908 B MX 367908B
- Authority
- MX
- Mexico
- Prior art keywords
- preparing
- synthetic intermediates
- tetrahydroquinoline derivatives
- derivatives
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2014050556 | 2014-08-12 | ||
| PCT/NL2015/050555 WO2016024858A1 (fr) | 2014-08-12 | 2015-07-29 | Procédé de préparation d'intermédiaires synthétiques pour la préparation de dérivés de tétrahydroquinoléine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017001930A MX2017001930A (es) | 2018-03-01 |
| MX367908B true MX367908B (es) | 2019-09-11 |
Family
ID=51429345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017001930A MX367908B (es) | 2014-08-12 | 2015-07-29 | Proceso para preparar intermediarios sinteticos para preparar derivados de tetrahidroquinolina. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10112904B2 (fr) |
| EP (2) | EP3180314B1 (fr) |
| JP (1) | JP6670310B2 (fr) |
| KR (1) | KR102572626B1 (fr) |
| CN (1) | CN107108558B (fr) |
| AR (1) | AR101509A1 (fr) |
| AU (1) | AU2015302407B2 (fr) |
| BR (1) | BR112017002873B1 (fr) |
| CA (1) | CA2958040C (fr) |
| CL (1) | CL2017000367A1 (fr) |
| DK (1) | DK3180314T3 (fr) |
| EA (1) | EA034357B1 (fr) |
| ES (1) | ES2926775T3 (fr) |
| HR (1) | HRP20221061T1 (fr) |
| HU (1) | HUE059947T2 (fr) |
| IL (1) | IL250525B (fr) |
| LT (1) | LT3180314T (fr) |
| MA (1) | MA40378B1 (fr) |
| MX (1) | MX367908B (fr) |
| PL (1) | PL3180314T3 (fr) |
| PT (1) | PT3180314T (fr) |
| RS (1) | RS63575B1 (fr) |
| SG (1) | SG11201701077XA (fr) |
| SI (1) | SI3180314T1 (fr) |
| TW (1) | TWI691490B (fr) |
| WO (1) | WO2016024858A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022185120A1 (fr) | 2021-03-05 | 2022-09-09 | Newamsterdam Pharma B.V. | Obicetrapib pour le traitement de démences |
| KR20240040767A (ko) | 2021-07-26 | 2024-03-28 | 뉴암스테르담 파마 비.브이. | His 저감반응자의 치료 |
| WO2023129595A1 (fr) | 2021-12-30 | 2023-07-06 | Newamsterdam Pharma B.V. | Combinaison d'obicetrapib et d'inhibiteur de sglt2 |
| TW202409008A (zh) | 2022-07-05 | 2024-03-01 | 荷蘭商新阿姆斯特丹製藥公司 | 奧比特拉(obicetrapib)鹽及彼等之製造方法與中間體 |
| WO2024042061A1 (fr) | 2022-08-22 | 2024-02-29 | Newamsterdam Pharma B.V. | Polythérapie d'obicetrapib et d'ézétimibe et compositions pharmaceutiques à dose fixe |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197786B1 (en) * | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| AU2002253448B2 (en) * | 2001-04-30 | 2007-07-05 | Pfizer Products Inc. | Compounds useful as intermediates for 4-aminoquinoline derivatives |
| UA90269C2 (ru) * | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| TW200808731A (en) * | 2006-03-30 | 2008-02-16 | Tanabe Seiyaku Co | A process for preparing tetrahydroquinoline derivatives |
| CN101466679A (zh) * | 2006-03-30 | 2009-06-24 | 田边三菱制药株式会社 | 制备四氢喹啉衍生物的方法 |
-
2015
- 2015-07-29 DK DK15767345.0T patent/DK3180314T3/da active
- 2015-07-29 CA CA2958040A patent/CA2958040C/fr active Active
- 2015-07-29 CN CN201580046606.1A patent/CN107108558B/zh active Active
- 2015-07-29 RS RS20220810A patent/RS63575B1/sr unknown
- 2015-07-29 SG SG11201701077XA patent/SG11201701077XA/en unknown
- 2015-07-29 MX MX2017001930A patent/MX367908B/es active IP Right Grant
- 2015-07-29 PT PT157673450T patent/PT3180314T/pt unknown
- 2015-07-29 AU AU2015302407A patent/AU2015302407B2/en active Active
- 2015-07-29 WO PCT/NL2015/050555 patent/WO2016024858A1/fr active Application Filing
- 2015-07-29 HU HUE15767345A patent/HUE059947T2/hu unknown
- 2015-07-29 EP EP15767345.0A patent/EP3180314B1/fr active Active
- 2015-07-29 PL PL15767345.0T patent/PL3180314T3/pl unknown
- 2015-07-29 BR BR112017002873-5A patent/BR112017002873B1/pt active IP Right Grant
- 2015-07-29 ES ES15767345T patent/ES2926775T3/es active Active
- 2015-07-29 SI SI201531874T patent/SI3180314T1/sl unknown
- 2015-07-29 HR HRP20221061TT patent/HRP20221061T1/hr unknown
- 2015-07-29 EP EP22179712.9A patent/EP4083022A1/fr active Pending
- 2015-07-29 MA MA40378A patent/MA40378B1/fr unknown
- 2015-07-29 JP JP2017528754A patent/JP6670310B2/ja active Active
- 2015-07-29 US US15/503,686 patent/US10112904B2/en active Active
- 2015-07-29 KR KR1020177006422A patent/KR102572626B1/ko active IP Right Grant
- 2015-07-29 EA EA201790364A patent/EA034357B1/ru active IP Right Revival
- 2015-07-29 LT LTEPPCT/NL2015/050555T patent/LT3180314T/lt unknown
- 2015-08-10 TW TW104125888A patent/TWI691490B/zh active
- 2015-08-11 AR ARP150102597A patent/AR101509A1/es unknown
-
2017
- 2017-02-09 IL IL250525A patent/IL250525B/en active IP Right Grant
- 2017-02-10 CL CL2017000367A patent/CL2017000367A1/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2019268063A1 (en) | Compositions for modulating sod-1 expression | |
| EP3389725A4 (fr) | Compositions et méthodes pour le traitement de maladies du système nerveux central | |
| EP3177732A4 (fr) | Compositions et procédés pour le traitement de maladies et états pathologiques ophthalmiques | |
| EP3261440A4 (fr) | Méthodes et compositions de traitement de maladies oculaires génétiques | |
| EP3390634A4 (fr) | Compositions et méthodes pour le traitement de maladies oculaires | |
| PH12016501441A1 (en) | Chimeric alkaline phosphate-like proteins | |
| EP3119913A4 (fr) | Procédés et compositions pour le traitement de maladies immunitaires ou de troubles et/ou la surveillance thérapeutique | |
| EP3377090A4 (fr) | Méthodes de traitement de troubles associés aux acides biliaires | |
| EP3503906A4 (fr) | Méthodes de traitement de troubles associés aux acides biliaires | |
| EP3096617A4 (fr) | Compositions et méthodes de traitement de maladies oculaires | |
| EP3157531A4 (fr) | Procédés et compositions pour la stimulation du système entéro-endocrinien intestinal pour le traitement de maladies ou d'états pathologiques associées à celui-ci | |
| MX2017001930A (es) | Proceso para preparar intermediarios sinteticos para preparar derivados de tetrahidroquinolina. | |
| EP3182989A4 (fr) | Méthodes et compositions destinées à prévenir et à traiter une maladie | |
| EP3182979A4 (fr) | Nouvelles compositions et méthodes utiles pour traiter ou prévenir des maladies ou des troubles hépatiques et favoriser la perte de poids | |
| EP3110446A4 (fr) | Procédés et compositions pour le traitement de maladies associées à siglec-8 | |
| EP3131556A4 (fr) | Méthodes et compositions pour le traitement de maladies liées à la bpco | |
| EP3263119A4 (fr) | Composition comprenant des vésicules extracellulaires dérivées de bactéries de bacillus sp. pour le traitement de maladies associées à la grossesse | |
| EP3348273B8 (fr) | Compositions à base de protéines et de xyloglucane pour le traitement de troubles intestinaux | |
| EP3192875A4 (fr) | Composition pharmaceutique à libération prolongée destinée au traitement et à la prévention de maladies ophtalmiques | |
| EP3169405A4 (fr) | Méthodes, composés et compositions pour le traitement de maladies musculo-squelettiques | |
| EP3164132A4 (fr) | Méthodes et compositions pour le traitement de maladies et d'affections | |
| EP3326638A4 (fr) | Composition pharmaceutique pour la prévention ou le traitement de maladies médiées par il-6 comprenant un extrait de fleur derosa rugosa | |
| EP3501524A4 (fr) | Utilisation de la phytosphingosine-1-phosphate ou d'un dérivé de celle-ci en tant qu'activateur immunitaire ou composition pharmaceutique pour le traitement de la démence | |
| EP3156054A4 (fr) | Médicament pour la prévention et/ou le traitement de maladies induites par le stress | |
| EP3107534A4 (fr) | Compositions et procédés pour le traitement de maladies neurodégénératives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |