MA40378A - Procédé de préparation d'intermédiaires synthétiques pour la préparation de dérivés de tétrahydroquinoléine - Google Patents
Procédé de préparation d'intermédiaires synthétiques pour la préparation de dérivés de tétrahydroquinoléineInfo
- Publication number
- MA40378A MA40378A MA040378A MA40378A MA40378A MA 40378 A MA40378 A MA 40378A MA 040378 A MA040378 A MA 040378A MA 40378 A MA40378 A MA 40378A MA 40378 A MA40378 A MA 40378A
- Authority
- MA
- Morocco
- Prior art keywords
- preparing
- synthetic intermediates
- tetrahydroquinoline derivatives
- derivatives
- preparation
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 125000000147 tetrahydroquinolinyl group Chemical class N1(CCCC2=CC=CC=C12)* 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La présente invention concerne un procédé pour la préparation d'intermédiaires synthétiques qui peuvent être utilisés dans la préparation de dérivés de la tétrahydroquinoléine, lesquels dérivés ont une activité inhibitrice à l'encontre de la protéine de transfert de cholestéryle (cetp), présentent des effets d'augmentation du taux de cholestérol hdl et de diminution du taux de cholestérol ldl, et peuvent être utilisés pour le traitement et/ou la prévention de maladies telles que des maladies artérioscléro
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2014050556 | 2014-08-12 | ||
| PCT/NL2015/050555 WO2016024858A1 (fr) | 2014-08-12 | 2015-07-29 | Procédé de préparation d'intermédiaires synthétiques pour la préparation de dérivés de tétrahydroquinoléine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA40378A true MA40378A (fr) | 2017-06-21 |
| MA40378B1 MA40378B1 (fr) | 2022-10-31 |
Family
ID=51429345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA40378A MA40378B1 (fr) | 2014-08-12 | 2015-07-29 | Procédé de préparation d'intermédiaires synthétiques pour la préparation de dérivés de la tétrahydroquinoléine |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US10112904B2 (fr) |
| EP (2) | EP4083022A1 (fr) |
| JP (1) | JP6670310B2 (fr) |
| KR (1) | KR102572626B1 (fr) |
| CN (1) | CN107108558B (fr) |
| AR (1) | AR101509A1 (fr) |
| AU (1) | AU2015302407B2 (fr) |
| BR (1) | BR112017002873B1 (fr) |
| CA (1) | CA2958040C (fr) |
| CL (1) | CL2017000367A1 (fr) |
| DK (1) | DK3180314T3 (fr) |
| EA (1) | EA034357B1 (fr) |
| ES (1) | ES2926775T3 (fr) |
| HR (1) | HRP20221061T1 (fr) |
| HU (1) | HUE059947T2 (fr) |
| IL (1) | IL250525B (fr) |
| LT (1) | LT3180314T (fr) |
| MA (1) | MA40378B1 (fr) |
| MX (1) | MX367908B (fr) |
| PL (1) | PL3180314T3 (fr) |
| PT (1) | PT3180314T (fr) |
| RS (1) | RS63575B1 (fr) |
| SG (1) | SG11201701077XA (fr) |
| SI (1) | SI3180314T1 (fr) |
| SM (1) | SMT202200385T1 (fr) |
| TW (1) | TWI691490B (fr) |
| WO (1) | WO2016024858A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE067276T2 (hu) | 2021-03-05 | 2024-10-28 | Newamsterdam Pharma B V | Obicetrapib demenciák kezelésére |
| CN117940125A (zh) | 2021-07-26 | 2024-04-26 | 新阿姆斯特丹制药私人有限公司 | His弱应答者的治疗 |
| WO2023129595A1 (fr) | 2021-12-30 | 2023-07-06 | Newamsterdam Pharma B.V. | Combinaison d'obicetrapib et d'inhibiteur de sglt2 |
| MA71399A (fr) | 2022-07-05 | 2025-04-30 | Newamsterdam Pharma B.V. | Sels d'obicetrapib et leurs procédé de fabrication et leurs intermédiaires |
| WO2024042061A1 (fr) | 2022-08-22 | 2024-02-29 | Newamsterdam Pharma B.V. | Polythérapie d'obicetrapib et d'ézétimibe et compositions pharmaceutiques à dose fixe |
| EP4661865A1 (fr) | 2023-02-07 | 2025-12-17 | NewAmsterdam Pharma B.V. | Traitement combiné d'obicétrapib et d'ézétimibe et compositions pharmaceutiques à dose fixe |
| WO2025059594A1 (fr) | 2023-09-15 | 2025-03-20 | Newamsterdam Pharma B.V. | Méthodes de traitement de l'hypercholestérolémie familiale hétérozygote (hefh) |
| WO2025093436A1 (fr) | 2023-11-01 | 2025-05-08 | Newamsterdam Pharma B.V. | Traitement et prévention de la dégénérescence maculaire liée à l'âge à l'aide d'un inhibiteur de cetp |
| WO2025093129A1 (fr) | 2023-11-01 | 2025-05-08 | Newamsterdam Pharma B.V. | Traitement et prévention de la dégénérescence maculaire liée à l'âge à l'aide d'un inhibiteur de la cetp |
| WO2025146262A1 (fr) | 2024-01-03 | 2025-07-10 | Newamsterdam Pharma B.V. | Obicetrapib destiné à être utilisé dans le traitement d'hémoglobinopathies |
| WO2025146415A1 (fr) | 2024-01-03 | 2025-07-10 | Newamsterdam Pharma B.V. | Amélioration de caractéristiques de plaque athéroscléreuse avec de l'obicetrapib |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197786B1 (en) * | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| DK1383734T3 (da) * | 2001-04-30 | 2006-05-15 | Pfizer Prod Inc | Forbindelser, der er anvendelige som mellemprodukter til 4-aminoquinolinderivater |
| UA90269C2 (ru) * | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| TW200808731A (en) * | 2006-03-30 | 2008-02-16 | Tanabe Seiyaku Co | A process for preparing tetrahydroquinoline derivatives |
| CN101466679A (zh) * | 2006-03-30 | 2009-06-24 | 田边三菱制药株式会社 | 制备四氢喹啉衍生物的方法 |
-
2015
- 2015-07-29 LT LTEPPCT/NL2015/050555T patent/LT3180314T/lt unknown
- 2015-07-29 HR HRP20221061TT patent/HRP20221061T1/hr unknown
- 2015-07-29 MX MX2017001930A patent/MX367908B/es active IP Right Grant
- 2015-07-29 DK DK15767345.0T patent/DK3180314T3/da active
- 2015-07-29 US US15/503,686 patent/US10112904B2/en active Active
- 2015-07-29 JP JP2017528754A patent/JP6670310B2/ja active Active
- 2015-07-29 AU AU2015302407A patent/AU2015302407B2/en active Active
- 2015-07-29 RS RS20220810A patent/RS63575B1/sr unknown
- 2015-07-29 PT PT157673450T patent/PT3180314T/pt unknown
- 2015-07-29 KR KR1020177006422A patent/KR102572626B1/ko active Active
- 2015-07-29 EA EA201790364A patent/EA034357B1/ru active IP Right Revival
- 2015-07-29 ES ES15767345T patent/ES2926775T3/es active Active
- 2015-07-29 WO PCT/NL2015/050555 patent/WO2016024858A1/fr not_active Ceased
- 2015-07-29 EP EP22179712.9A patent/EP4083022A1/fr active Pending
- 2015-07-29 BR BR112017002873-5A patent/BR112017002873B1/pt active IP Right Grant
- 2015-07-29 PL PL15767345.0T patent/PL3180314T3/pl unknown
- 2015-07-29 CA CA2958040A patent/CA2958040C/fr active Active
- 2015-07-29 EP EP15767345.0A patent/EP3180314B1/fr active Active
- 2015-07-29 SI SI201531874T patent/SI3180314T1/sl unknown
- 2015-07-29 SG SG11201701077XA patent/SG11201701077XA/en unknown
- 2015-07-29 MA MA40378A patent/MA40378B1/fr unknown
- 2015-07-29 CN CN201580046606.1A patent/CN107108558B/zh active Active
- 2015-07-29 SM SM20220385T patent/SMT202200385T1/it unknown
- 2015-07-29 HU HUE15767345A patent/HUE059947T2/hu unknown
- 2015-08-10 TW TW104125888A patent/TWI691490B/zh active
- 2015-08-11 AR ARP150102597A patent/AR101509A1/es active IP Right Grant
-
2017
- 2017-02-09 IL IL250525A patent/IL250525B/en active IP Right Grant
- 2017-02-10 CL CL2017000367A patent/CL2017000367A1/es unknown
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