SG11201701077XA - Process for preparing synthetic intermediates for preparing tetrahydroquinoline derivatives - Google Patents
Process for preparing synthetic intermediates for preparing tetrahydroquinoline derivativesInfo
- Publication number
- SG11201701077XA SG11201701077XA SG11201701077XA SG11201701077XA SG11201701077XA SG 11201701077X A SG11201701077X A SG 11201701077XA SG 11201701077X A SG11201701077X A SG 11201701077XA SG 11201701077X A SG11201701077X A SG 11201701077XA SG 11201701077X A SG11201701077X A SG 11201701077XA
- Authority
- SG
- Singapore
- Prior art keywords
- preparing
- synthetic intermediates
- tetrahydroquinoline derivatives
- derivatives
- preparing synthetic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2014050556 | 2014-08-12 | ||
| PCT/NL2015/050555 WO2016024858A1 (fr) | 2014-08-12 | 2015-07-29 | Procédé de préparation d'intermédiaires synthétiques pour la préparation de dérivés de tétrahydroquinoléine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201701077XA true SG11201701077XA (en) | 2017-03-30 |
Family
ID=51429345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201701077XA SG11201701077XA (en) | 2014-08-12 | 2015-07-29 | Process for preparing synthetic intermediates for preparing tetrahydroquinoline derivatives |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10112904B2 (fr) |
| EP (2) | EP3180314B1 (fr) |
| JP (1) | JP6670310B2 (fr) |
| KR (1) | KR102572626B1 (fr) |
| CN (1) | CN107108558B (fr) |
| AR (1) | AR101509A1 (fr) |
| AU (1) | AU2015302407B2 (fr) |
| BR (1) | BR112017002873B1 (fr) |
| CA (1) | CA2958040C (fr) |
| CL (1) | CL2017000367A1 (fr) |
| DK (1) | DK3180314T3 (fr) |
| EA (1) | EA034357B1 (fr) |
| ES (1) | ES2926775T3 (fr) |
| HR (1) | HRP20221061T1 (fr) |
| HU (1) | HUE059947T2 (fr) |
| IL (1) | IL250525B (fr) |
| LT (1) | LT3180314T (fr) |
| MA (1) | MA40378B1 (fr) |
| MX (1) | MX367908B (fr) |
| PL (1) | PL3180314T3 (fr) |
| PT (1) | PT3180314T (fr) |
| RS (1) | RS63575B1 (fr) |
| SG (1) | SG11201701077XA (fr) |
| SI (1) | SI3180314T1 (fr) |
| TW (1) | TWI691490B (fr) |
| WO (1) | WO2016024858A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112023017999A2 (pt) | 2021-03-05 | 2023-11-14 | Newamsterdam Pharma B V | Obicetrapibe para tratamento de demências |
| AU2022320869A1 (en) | 2021-07-26 | 2024-02-01 | Newamsterdam Pharma B.V. | Treatment of his hyporesponders |
| AU2022425078A1 (en) | 2021-12-30 | 2024-08-08 | Newamsterdam Pharma B.V. | Obicetrapib and sglt2 inhibitor combination |
| TW202409008A (zh) | 2022-07-05 | 2024-03-01 | 荷蘭商新阿姆斯特丹製藥公司 | 奧比特拉(obicetrapib)鹽及彼等之製造方法與中間體 |
| WO2024042061A1 (fr) | 2022-08-22 | 2024-02-29 | Newamsterdam Pharma B.V. | Polythérapie d'obicetrapib et d'ézétimibe et compositions pharmaceutiques à dose fixe |
| WO2024165395A1 (fr) | 2023-02-07 | 2024-08-15 | Newamsterdam Pharma B.V. | Traitement combiné d'obicétrapib et d'ézétimibe et compositions pharmaceutiques à dose fixe |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197786B1 (en) | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| CN1267411C (zh) * | 2001-04-30 | 2006-08-02 | 辉瑞产品公司 | 用作4－氨基喹啉衍生物中间体的化合物 |
| UA90269C2 (ru) * | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| CN101466679A (zh) * | 2006-03-30 | 2009-06-24 | 田边三菱制药株式会社 | 制备四氢喹啉衍生物的方法 |
| UY30244A1 (es) * | 2006-03-30 | 2007-11-30 | Tanabe Seiyaku Co | Un proceso para preparar derivados de tetrahidroquinolina |
-
2015
- 2015-07-29 ES ES15767345T patent/ES2926775T3/es active Active
- 2015-07-29 HU HUE15767345A patent/HUE059947T2/hu unknown
- 2015-07-29 SG SG11201701077XA patent/SG11201701077XA/en unknown
- 2015-07-29 EP EP15767345.0A patent/EP3180314B1/fr active Active
- 2015-07-29 WO PCT/NL2015/050555 patent/WO2016024858A1/fr active Application Filing
- 2015-07-29 LT LTEPPCT/NL2015/050555T patent/LT3180314T/lt unknown
- 2015-07-29 EA EA201790364A patent/EA034357B1/ru active IP Right Revival
- 2015-07-29 MX MX2017001930A patent/MX367908B/es active IP Right Grant
- 2015-07-29 MA MA40378A patent/MA40378B1/fr unknown
- 2015-07-29 HR HRP20221061TT patent/HRP20221061T1/hr unknown
- 2015-07-29 DK DK15767345.0T patent/DK3180314T3/da active
- 2015-07-29 KR KR1020177006422A patent/KR102572626B1/ko active IP Right Grant
- 2015-07-29 BR BR112017002873-5A patent/BR112017002873B1/pt active IP Right Grant
- 2015-07-29 CN CN201580046606.1A patent/CN107108558B/zh active Active
- 2015-07-29 US US15/503,686 patent/US10112904B2/en active Active
- 2015-07-29 CA CA2958040A patent/CA2958040C/fr active Active
- 2015-07-29 PL PL15767345.0T patent/PL3180314T3/pl unknown
- 2015-07-29 SI SI201531874T patent/SI3180314T1/sl unknown
- 2015-07-29 PT PT157673450T patent/PT3180314T/pt unknown
- 2015-07-29 AU AU2015302407A patent/AU2015302407B2/en active Active
- 2015-07-29 RS RS20220810A patent/RS63575B1/sr unknown
- 2015-07-29 EP EP22179712.9A patent/EP4083022A1/fr active Pending
- 2015-07-29 JP JP2017528754A patent/JP6670310B2/ja active Active
- 2015-08-10 TW TW104125888A patent/TWI691490B/zh active
- 2015-08-11 AR ARP150102597A patent/AR101509A1/es unknown
-
2017
- 2017-02-09 IL IL250525A patent/IL250525B/en active IP Right Grant
- 2017-02-10 CL CL2017000367A patent/CL2017000367A1/es unknown
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