MX366762B - Composición de conjugado multivalente de polisacarido-proteina de pneumococo. - Google Patents
Composición de conjugado multivalente de polisacarido-proteina de pneumococo.Info
- Publication number
- MX366762B MX366762B MX2015007301A MX2015007301A MX366762B MX 366762 B MX366762 B MX 366762B MX 2015007301 A MX2015007301 A MX 2015007301A MX 2015007301 A MX2015007301 A MX 2015007301A MX 366762 B MX366762 B MX 366762B
- Authority
- MX
- Mexico
- Prior art keywords
- serotypes
- protein conjugate
- conjugate composition
- pneumococcal polysaccharide
- multivalent pneumococcal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a una composición inmunogénica que comprende 13 conjugados diferentes de proteína-polisacárido. Cada uno de los conjugados comprende un polisacárido capsular preparado a partir de un serotipo diferente de Streptococcus pneumoniae conjugado con proteína portadora, es decir, 12 serotipos seleccionados del grupo constituido por 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19ª, 19F, 23F, y el serotipo 22F o 33F. La composición inmunogénica formulada en una vacuna que comprende un adyuvante basado en aluminio incrementa la cobertura respecto a enfermedades neumocócicas en bebés y niños.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020120143318A KR20140075201A (ko) | 2012-12-11 | 2012-12-11 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
PCT/KR2013/011195 WO2014092378A1 (ko) | 2012-12-11 | 2013-12-05 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015007301A MX2015007301A (es) | 2016-01-20 |
MX366762B true MX366762B (es) | 2019-07-23 |
Family
ID=50934609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015007301A MX366762B (es) | 2012-12-11 | 2013-12-05 | Composición de conjugado multivalente de polisacarido-proteina de pneumococo. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20150343076A1 (es) |
EP (1) | EP2932980B1 (es) |
JP (1) | JP2016503016A (es) |
KR (1) | KR20140075201A (es) |
CN (1) | CN104837504A (es) |
BR (1) | BR112015013513B1 (es) |
CA (1) | CA2894532C (es) |
CO (1) | CO7461130A2 (es) |
DK (1) | DK2932980T3 (es) |
ES (1) | ES2881541T3 (es) |
MX (1) | MX366762B (es) |
PH (1) | PH12015501270A1 (es) |
PL (1) | PL2932980T3 (es) |
PT (1) | PT2932980T (es) |
RU (1) | RU2613148C2 (es) |
WO (1) | WO2014092378A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ME01334B (me) | 2005-04-08 | 2013-12-20 | Wyeth Llc | Polivalentni pripravak konjugata pneumokoknog polisaharida s proteinom |
WO2015110940A2 (en) | 2014-01-21 | 2015-07-30 | Pfizer Inc. | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
US11160855B2 (en) * | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
TWI718144B (zh) | 2015-05-04 | 2021-02-11 | 美商輝瑞股份有限公司 | B型鏈球菌多醣-蛋白質軛合物、製造軛合物之方法、含軛合物之免疫原性組成物、及其用途 |
SI3313436T1 (sl) | 2015-06-23 | 2021-09-30 | Biological E Limited | Multivalentno konjugirano pnevmokokno cepivo |
KR102225282B1 (ko) * | 2015-07-21 | 2021-03-10 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
US10159728B2 (en) | 2015-09-10 | 2018-12-25 | Inventprise, Llc | Multivalent VLP conjugates |
CA3000201A1 (en) * | 2015-10-07 | 2017-04-13 | Boehringer Ingelheim Vetmedica, Inc. | Streptococcus suis polysacchari de-protein conjugate composition |
JP2019529497A (ja) * | 2016-09-30 | 2019-10-17 | バイオロジカル イー リミテッド | 多糖類−タンパク質コンジュゲートを含む多価肺炎球菌ワクチン組成物 |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
MA47223A (fr) | 2016-12-30 | 2019-11-06 | Sutrovax Inc | Conjugués polypeptide-antigène avec des acides aminés non naturels |
CA3050120A1 (en) * | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
KR20200051005A (ko) | 2017-09-07 | 2020-05-12 | 머크 샤프 앤드 돔 코포레이션 | 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도 |
MX2020002557A (es) | 2017-09-07 | 2020-07-13 | Merck Sharp & Dohme | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina. |
SG11202005255PA (en) | 2017-12-06 | 2020-07-29 | Merck Sharp & Dohme | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
CN108159408A (zh) * | 2017-12-29 | 2018-06-15 | 云南沃森生物技术股份有限公司 | 一种多价肺炎球菌多糖-蛋白结合物组合物及其制备方法和应用 |
AU2019215216A1 (en) | 2018-02-05 | 2020-07-23 | Sk Bioscience Co., Ltd. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US11951162B2 (en) | 2018-04-18 | 2024-04-09 | Sk Bioscience Co., Ltd. | Streptococcus pneumoniae capsular polysaccharides and immunogenic conjugate thereof |
TWI788610B (zh) | 2018-12-19 | 2023-01-01 | 美商默沙東有限責任公司 | 包含肺炎鏈球菌多醣-蛋白質結合物之組合物及其使用方法 |
EP4398933A1 (en) | 2021-09-09 | 2024-07-17 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
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US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
US4902506A (en) | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
CA2059693C (en) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
IL101715A (en) | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
JPH07507854A (ja) | 1991-12-23 | 1995-08-31 | ツォッヒェ,ミヒャエル | 油除去装置を備えたエンジン |
EP0616034B1 (en) | 1993-03-05 | 2004-10-20 | Wyeth Holdings Corporation | Plasmid for production of CRM protein and diphtheria toxin |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6113913A (en) | 1998-06-26 | 2000-09-05 | Genvec, Inc. | Recombinant adenovirus |
JP4673974B2 (ja) | 1998-09-30 | 2011-04-20 | ワイス・ホールディングズ・コーポレイション | アジュバントとしての変異コレラホロトキシン |
GB9906437D0 (en) * | 1999-03-19 | 1999-05-12 | Smithkline Beecham Biolog | Vaccine |
EP1880735A3 (en) * | 1999-03-19 | 2008-03-12 | GlaxoSmithKline Biologicals S.A. | Vaccine |
CA2783274C (en) * | 2000-06-29 | 2018-08-07 | Glaxosmithkline Biologicals S.A. | Multivalent vaccine composition with reduced dose of haemophilus influenza type b |
GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
ATE501161T1 (de) | 2000-12-28 | 2011-03-15 | Wyeth Llc | Rekombinantes schutzprotein aus streptococcus pneumoniae |
EP2261241A1 (en) | 2001-04-16 | 2010-12-15 | Wyeth Holdings Corporation | Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof |
WO2002098369A2 (en) | 2001-06-07 | 2002-12-12 | Wyeth Holdings Corporation | Mutant forms of cholera holotoxin as an adjuvant |
JP2004535187A (ja) | 2001-06-07 | 2004-11-25 | ワイス・ホールデイングス・コーポレーシヨン | アジュバントとしてのコレラホロトキシンの突然変異形 |
US20060251675A1 (en) | 2003-03-17 | 2006-11-09 | Michael Hagen | Mutant cholera holotoxin as an adjuvant and an antigen carrier protein |
ME01334B (me) * | 2005-04-08 | 2013-12-20 | Wyeth Llc | Polivalentni pripravak konjugata pneumokoknog polisaharida s proteinom |
AR058592A1 (es) * | 2005-12-22 | 2008-02-13 | Glaxosmithkline Biolog Sa | Vacuna |
US8808707B1 (en) * | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
CN101883583B (zh) * | 2007-06-26 | 2017-05-17 | 葛兰素史密丝克莱恩生物有限公司 | 含有肺炎链球菌荚膜多糖缀合物的疫苗 |
RU2536248C2 (ru) * | 2009-04-30 | 2014-12-20 | Коули Фармасьютикал Груп, Инк. | Пневмококковая вакцина и ее применения |
TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
-
2012
- 2012-12-11 KR KR1020120143318A patent/KR20140075201A/ko not_active IP Right Cessation
-
2013
- 2013-12-05 CA CA2894532A patent/CA2894532C/en active Active
- 2013-12-05 ES ES13862871T patent/ES2881541T3/es active Active
- 2013-12-05 RU RU2015121771A patent/RU2613148C2/ru active
- 2013-12-05 DK DK13862871.4T patent/DK2932980T3/da active
- 2013-12-05 EP EP13862871.4A patent/EP2932980B1/en active Active
- 2013-12-05 JP JP2015547845A patent/JP2016503016A/ja active Pending
- 2013-12-05 WO PCT/KR2013/011195 patent/WO2014092378A1/ko active Application Filing
- 2013-12-05 MX MX2015007301A patent/MX366762B/es active IP Right Grant
- 2013-12-05 PL PL13862871T patent/PL2932980T3/pl unknown
- 2013-12-05 BR BR112015013513-7A patent/BR112015013513B1/pt active IP Right Grant
- 2013-12-05 US US14/651,046 patent/US20150343076A1/en not_active Abandoned
- 2013-12-05 PT PT138628714T patent/PT2932980T/pt unknown
- 2013-12-05 CN CN201380064973.5A patent/CN104837504A/zh active Pending
-
2015
- 2015-06-04 PH PH12015501270A patent/PH12015501270A1/en unknown
- 2015-07-06 CO CO15154485A patent/CO7461130A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR112015013513A2 (pt) | 2017-07-11 |
WO2014092378A1 (ko) | 2014-06-19 |
AU2013360597A1 (en) | 2015-07-02 |
CN104837504A (zh) | 2015-08-12 |
RU2015121771A (ru) | 2017-01-19 |
BR112015013513A8 (pt) | 2018-07-31 |
CA2894532A1 (en) | 2014-06-19 |
KR20140075201A (ko) | 2014-06-19 |
PT2932980T (pt) | 2021-07-29 |
JP2016503016A (ja) | 2016-02-01 |
ES2881541T3 (es) | 2021-11-29 |
BR112015013513B1 (pt) | 2023-02-07 |
CO7461130A2 (es) | 2015-11-30 |
EP2932980B1 (en) | 2021-06-30 |
US20150343076A1 (en) | 2015-12-03 |
PH12015501270A1 (en) | 2015-08-24 |
EP2932980A1 (en) | 2015-10-21 |
EP2932980A4 (en) | 2016-07-06 |
PL2932980T3 (pl) | 2021-11-08 |
MX2015007301A (es) | 2016-01-20 |
CA2894532C (en) | 2020-07-07 |
DK2932980T3 (da) | 2021-07-19 |
RU2613148C2 (ru) | 2017-03-15 |
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