MX365906B - Proceso no mecánico para la micronización de digoxina. - Google Patents
Proceso no mecánico para la micronización de digoxina.Info
- Publication number
- MX365906B MX365906B MX2018001010A MX2018001010A MX365906B MX 365906 B MX365906 B MX 365906B MX 2018001010 A MX2018001010 A MX 2018001010A MX 2018001010 A MX2018001010 A MX 2018001010A MX 365906 B MX365906 B MX 365906B
- Authority
- MX
- Mexico
- Prior art keywords
- digoxin
- micronization
- solution
- concentrated
- purified
- Prior art date
Links
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 title abstract 6
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 title abstract 6
- 229960005156 digoxin Drugs 0.000 title abstract 6
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 title abstract 6
- 238000010297 mechanical methods and process Methods 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- 238000011282 treatment Methods 0.000 abstract 2
- 239000007857 degradation product Substances 0.000 abstract 1
- 230000005226 mechanical processes and functions Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15178009.5A EP3120839B1 (en) | 2015-07-23 | 2015-07-23 | Non-mechanical process for the micronization of digoxin |
| PCT/IB2016/001035 WO2017013485A1 (en) | 2015-07-23 | 2016-07-21 | Non-mechanical process for the micronization of digoxin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018001010A MX2018001010A (es) | 2018-05-17 |
| MX365906B true MX365906B (es) | 2019-06-18 |
Family
ID=54010825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018001010A MX365906B (es) | 2015-07-23 | 2016-07-21 | Proceso no mecánico para la micronización de digoxina. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20180207099A1 (enExample) |
| EP (2) | EP3120839B1 (enExample) |
| JP (1) | JP6814522B2 (enExample) |
| KR (1) | KR20180032587A (enExample) |
| CN (1) | CN108024963A (enExample) |
| AU (1) | AU2016296162B2 (enExample) |
| ES (2) | ES2716681T3 (enExample) |
| HU (2) | HUE042420T2 (enExample) |
| MX (1) | MX365906B (enExample) |
| PL (2) | PL3120839T3 (enExample) |
| PT (2) | PT3120839T (enExample) |
| WO (1) | WO2017013485A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111110632B (zh) * | 2018-10-31 | 2023-01-20 | 上海上药信谊药厂有限公司 | 一种地高辛气雾剂及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3643760A1 (de) * | 1986-12-20 | 1988-06-23 | Boehringer Mannheim Gmbh | Verfahren zur anreicherung und/oder isolierung von herzglykosiden unter verwendung unpolarer adsorberharze |
| WO2003007968A1 (en) | 2001-07-17 | 2003-01-30 | Sun Pharmaceutical Industries Ltd. | A cardiotonic composition |
| CN101390838A (zh) * | 2008-10-10 | 2009-03-25 | 北京工业大学 | 一种制备微粉化药物的方法 |
-
2015
- 2015-07-23 EP EP15178009.5A patent/EP3120839B1/en active Active
- 2015-07-23 ES ES15178009T patent/ES2716681T3/es active Active
- 2015-07-23 HU HUE15178009A patent/HUE042420T2/hu unknown
- 2015-07-23 PT PT15178009T patent/PT3120839T/pt unknown
- 2015-07-23 PL PL15178009T patent/PL3120839T3/pl unknown
-
2016
- 2016-07-21 AU AU2016296162A patent/AU2016296162B2/en not_active Ceased
- 2016-07-21 JP JP2018503128A patent/JP6814522B2/ja not_active Expired - Fee Related
- 2016-07-21 ES ES16754316T patent/ES2765675T3/es active Active
- 2016-07-21 HU HUE16754316A patent/HUE048065T2/hu unknown
- 2016-07-21 US US15/746,697 patent/US20180207099A1/en not_active Abandoned
- 2016-07-21 CN CN201680042406.3A patent/CN108024963A/zh active Pending
- 2016-07-21 KR KR1020187003325A patent/KR20180032587A/ko not_active Ceased
- 2016-07-21 PT PT167543164T patent/PT3324942T/pt unknown
- 2016-07-21 EP EP16754316.4A patent/EP3324942B1/en active Active
- 2016-07-21 WO PCT/IB2016/001035 patent/WO2017013485A1/en not_active Ceased
- 2016-07-21 MX MX2018001010A patent/MX365906B/es active IP Right Grant
- 2016-07-21 PL PL16754316T patent/PL3324942T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2018001010A (es) | 2018-05-17 |
| CN108024963A (zh) | 2018-05-11 |
| AU2016296162A1 (en) | 2018-02-01 |
| PL3120839T3 (pl) | 2019-08-30 |
| JP2018521073A (ja) | 2018-08-02 |
| HUE042420T2 (hu) | 2019-07-29 |
| PT3120839T (pt) | 2019-03-25 |
| BR112018001204A2 (pt) | 2018-09-11 |
| HUE048065T2 (hu) | 2020-05-28 |
| JP6814522B2 (ja) | 2021-01-20 |
| PL3324942T3 (pl) | 2020-05-18 |
| ES2765675T3 (es) | 2020-06-10 |
| US20180207099A1 (en) | 2018-07-26 |
| PT3324942T (pt) | 2020-01-17 |
| EP3120839B1 (en) | 2018-12-19 |
| EP3324942A1 (en) | 2018-05-30 |
| AU2016296162B2 (en) | 2021-03-18 |
| KR20180032587A (ko) | 2018-03-30 |
| WO2017013485A1 (en) | 2017-01-26 |
| EP3120839A1 (en) | 2017-01-25 |
| EP3324942B1 (en) | 2019-10-30 |
| ES2716681T3 (es) | 2019-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |