MX360801B - Formas solidas de moduladores selectivos de receptor de androgenos. - Google Patents

Formas solidas de moduladores selectivos de receptor de androgenos.

Info

Publication number
MX360801B
MX360801B MX2017007289A MX2017007289A MX360801B MX 360801 B MX360801 B MX 360801B MX 2017007289 A MX2017007289 A MX 2017007289A MX 2017007289 A MX2017007289 A MX 2017007289A MX 360801 B MX360801 B MX 360801B
Authority
MX
Mexico
Prior art keywords
solid forms
androgen receptor
receptor modulators
selective androgen
selective
Prior art date
Application number
MX2017007289A
Other languages
English (en)
Inventor
T Dalton James
Ahn Tai
Dickason Dave
Soo Hong Seoung-
G Bird Thomas
Original Assignee
Gtx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gtx Inc filed Critical Gtx Inc
Publication of MX360801B publication Critical patent/MX360801B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a uso de la forma cristalina D de (R) o (S)-N-(4-ciano-3-(trifluorometil)fenil)-3-(4-cianofenoxi) -2-hidroxi-2-metilpropanamida, en la preparación de un medicamento para tratar una condición relacionada con hormonas seleccionada de la disminución de andrógenos en el hombre adulto (ADAM), disminución de andrógenos en las mujeres (ADIF), desgaste muscular crónico y cáncer de próstata.
MX2017007289A 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos. MX360801B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96001207P 2007-09-11 2007-09-11
PCT/US2008/076066 WO2009036206A1 (en) 2007-09-11 2008-09-11 Solid forms of selective androgen receptor modulators

Publications (1)

Publication Number Publication Date
MX360801B true MX360801B (es) 2018-11-16

Family

ID=40452483

Family Applications (6)

Application Number Title Priority Date Filing Date
MX2010002784A MX2010002784A (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos del receptor de androgenos.
MX2017007289A MX360801B (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos.
MX2016010097A MX351941B (es) 2007-09-11 2008-09-11 Formas sólidas de moduladores selectivos de receptor de andrógenos.
MX2012013650A MX341090B (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos.
MX2012013653A MX336760B (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos.
MX2018014065A MX2018014065A (es) 2007-09-11 2010-03-11 Formas solidas de moduladores selectivos de receptor de androgenos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2010002784A MX2010002784A (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos del receptor de androgenos.

Family Applications After (4)

Application Number Title Priority Date Filing Date
MX2016010097A MX351941B (es) 2007-09-11 2008-09-11 Formas sólidas de moduladores selectivos de receptor de andrógenos.
MX2012013650A MX341090B (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos.
MX2012013653A MX336760B (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos.
MX2018014065A MX2018014065A (es) 2007-09-11 2010-03-11 Formas solidas de moduladores selectivos de receptor de androgenos.

Country Status (20)

Country Link
US (1) US7977386B2 (es)
EP (2) EP2871177B1 (es)
JP (3) JP5452492B2 (es)
KR (3) KR20170001736A (es)
CN (3) CN103073450B (es)
AU (1) AU2008298901C1 (es)
CA (3) CA2886501C (es)
CY (1) CY1120107T1 (es)
DK (1) DK2205552T3 (es)
EA (1) EA018611B1 (es)
ES (1) ES2665007T3 (es)
HR (1) HRP20180500T1 (es)
HU (1) HUE036762T2 (es)
IL (2) IL204352A (es)
LT (1) LT2205552T (es)
MX (6) MX2010002784A (es)
NO (1) NO2205552T3 (es)
PL (1) PL2205552T3 (es)
PT (1) PT2205552T (es)
WO (1) WO2009036206A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7919647B2 (en) 2000-08-24 2011-04-05 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7855229B2 (en) * 2000-08-24 2010-12-21 University Of Tennessee Research Foundation Treating wasting disorders with selective androgen receptor modulators
US8853266B2 (en) * 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US20070161608A1 (en) * 2001-12-06 2007-07-12 Dalton James T Selective androgen receptor modulators for treating muscle wasting
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US20110237664A1 (en) * 2004-06-07 2011-09-29 Dalton James T Selective androgen receptor modulators for treating diabetes
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US7968603B2 (en) * 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
CN103073450B (zh) * 2007-09-11 2014-12-03 Gtx公司 选择性雄激素受体调节剂的固体形态
EP2523556A4 (en) * 2010-01-11 2013-08-28 Gtx Inc METHOD FOR TREATING MIBROMED DYNAMIC FUNCTION
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
PT2872482T (pt) 2012-07-13 2020-09-22 Oncternal Therapeutics Inc Método de tratamento de cancro de mama com modulador seletivo do recetor de andrógeno (sarm)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CN110563607B (zh) * 2019-10-25 2022-07-08 许昌远志生物科技有限公司 一种mk-2866的精制方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050038110A1 (en) 2000-08-24 2005-02-17 Steiner Mitchell S. Selective androgen receptor modulators and methods of use thereof
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7026500B2 (en) * 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US7919647B2 (en) 2000-08-24 2011-04-05 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US20070173546A1 (en) * 2000-08-24 2007-07-26 Dalton James T Selective androgen receptor modulators and method of use thereof
US7645898B2 (en) * 2000-08-24 2010-01-12 University Of Tennessee Research Foundation Selective androgen receptor modulators and method of use thereof
JP2004518617A (ja) * 2000-08-24 2004-06-24 ザ・ユニバーシティ・オブ・テネシー・リサーチ・コーポレーション 選択的アンドロゲン受容体モジュレーター及びその使用方法
US7855229B2 (en) 2000-08-24 2010-12-21 University Of Tennessee Research Foundation Treating wasting disorders with selective androgen receptor modulators
IL155041A0 (en) * 2000-09-21 2003-10-31 Bristol Myers Squibb Co Process for the preparation of n-(substituted phenyl)-3-alkyl-, aryl-and heteroarylsulfonyl-2-hydroxy-2-alkyl-and haloalkylpropanamide compounds
ATE526959T1 (de) * 2001-12-06 2011-10-15 Gtx Inc Behandlung von muskelschwund mit selektiven androgenrezeptormodulatoren
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US20070161608A1 (en) * 2001-12-06 2007-07-12 Dalton James T Selective androgen receptor modulators for treating muscle wasting
ES2528764T3 (es) * 2002-02-28 2015-02-12 University Of Tennessee Research Foundation Moduladores selectivos multisustituidos del receptor de andrógeno y métodos de uso de los mismos
CA2502209A1 (en) * 2002-10-15 2004-04-29 University Of Tennessee Research Foundation Methylene-bridged selective androgen receptor modulators and methods of use thereof
CN1826313B (zh) * 2003-01-13 2010-12-08 Gtx公司 选择性雄激素受体调节剂的大规模合成
AU2004281708B2 (en) 2003-10-14 2011-02-17 University Of Tennessee Research Foundation Treating bone-related disorders with selective androgen receptor modulators
EP2425715B1 (en) 2005-08-31 2014-03-05 University of Tennessee Research Foundation Treating symptoms of renal disease with selective androgen receptor modulators (SARM)
TW200730505A (en) 2005-12-07 2007-08-16 Merck & Co Inc Polymorphs of an androgen receptor modulator
CN1825959A (zh) * 2006-03-02 2006-08-30 复旦大学 一种基于自适应多步搜索的图像跟踪算法
CN103073450B (zh) * 2007-09-11 2014-12-03 Gtx公司 选择性雄激素受体调节剂的固体形态
US7968603B2 (en) * 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators

Also Published As

Publication number Publication date
CN101855198B (zh) 2013-07-10
US7977386B2 (en) 2011-07-12
EP2205552A4 (en) 2012-04-18
CA2886498C (en) 2017-09-26
MX2010002784A (es) 2011-06-01
CA2886498A1 (en) 2009-03-19
CN103073450A (zh) 2013-05-01
DK2205552T3 (en) 2018-04-16
JP5599380B2 (ja) 2014-10-01
HUE036762T2 (hu) 2018-07-30
JP5727636B2 (ja) 2015-06-03
JP5452492B2 (ja) 2014-03-26
NO2205552T3 (es) 2018-07-28
PL2205552T3 (pl) 2018-07-31
US20090088480A1 (en) 2009-04-02
KR20160003335A (ko) 2016-01-08
CA2886501C (en) 2018-03-27
PT2205552T (pt) 2018-04-24
HRP20180500T1 (hr) 2018-06-01
JP2014133744A (ja) 2014-07-24
CA2886501A1 (en) 2009-03-19
KR20170001736A (ko) 2017-01-04
EP2871177A1 (en) 2015-05-13
EP2205552A1 (en) 2010-07-14
CN103553966A (zh) 2014-02-05
ES2665007T3 (es) 2018-04-24
JP2010539181A (ja) 2010-12-16
CA2709118A1 (en) 2009-03-19
EA018611B1 (ru) 2013-09-30
LT2205552T (lt) 2018-04-10
IL251483A0 (en) 2017-05-29
CN103073450B (zh) 2014-12-03
MX336760B (es) 2016-01-29
CY1120107T1 (el) 2018-12-12
CA2709118C (en) 2018-03-13
AU2008298901A1 (en) 2009-03-19
EP2205552B1 (en) 2018-02-28
CN101855198A (zh) 2010-10-06
MX2018014065A (es) 2020-09-02
KR101580905B1 (ko) 2015-12-29
MX351941B (es) 2017-11-03
CN103553966B (zh) 2016-09-07
MX341090B (es) 2016-08-08
JP2012067118A (ja) 2012-04-05
KR101691877B1 (ko) 2017-01-02
EA201070350A1 (ru) 2010-12-30
KR20100090239A (ko) 2010-08-13
WO2009036206A1 (en) 2009-03-19
IL204352A (en) 2013-10-31
EP2871177B1 (en) 2019-07-17
AU2008298901B2 (en) 2013-05-09
AU2008298901C1 (en) 2013-10-03

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