MX358980B - Colocacion optimizada de canula para suministro de terapeuticos al cerebro. - Google Patents
Colocacion optimizada de canula para suministro de terapeuticos al cerebro.Info
- Publication number
- MX358980B MX358980B MX2012002423A MX2012002423A MX358980B MX 358980 B MX358980 B MX 358980B MX 2012002423 A MX2012002423 A MX 2012002423A MX 2012002423 A MX2012002423 A MX 2012002423A MX 358980 B MX358980 B MX 358980B
- Authority
- MX
- Mexico
- Prior art keywords
- brain
- delivery
- cannula
- therapeutics
- placement
- Prior art date
Links
- 210000004556 brain Anatomy 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
- A61B5/4064—Evaluating the brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
- A61B90/11—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
- A61B2034/101—Computer-aided simulation of surgical operations
- A61B2034/105—Modelling of the patient, e.g. for ligaments or bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/374—NMR or MRI
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Physiology (AREA)
- Chemical & Material Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychology (AREA)
- Genetics & Genomics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Primary Health Care (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporcionan métodos y sistemas para el suministro mejorado de agentes a las regiones seleccionadas del cerebro, por el uso de las coordenadas de colocación que proporcionan la colocación óptima de la cánula de suministro. Optimizando la colocación de cánula, se alcanza la distribución reproducible de la infusión en la región seleccionada del cerebro, permitiendo un suministro más efectivo de los terapéuticos al cerebro.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27520909P | 2009-08-25 | 2009-08-25 | |
PCT/US2010/046680 WO2011025836A1 (en) | 2009-08-25 | 2010-08-25 | Optimized placement of cannula for delivery of therapeutics to the brain |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012002423A MX2012002423A (es) | 2012-09-07 |
MX358980B true MX358980B (es) | 2018-09-11 |
Family
ID=43628370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012002423A MX358980B (es) | 2009-08-25 | 2010-08-25 | Colocacion optimizada de canula para suministro de terapeuticos al cerebro. |
Country Status (11)
Country | Link |
---|---|
US (2) | US20120209110A1 (es) |
EP (1) | EP2470250A4 (es) |
JP (1) | JP5847717B2 (es) |
KR (1) | KR101649145B1 (es) |
CN (1) | CN102573979B (es) |
AU (1) | AU2010286668B2 (es) |
BR (1) | BR112012004166A8 (es) |
CA (1) | CA2771175C (es) |
CL (1) | CL2012000435A1 (es) |
MX (1) | MX358980B (es) |
WO (1) | WO2011025836A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
ES2854832T3 (es) * | 2011-08-01 | 2021-09-23 | Alcyone Lifesciences Inc | Dispositivos microfluídicos de administración de medicamentos |
EP2810197B1 (en) * | 2012-02-02 | 2018-04-04 | Brainlab AG | Method for determining an infusion parameter |
US9020224B2 (en) | 2012-04-27 | 2015-04-28 | Medtronic, Inc. | Volume of efficacy model capture |
US9393361B2 (en) | 2012-12-14 | 2016-07-19 | Medtronic, Inc. | Method to determine a material distribution |
US9008752B2 (en) | 2012-12-14 | 2015-04-14 | Medtronic, Inc. | Method to determine distribution of a material by an infused magnetic resonance image contrast agent |
ES2869328T3 (es) | 2012-12-18 | 2021-10-25 | Alcyone Lifesciences Inc | Dispositivos y métodos para reducir o evitar un reflujo en un sistema de administración |
US20140255471A1 (en) | 2013-03-11 | 2014-09-11 | Wake Forest University Health Sciences | Method of treating brain tumors |
PL2970492T3 (pl) | 2013-03-15 | 2019-10-31 | Univ Wake Forest Health Sciences | Przeciwciała przeciwko ludzkim i psim il-13ra2 |
WO2014171826A1 (en) | 2013-04-17 | 2014-10-23 | Stichting Vu-Vumc | Treatment of cognitive impairment in depressive disorders |
EP2991560B1 (en) | 2013-04-30 | 2020-07-29 | Cedars-Sinai Medical Center | Stabilization apparatuses for medical procedures |
GB201308917D0 (en) * | 2013-05-17 | 2013-07-03 | Renishaw Plc | Delivery |
CA3120114A1 (en) | 2013-06-17 | 2014-12-24 | Alcyone Lifesciences, Inc. | Methods and devices for protecting catheter tips and stereotactic fixtures for microcatheters |
ES2738298T3 (es) | 2013-07-31 | 2020-01-21 | Alcyone Lifesciences Inc | Sistemas y métodos de suministro de fármacos, tratamiento y monitoreo |
WO2015067299A1 (en) * | 2013-11-05 | 2015-05-14 | Brainlab Ag | Quantification of brain vulnerability |
WO2015070210A1 (en) | 2013-11-11 | 2015-05-14 | Wake Forest University Health Sciences | Epha3 and multi-valent targeting of tumors |
EP3209311B1 (en) | 2014-10-21 | 2024-03-06 | University of Massachusetts | Recombinant aav variants and uses thereof |
CN107106814B (zh) | 2014-10-29 | 2021-02-26 | 西达-赛奈医疗中心 | 一种用于治疗剂和相关物质的受控输送的设备、系统和方法 |
WO2016077607A1 (en) | 2014-11-13 | 2016-05-19 | The Regents Of The University Of California | Adjustable stepped cannula |
US10806396B2 (en) * | 2015-01-26 | 2020-10-20 | Alcyone Lifesciences, Inc. | Drug delivery methods with tracer |
WO2016163886A2 (en) | 2015-04-10 | 2016-10-13 | Clues2Cure International B.V. | Administration of taurine or an analog thereof for the treatment of nerve cell damage |
JP2018535004A (ja) * | 2015-10-30 | 2018-11-29 | シーダーズ−サイナイ メディカル センター | 組織リトラクタシステム及び方法 |
CA3008680A1 (en) | 2016-01-04 | 2017-07-13 | Alcyone Lifesciences, Inc. | Methods and devices for treating stroke |
EP3506817A4 (en) | 2016-08-30 | 2020-07-22 | The Regents of The University of California | METHOD FOR BIOMEDICAL TARGETING AND RELEASE, AND DEVICES AND SYSTEMS FOR IMPLEMENTING THEM |
AU2017341849B2 (en) | 2016-10-13 | 2024-03-21 | University Of Massachusetts | AAV capsid designs |
WO2018111099A1 (en) | 2016-12-12 | 2018-06-21 | Stichting Vumc | Biomarkers and treatments for cerebral amyloid angiopathy (caa) |
JP7229989B2 (ja) | 2017-07-17 | 2023-02-28 | ボイジャー セラピューティクス インコーポレイテッド | 軌道アレイガイドシステム |
CN108186133B (zh) * | 2017-12-05 | 2020-12-01 | 广东省实验动物监测所 | 非人灵长类动物脑黑质区的定位方法 |
US11550012B2 (en) * | 2018-06-11 | 2023-01-10 | Canon Medical Systems Corporation | Magnetic resonance imaging apparatus and imaging processing method for determining a region to which processing is to be performed |
AU2019359377A1 (en) * | 2018-10-10 | 2021-05-20 | The Research Foundation For Mental Hygiene, Inc. | System, method and computer-accessible medium for neuromelanin-sensitive magnetic resonance imaging as a non-invasive proxy measure of dopamine function in the human brain |
WO2021102422A1 (en) * | 2019-11-22 | 2021-05-27 | The Brigham And Women's Hospital, Inc. | Systems and methods for ventricle procedures |
US12079960B2 (en) | 2021-03-11 | 2024-09-03 | Terran Biosciences Inc. | Systems, devices, and methods for harmonization of imaging datasets including biomarkers |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7505807B1 (en) * | 1997-05-15 | 2009-03-17 | Regents Of The University Of Minnesota | Magnetic resonance apparatus for use with active electrode and drug deliver catheter |
ES2324540T3 (es) * | 1998-05-27 | 2009-08-10 | Genzyme Corporation | Vectores aav para la fabricacion de medicamentos para la administracion potenciada por conveccion. |
US20040092879A1 (en) * | 2000-11-06 | 2004-05-13 | Medamicus, Inc. | Safety introducer apparatus and method therefor |
WO2003004660A1 (en) * | 2001-07-03 | 2003-01-16 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods of administering vectors to synaptically connected neurons |
GB0205773D0 (en) * | 2002-03-12 | 2002-04-24 | Gill Steven S | Clamp |
AU2003299140B2 (en) * | 2002-09-24 | 2008-07-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for convection enhanced delivery of therapeutic agents |
EP1786320B1 (en) * | 2004-07-27 | 2016-09-14 | MRI Interventions, Inc. | Mri systems having mri compatible universal delivery cannulas with cooperating mri antenna probes and related systems and methods |
US8391959B2 (en) * | 2004-09-29 | 2013-03-05 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Composition for improving efficiency of drug delivery |
CN101123919A (zh) * | 2004-10-05 | 2008-02-13 | 建新公司 | 台阶式插管 |
AU2006283189B2 (en) * | 2005-08-23 | 2013-01-31 | The Regents Of The University Of California | Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery |
EP1788498A1 (en) * | 2005-11-21 | 2007-05-23 | BrainLAB AG | Apparatus for infusing substances |
WO2007127839A2 (en) * | 2006-04-26 | 2007-11-08 | The Regents Of The University Of California | Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics |
US8150498B2 (en) * | 2006-09-08 | 2012-04-03 | Medtronic, Inc. | System for identification of anatomical landmarks |
DE602008003941D1 (de) * | 2007-04-13 | 2011-01-27 | Brainlab Ag | Verfahren und Vorrichtung für die Planung lokaler Verabreichung eines Arzneimittels |
CA2701744A1 (en) * | 2007-10-08 | 2009-04-16 | Renishaw (Ireland) Limited | Catheter |
-
2010
- 2010-08-25 EP EP10812591.5A patent/EP2470250A4/en not_active Withdrawn
- 2010-08-25 AU AU2010286668A patent/AU2010286668B2/en not_active Ceased
- 2010-08-25 CA CA2771175A patent/CA2771175C/en not_active Expired - Fee Related
- 2010-08-25 MX MX2012002423A patent/MX358980B/es active IP Right Grant
- 2010-08-25 WO PCT/US2010/046680 patent/WO2011025836A1/en active Application Filing
- 2010-08-25 CN CN201080046521.0A patent/CN102573979B/zh not_active Expired - Fee Related
- 2010-08-25 KR KR1020127006564A patent/KR101649145B1/ko active IP Right Grant
- 2010-08-25 JP JP2012526947A patent/JP5847717B2/ja not_active Expired - Fee Related
- 2010-08-25 US US13/391,606 patent/US20120209110A1/en not_active Abandoned
- 2010-08-25 BR BR112012004166A patent/BR112012004166A8/pt active Search and Examination
-
2012
- 2012-02-20 CL CL2012000435A patent/CL2012000435A1/es unknown
-
2018
- 2018-07-26 US US16/046,352 patent/US20180344199A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2011025836A1 (en) | 2011-03-03 |
KR20120089457A (ko) | 2012-08-10 |
US20180344199A1 (en) | 2018-12-06 |
JP2013502997A (ja) | 2013-01-31 |
MX2012002423A (es) | 2012-09-07 |
CL2012000435A1 (es) | 2012-10-12 |
AU2010286668A1 (en) | 2012-03-08 |
AU2010286668B2 (en) | 2015-04-09 |
EP2470250A1 (en) | 2012-07-04 |
CN102573979A (zh) | 2012-07-11 |
EP2470250A4 (en) | 2013-07-17 |
BR112012004166A8 (pt) | 2016-10-04 |
CN102573979B (zh) | 2016-01-13 |
JP5847717B2 (ja) | 2016-01-27 |
KR101649145B1 (ko) | 2016-08-18 |
US20120209110A1 (en) | 2012-08-16 |
CA2771175A1 (en) | 2011-03-03 |
CA2771175C (en) | 2017-12-05 |
BR112012004166A2 (pt) | 2016-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX358980B (es) | Colocacion optimizada de canula para suministro de terapeuticos al cerebro. | |
MX346439B (es) | Métodos y medios para modificar un genoma vegetal. | |
IN2014CN02887A (es) | ||
AU2011328009A8 (en) | Compounds and methods for treating pain | |
MX345747B (es) | Dispositivo de inyección automático portable. | |
MX356525B (es) | Vectores de virus asociados con adeno (aav) para uso en terapia de genes de coroideremia. | |
MX2014000129A (es) | Combinaciones de farmacos y su usos en el tratamiento de una condicion de tos. | |
MX2013009068A (es) | Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos. | |
MX2013003076A (es) | Terapeuticos contra cancer de mama. | |
MY170934A (en) | Treatment of pain associated with dislocation of basal endometrium | |
MX353964B (es) | Agentes terapeuticos y usos de los mismos. | |
EP2582682A4 (en) | METHOD FOR THE TREATMENT OF LUNG DISEASES | |
WO2010085665A3 (en) | Targeted delivery system | |
MX2015004389A (es) | Metodos y composiciones para tratar esclerosis multiple y trastornos relacionadods. | |
SG10201810575WA (en) | Treatment of prostate cancer with tor kinase inhibitors | |
NZ609594A (en) | Eph receptor expression in tumor stem cells | |
MX2013006319A (es) | Composiciones y metodos para tratar el cancer usando un inhibidor de pi3k y un inhibidor de mek. | |
MD20140004A2 (en) | Deuterated 1-piperazino-3-phenyl-indanes for treatment of schizophrenia | |
MX2011008994A (es) | Metodos de usar sns - 595 para el tratamiento de sujetos con cancer con actividad reducida de brca2. | |
MX354667B (es) | Metodos para el tratamiento de un impedimento sensorial-motriz relacionado con el accidente cerebrovascular con el uso de aminopiridinas. | |
WO2012006585A3 (en) | Use of interleukin-15 to treat cardiovascular diseases | |
MX362111B (es) | Un metodo para mejorar la funcion hepatica. | |
TN2014000418A1 (en) | Methods for treating cancer using pi3k inhibitor and mek inhibitor | |
UA58066U (ru) | Способ лечения генитальной вирусной инфекции | |
UA38340U (ru) | Способ лечения женщин с патологическим прелиминарным периодом |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |