MX356050B - Composicion farmaceutica acuosa con estabilidad mejorada. - Google Patents
Composicion farmaceutica acuosa con estabilidad mejorada.Info
- Publication number
- MX356050B MX356050B MX2014009573A MX2014009573A MX356050B MX 356050 B MX356050 B MX 356050B MX 2014009573 A MX2014009573 A MX 2014009573A MX 2014009573 A MX2014009573 A MX 2014009573A MX 356050 B MX356050 B MX 356050B
- Authority
- MX
- Mexico
- Prior art keywords
- composition
- pharmaceutical composition
- aqueous pharmaceutical
- enhanced stability
- aqueous
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención es una composición farmacéutica acuosa que incluye un agente terapéutico ionizado, un componente iónico y goma guar. La goma guar está presente en la composición a una concentración suficiente para limitar interacciones entre el agente terapéutico ionizado y el componente iónico altera de esta manera la estabilidad de la composición. Preferiblemente la composición está en o cerca del pH fisiológico. Se ha encontrado que la composición farmacéutica acuosa es particularmente útil como una composición oftálmica, ática o nasal acuosa. La composición farmacéutica, debido a su característica, es particularmente adecuada como una composición oftálmica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261597416P | 2012-02-10 | 2012-02-10 | |
PCT/US2013/025376 WO2013119974A1 (en) | 2012-02-10 | 2013-02-08 | Aqueous pharmaceutical composition with enhanced stability |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014009573A MX2014009573A (es) | 2015-04-08 |
MX356050B true MX356050B (es) | 2018-05-11 |
Family
ID=47750831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014009573A MX356050B (es) | 2012-02-10 | 2013-02-08 | Composicion farmaceutica acuosa con estabilidad mejorada. |
Country Status (12)
Country | Link |
---|---|
US (2) | US20130210812A1 (es) |
EP (1) | EP2811979B1 (es) |
JP (1) | JP6180443B2 (es) |
KR (1) | KR102047954B1 (es) |
CN (1) | CN104168885A (es) |
AU (1) | AU2013216847B2 (es) |
BR (1) | BR112014019742A8 (es) |
CA (1) | CA2864165A1 (es) |
MX (1) | MX356050B (es) |
RU (1) | RU2014136715A (es) |
TW (1) | TW201336527A (es) |
WO (1) | WO2013119974A1 (es) |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4027020A (en) | 1974-10-29 | 1977-05-31 | Millmaster Onyx Corporation | Randomly terminated capped polymers |
US3931319A (en) | 1974-10-29 | 1976-01-06 | Millmaster Onyx Corporation | Capped polymers |
US4525346A (en) | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
US4836986A (en) | 1984-09-28 | 1989-06-06 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
JPS6310784A (ja) | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
US5037647A (en) | 1988-09-15 | 1991-08-06 | Alcon Laboratories, Inc. | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
US5145643A (en) | 1990-01-05 | 1992-09-08 | Allergan, Inc. | Nonoxidative ophthalmic compositions and methods for preserving and using same |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
US5300287A (en) | 1992-11-04 | 1994-04-05 | Alcon Laboratories, Inc. | Polymeric antimicrobials and their use in pharmaceutical compositions |
GB9711643D0 (en) * | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
DE69834154T2 (de) | 1997-07-01 | 2007-01-25 | Pfizer Products Inc., Groton | Verfahren zur Herstellung von einem Cyclodextrin |
US6403609B1 (en) * | 1997-07-29 | 2002-06-11 | Alcon Manufacturing, Ltd. | Ophthalmic compositions containing galactomannan polymers and borate |
WO2001054687A1 (en) * | 2000-01-25 | 2001-08-02 | Alcon Universal Ltd. | Ophthalmic anti-allergy compositions suitable for use with contact lenses |
AU2003213210A1 (en) * | 2002-02-22 | 2003-09-09 | Pharmacia Corporation | Ophthalmic formulation with gum system |
WO2004069157A2 (en) * | 2003-01-17 | 2004-08-19 | Ophthalmic Research Associates, Inc. | Combinational use of long-acting and short-acting anti-histamines for ocular allergies |
WO2008015695A2 (en) * | 2006-05-15 | 2008-02-07 | Sun Pharmaceutical Industries Limited | Inclusion complex of olopatadine and cyclodextrin |
TWI434926B (zh) | 2006-12-11 | 2014-04-21 | Alcon Res Ltd | 眼用組成物中聚氧化乙烯-聚氧化丁烯(peo-pbo)嵌段共聚物之使用 |
DK2114367T3 (en) * | 2007-02-07 | 2015-12-07 | Novartis Ag | Olopatadine formulations for topical nasal administration |
WO2008100807A2 (en) * | 2007-02-09 | 2008-08-21 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of three polymers |
TW200904485A (en) * | 2007-05-18 | 2009-02-01 | Alcon Res Ltd | Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions |
US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
BRPI1008654A2 (pt) | 2009-02-05 | 2016-03-08 | Alcon Res Ltd | processo para purificação de guar |
TWI478730B (zh) * | 2009-12-03 | 2015-04-01 | Alcon Res Ltd | 眼科乳劑 |
HUE025838T2 (en) * | 2009-12-03 | 2016-04-28 | Alcon Res Ltd | Nanoparticulate suspensions containing carboxyvinyl polymer |
AU2011248129B2 (en) * | 2010-05-05 | 2014-10-09 | Alcon Inc. | Stabilized ophthalmic galactomannan formulations |
WO2011141929A2 (en) * | 2010-05-11 | 2011-11-17 | Cadila Healthcare Limited | Aqueous pharmaceutical compositions of fluticasone and olopatadine |
TWI544922B (zh) * | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠(olopatadine)眼用組成物 |
-
2013
- 2013-02-04 TW TW102104183A patent/TW201336527A/zh unknown
- 2013-02-08 EP EP13706360.8A patent/EP2811979B1/en not_active Not-in-force
- 2013-02-08 AU AU2013216847A patent/AU2013216847B2/en not_active Ceased
- 2013-02-08 WO PCT/US2013/025376 patent/WO2013119974A1/en active Application Filing
- 2013-02-08 US US13/763,023 patent/US20130210812A1/en not_active Abandoned
- 2013-02-08 KR KR1020147024529A patent/KR102047954B1/ko active IP Right Grant
- 2013-02-08 RU RU2014136715A patent/RU2014136715A/ru not_active Application Discontinuation
- 2013-02-08 CA CA2864165A patent/CA2864165A1/en not_active Abandoned
- 2013-02-08 JP JP2014556735A patent/JP6180443B2/ja not_active Expired - Fee Related
- 2013-02-08 MX MX2014009573A patent/MX356050B/es active IP Right Grant
- 2013-02-08 CN CN201380014179.XA patent/CN104168885A/zh active Pending
- 2013-02-08 BR BR112014019742A patent/BR112014019742A8/pt not_active IP Right Cessation
-
2014
- 2014-08-25 US US14/468,243 patent/US20140364422A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR112014019742A8 (pt) | 2017-07-11 |
KR20140120932A (ko) | 2014-10-14 |
RU2014136715A (ru) | 2016-03-27 |
US20130210812A1 (en) | 2013-08-15 |
EP2811979A1 (en) | 2014-12-17 |
TW201336527A (zh) | 2013-09-16 |
BR112014019742A2 (es) | 2017-06-20 |
AU2013216847A1 (en) | 2014-09-04 |
CN104168885A (zh) | 2014-11-26 |
CA2864165A1 (en) | 2013-08-15 |
JP6180443B2 (ja) | 2017-08-16 |
WO2013119974A1 (en) | 2013-08-15 |
US20140364422A1 (en) | 2014-12-11 |
JP2015509933A (ja) | 2015-04-02 |
MX2014009573A (es) | 2015-04-08 |
KR102047954B1 (ko) | 2019-11-22 |
AU2013216847B2 (en) | 2016-06-23 |
EP2811979B1 (en) | 2018-05-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |