MX343671B - Metodos de tratamiento de cancer de vejiga. - Google Patents

Metodos de tratamiento de cancer de vejiga.

Info

Publication number
MX343671B
MX343671B MX2012013909A MX2012013909A MX343671B MX 343671 B MX343671 B MX 343671B MX 2012013909 A MX2012013909 A MX 2012013909A MX 2012013909 A MX2012013909 A MX 2012013909A MX 343671 B MX343671 B MX 343671B
Authority
MX
Mexico
Prior art keywords
bladder cancer
methods
treating bladder
treating
taxane
Prior art date
Application number
MX2012013909A
Other languages
English (en)
Other versions
MX2012013909A (es
Inventor
Patrick Soon-Shiong
Neil P Desai
Original Assignee
Abraxis Bioscience Llc *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45067028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX343671(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abraxis Bioscience Llc * filed Critical Abraxis Bioscience Llc *
Publication of MX2012013909A publication Critical patent/MX2012013909A/es
Publication of MX343671B publication Critical patent/MX343671B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

La presente invención provee métodos y composiciones para tratamiento de cáncer de vejiga, incluyendo cáncer de vejiga metastático y cáncer de vejiga no musculo invasivo al administrar una composición que comprende nanopartículas que comprenden un taxano y una albumina.
MX2012013909A 2010-06-02 2011-05-20 Metodos de tratamiento de cancer de vejiga. MX343671B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39680010P 2010-06-02 2010-06-02
US201161449513P 2011-03-04 2011-03-04
PCT/US2011/037449 WO2011153009A1 (en) 2010-06-02 2011-05-20 Methods of treating bladder cancer

Publications (2)

Publication Number Publication Date
MX2012013909A MX2012013909A (es) 2013-02-21
MX343671B true MX343671B (es) 2016-11-16

Family

ID=45067028

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012013909A MX343671B (es) 2010-06-02 2011-05-20 Metodos de tratamiento de cancer de vejiga.

Country Status (20)

Country Link
US (2) US20130266659A1 (es)
EP (1) EP2575803B1 (es)
JP (1) JP2013527232A (es)
KR (1) KR20130109025A (es)
CN (1) CN103221042B (es)
AU (1) AU2011261684B2 (es)
BR (1) BR112012030699A2 (es)
CA (1) CA2801314A1 (es)
CO (1) CO6620019A2 (es)
CR (1) CR20120619A (es)
ES (1) ES2639038T3 (es)
MX (1) MX343671B (es)
MY (1) MY188911A (es)
NI (1) NI201200175A (es)
NZ (2) NZ708506A (es)
PH (1) PH12016502066A1 (es)
RU (1) RU2621640C2 (es)
SG (1) SG186109A1 (es)
WO (1) WO2011153009A1 (es)
ZA (1) ZA201208815B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
CN104587479A (zh) 2002-12-09 2015-05-06 阿布拉西斯生物科学有限责任公司 组合物和传递药剂的方法
ATE531365T1 (de) 2005-02-18 2011-11-15 Abraxis Bioscience Llc Kombinationen und modi zur verabreichung therapeutischer mittel und kombinationstherapie
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
DK3311805T3 (da) * 2005-08-31 2020-04-14 Abraxis Bioscience Llc Sammensætninger, der omfatter svært vandopløselige farmaceutiske midler og antimikrobielle midler
CA2672618C (en) 2006-12-14 2021-03-02 Abraxis Bioscience, Llc Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane
SI2131821T1 (sl) * 2007-03-07 2018-11-30 Abraxis Bioscience, Llc Nanodelci, ki zajemajo rapamicin in albumin kot sredstvo proti raku
EP2155188B1 (en) 2007-06-01 2013-10-09 Abraxis BioScience, LLC Methods and compositions for treating recurrent cancer
RU2559570C2 (ru) 2009-04-15 2015-08-10 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Композиции без приона на основе наночастиц и способы их получения
AU2011230512B2 (en) 2010-03-26 2016-09-15 Abraxis Bioscience, Llc Methods of treatment of hepatocellular carcinoma
PL2552415T3 (pl) 2010-03-29 2017-03-31 Abraxis Bioscience, Llc Sposoby leczenia nowotworu
CN105147613A (zh) 2010-03-29 2015-12-16 阿布拉科斯生物科学有限公司 增强药物递送和治疗剂有效性的方法
KR102447139B1 (ko) 2010-05-14 2022-09-23 더 제너럴 하스피톨 코포레이션 종양 특이적 신생항원을 확인하는 조성물 및 방법
MY162903A (en) 2010-06-04 2017-07-31 Abraxis Bioscience Llc Methods of treatment of pancreatic cancer
MY166014A (en) * 2010-06-07 2018-05-21 Abraxis Bioscience Llc Combination therapy methods for treating proliferative diseases
KR20200051841A (ko) 2011-04-28 2020-05-13 아브락시스 바이오사이언스, 엘엘씨 나노입자 조성물의 혈관내 전달 및 그의 용도
BR112014014323A2 (pt) 2011-12-14 2017-06-13 Abraxis Bioscience Llc uso de excipientes poliméricos para liofilização ou congelamento de partículas
DK177379B1 (en) * 2012-03-29 2013-02-25 Entomopharm Aps Insect-based model to study the effect and integrity of nanoparticles on blood-brain barrier function
US9149455B2 (en) 2012-11-09 2015-10-06 Abraxis Bioscience, Llc Methods of treating melanoma
US20140199404A1 (en) * 2013-01-11 2014-07-17 Abraxis Bioscience, Llc Method for treating cancer based on level of a nucleoside transporter
US9511046B2 (en) 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
NZ630392A (en) 2013-03-12 2016-10-28 Abraxis Bioscience Llc Methods of treating lung cancer
NZ630367A (en) * 2013-03-13 2017-02-24 Abraxis Bioscience Llc Methods of treatment of pediatric solid tumor
JP6309610B2 (ja) 2013-03-14 2018-04-11 アブラクシス バイオサイエンス， エルエルシー 膀胱がんを処置する方法
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
KR20160101073A (ko) 2013-12-20 2016-08-24 더 브로드 인스티튜트, 인코퍼레이티드 신생항원 백신과의 병용 요법
WO2015018380A2 (en) * 2014-07-03 2015-02-12 Cspc Zhongqi Pharmaceutical Technology(Shijiazhuang)Co., Ltd. Therapeutic nanoparticles and the preparation methods thereof
EP3234193B1 (en) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Molecular biomarkers for cancer immunotherapy
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
US10705070B1 (en) 2015-03-05 2020-07-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug
US10527604B1 (en) 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
CN116196401A (zh) 2015-05-20 2023-06-02 博德研究所 共有的新抗原
US11291646B2 (en) 2015-06-04 2022-04-05 Crititech, Inc. Nozzle assembly and methods for use
US20180177771A1 (en) * 2015-06-29 2018-06-28 Abraxis Bioscience, Llc Biomarkers for nanoparticle compositions
DK3313401T3 (da) 2015-06-29 2021-11-15 Abraxis Bioscience Llc Nanopartikler omfattende sirolimus og albumin til anvendelse i behandling af epithelioide celletumorer
EP3328380A4 (en) * 2015-07-31 2019-07-24 Pharmacyclics LLC INHIBITOR COMBINATIONS OF BRUTON TYROSINE KINASE AND USES THEREOF
CA3018989A1 (en) 2016-04-04 2017-10-12 Crititech, Inc. Methods for solid tumor treatment
WO2017193098A1 (en) * 2016-05-06 2017-11-09 Taris Biomedical Llc Method of treating lower tract urothelial cancer
EP3574116A1 (en) 2017-01-24 2019-12-04 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
CA3063420A1 (en) 2017-06-09 2018-12-13 Crititech, Inc. Treatment of epithelial cysts by intracystic injection of antineoplastic particles
SG10201913400QA (en) 2017-06-14 2020-03-30 Crititech Inc Methods for treating lung disorders
BR112020000832A2 (pt) 2017-07-25 2020-07-21 Taris Biomedical Llc métodos para tratar metástase tumoral
JP2020536052A (ja) 2017-10-03 2020-12-10 クリティテック・インコーポレイテッド 癌の治療のための免疫療法剤の全身送達と組み合わせた抗腫瘍粒子の局所送達
CN111787926A (zh) 2017-11-08 2020-10-16 塔里斯生物医药公司 使用吉西他滨对膀胱癌进行治疗和维持疗法的方法
WO2019126186A1 (en) 2017-12-18 2019-06-27 Neon Therapeutics, Inc. Neoantigens and uses thereof
WO2019136187A1 (en) * 2018-01-05 2019-07-11 Crititech, Inc. Treatment of bladder cancer by local administration of taxane particles
KR20200135410A (ko) 2018-03-20 2020-12-02 아브락시스 바이오사이언스, 엘엘씨 mTOR 억제제 및 알부민의 나노입자의 투여를 통한 중추 신경계 장애의 치료 방법
WO2020072090A1 (en) * 2018-10-03 2020-04-09 Crititech, Inc. Use of antineoplastic agents to stimulate the immune system for production of tertiary lymphoid structures (tls)
KR20220106758A (ko) 2019-10-28 2022-07-29 아브락시스 바이오사이언스, 엘엘씨 알부민 및 라파마이신의 제약 조성물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
DK1155689T3 (da) * 1993-07-19 2006-11-20 Angiotech Pharm Inc Antiangiogene stents og fremgangsmåder til fremstilling heraf
GB9811598D0 (en) * 1998-05-30 1998-07-29 Imp College Innovations Ltd Diagnosis and treatment of cancer
RU2361615C2 (ru) * 2002-12-09 2009-07-20 Абраксис Байосайенс, Ллс. Композиции и способы доставки фармакологических агентов
CN104587479A (zh) 2002-12-09 2015-05-06 阿布拉西斯生物科学有限责任公司 组合物和传递药剂的方法
AU2006249235B2 (en) * 2004-05-14 2010-11-11 Abraxis Bioscience, Llc Sparc and methods of use thereof
ATE531365T1 (de) * 2005-02-18 2011-11-15 Abraxis Bioscience Llc Kombinationen und modi zur verabreichung therapeutischer mittel und kombinationstherapie
BRPI0615292A8 (pt) 2005-08-31 2018-03-06 Abraxis Bioscience Llc composições e métodos para preparação de fármacos de má solubilidade em água com estabilidade aumentada
JP5641927B2 (ja) * 2007-04-13 2014-12-17 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー Ｓｐａｒｃ及びその使用方法
CA2686736A1 (en) 2007-05-03 2008-11-13 Abraxis Bioscience, Llc Nanoparticle compositions comprising rapamycin for treating pulmonary hypertension
EP2367425B1 (en) * 2008-12-11 2018-02-28 Abraxis BioScience, LLC Combination therapy including a taxane and a further therapeutic agent
RU2561055C2 (ru) * 2009-08-25 2015-08-20 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Комбинированная терапия композициями наночастиц таксана и ингибиторами хэджхог

Also Published As

Publication number Publication date
RU2012157805A (ru) 2014-07-20
EP2575803A1 (en) 2013-04-10
ZA201208815B (en) 2014-01-29
SG186109A1 (en) 2013-01-30
CN103221042A (zh) 2013-07-24
MX2012013909A (es) 2013-02-21
EP2575803A4 (en) 2014-01-01
BR112012030699A2 (pt) 2016-09-13
NI201200175A (es) 2013-05-13
WO2011153009A1 (en) 2011-12-08
MY188911A (en) 2022-01-13
KR20130109025A (ko) 2013-10-07
PH12016502066A1 (en) 2019-02-04
RU2621640C2 (ru) 2017-06-06
JP2013527232A (ja) 2013-06-27
US20130266659A1 (en) 2013-10-10
EP2575803B1 (en) 2017-07-26
CR20120619A (es) 2014-03-21
CN103221042B (zh) 2016-02-10
NZ708506A (en) 2016-08-26
US20140056986A1 (en) 2014-02-27
AU2011261684B2 (en) 2016-09-15
CA2801314A1 (en) 2011-12-08
NZ604029A (en) 2015-07-31
CO6620019A2 (es) 2013-02-15
AU2011261684A1 (en) 2013-01-10
ES2639038T3 (es) 2017-10-25

Similar Documents

Publication Publication Date Title
PH12016502066A1 (en) Methods of treating bladder cancer
MX2015011753A (es) Metodos para tratar cancer de vegija.
PH12019501393A1 (en) Afucosylated anti-fgfr2iiib antibodies
MX364637B (es) Platino y nanopartículas que incluyen placlitaxel/albúmina para usarse en el trartamiento de nsclc.
MX2015011783A (es) Metodos para tratar tumores solidos pediatricos.
MX346861B (es) Metodos de tratamiento de carcinoma hepato celular.
MX360404B (es) Compuestos para inhibir la proliferacion celular en canceres transmitidos por egfr.
MX2015010312A (es) Metodos para tratamiento del melanoma.
MX2015008889A (es) Metodo para tratar cancer con base en el estado de la mutacion k-ras.
NZ707086A (en) Anti-cd40 antibodies and methods of use
MX2015011752A (es) Metodos para tratar cancer de pulmon.
MX347225B (es) Metodos de tratamiento contra el cancer pancreatico.
TW201611831A (en) Novel antitumoral use of CABAZITAXEL
MX2014012477A (es) Inhibidores pirrolopirazona de tanquirasa.
MY157341A (en) Methods and compositions for treating lung cancer
PH12015501088A1 (en) Dimeric compounds
AU2018253600A1 (en) Dosage forms and therapeutic uses of l-4-chlorokynurenine
EP4023243A3 (en) Compositions and methods for treating celiac sprue disease
TN2013000333A1 (en) Combinations comprising macitentan for the treatment of glioblastoma multiforme
MX2013014488A (es) Metodos y composiciones para tratar el cancer cerebral.
IN2014DN08477A (es)
WO2012158776A3 (en) Combination therapy for treatment of cancer
WO2013070933A3 (en) Compositions and methods for the treatment of prostate carcinoma
WO2013013238A3 (en) Compounds and related compositions and methods of use
TN2012000552A1 (en) An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative

Legal Events

Date Code Title Description
FG Grant or registration