MX2024005938A - Conjugados peptídicos de inhibidores de tubulina peptídica como agentes terapéuticos. - Google Patents

Conjugados peptídicos de inhibidores de tubulina peptídica como agentes terapéuticos.

Info

Publication number
MX2024005938A
MX2024005938A MX2024005938A MX2024005938A MX2024005938A MX 2024005938 A MX2024005938 A MX 2024005938A MX 2024005938 A MX2024005938 A MX 2024005938A MX 2024005938 A MX2024005938 A MX 2024005938A MX 2024005938 A MX2024005938 A MX 2024005938A
Authority
MX
Mexico
Prior art keywords
peptidic
therapeutics
peptide conjugates
tubulin inhibitors
tubulin
Prior art date
Application number
MX2024005938A
Other languages
English (en)
Spanish (es)
Inventor
Johanna Marie Csengery
Robert John Maguire
Original Assignee
Cybrexa 4 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cybrexa 4 Inc filed Critical Cybrexa 4 Inc
Publication of MX2024005938A publication Critical patent/MX2024005938A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
MX2024005938A 2021-11-17 2022-11-16 Conjugados peptídicos de inhibidores de tubulina peptídica como agentes terapéuticos. MX2024005938A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163280409P 2021-11-17 2021-11-17
PCT/US2022/079973 WO2023091957A1 (en) 2021-11-17 2022-11-16 Peptide conjugates of peptidic tubulin inhibitors as therapeutics

Publications (1)

Publication Number Publication Date
MX2024005938A true MX2024005938A (es) 2024-08-14

Family

ID=84799580

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2024005938A MX2024005938A (es) 2021-11-17 2022-11-16 Conjugados peptídicos de inhibidores de tubulina peptídica como agentes terapéuticos.

Country Status (14)

Country Link
US (1) US20230416331A1 (cg-RX-API-DMAC7.html)
EP (1) EP4433095A1 (cg-RX-API-DMAC7.html)
JP (1) JP2024542212A (cg-RX-API-DMAC7.html)
KR (1) KR20240130157A (cg-RX-API-DMAC7.html)
CN (1) CN118574642A (cg-RX-API-DMAC7.html)
AU (1) AU2022390891A1 (cg-RX-API-DMAC7.html)
CA (1) CA3243300A1 (cg-RX-API-DMAC7.html)
CL (1) CL2024001486A1 (cg-RX-API-DMAC7.html)
CO (1) CO2024007413A2 (cg-RX-API-DMAC7.html)
IL (1) IL312884A (cg-RX-API-DMAC7.html)
MX (1) MX2024005938A (cg-RX-API-DMAC7.html)
PE (1) PE20242180A1 (cg-RX-API-DMAC7.html)
TW (1) TW202330015A (cg-RX-API-DMAC7.html)
WO (1) WO2023091957A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022000449A (es) 2019-07-10 2022-04-25 Cybrexa 2 Inc Conjugados peptídicos de citotoxinas como terapéuticos.
BR112022000297A2 (pt) 2019-07-10 2022-03-15 Cybrexa 3 Inc Conjugados de peptídeos de agentes de alvo de microtúbulos como terapêuticos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006078816A2 (en) * 2005-01-18 2006-07-27 The Board Of Governors For Higher Education Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally senstive transmembrane peptide
EP2927227A4 (en) * 2013-01-03 2015-12-30 Celltrion Inc ANTIBODY CONCENTRATOR REMEDY CONJUGATE, METHOD OF MANUFACTURING THEREOF, AND ANTIBODY TOGETHER THEREWITH
WO2018023098A1 (en) * 2016-07-29 2018-02-01 Memorial Sloan Kettering Cancer Center Radiolabeled ligands for targeted pet/spect imaging and methods of their use
MX2022000449A (es) * 2019-07-10 2022-04-25 Cybrexa 2 Inc Conjugados peptídicos de citotoxinas como terapéuticos.
BR112022000297A2 (pt) * 2019-07-10 2022-03-15 Cybrexa 3 Inc Conjugados de peptídeos de agentes de alvo de microtúbulos como terapêuticos

Also Published As

Publication number Publication date
EP4433095A1 (en) 2024-09-25
CL2024001486A1 (es) 2024-11-29
PE20242180A1 (es) 2024-11-07
AU2022390891A1 (en) 2024-06-06
CO2024007413A2 (es) 2024-11-18
IL312884A (en) 2024-07-01
CA3243300A1 (en) 2023-05-25
KR20240130157A (ko) 2024-08-28
TW202330015A (zh) 2023-08-01
JP2024542212A (ja) 2024-11-13
WO2023091957A1 (en) 2023-05-25
CN118574642A (zh) 2024-08-30
US20230416331A1 (en) 2023-12-28

Similar Documents

Publication Publication Date Title
PH12022550039A1 (en) Peptide conjugates of cytotoxins as therapeutics
PH12021553000A1 (en) Multispecific proteins
PH12022551013A1 (en) Pyridazinones as parp7 inhibitors
PH12022550892A1 (en) Bicyclic heterocycles as fgfr inhibitors
CR20220207A (es) Compuestos terapéuticos y métodos de uso
PH12019550140A1 (en) Piperidine-substituted mnk inhibitors and methods related thereto
PH12022500003A1 (en) Il-2 conjugates and methods of use to treat autoimmune diseases
MX2023013912A (es) Metodos para inhibir ras.
MX2023002507A (es) Inhibidores de cd73.
PH12022550037A1 (en) Peptide conjugates of microtubule-targeting agents as therapeutics
SA523442921B1 (ar) جزيئات ربط علاجية
EP4596048A3 (en) Cd73 inhibitors
MX2010005651A (es) Inhibicion de receptor de proteina de estimulacion de macrofagos (ron) y sus metodos de tratamiento.
PH12020551390A1 (en) AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS
EP4674415A3 (en) Azaquinolines as inhibitors of cd38
MX2022011163A (es) Conjugados de polipeptidos de interleucina-2 y sus usos.
MX2021010766A (es) Anticuerpos que se unen a la proteína del gen 6 inducible por el factor de necrosis tumoral (tsg-6) y usos de estos.
CL2024001486A1 (es) Conjugados peptidicos de inhibidores peptidicos de tubulina como terapeuticos.
MX2024006684A (es) Inhibidores de hdac novedosos y uso terapéutico de estos.
MX2021009863A (es) Una molecula dbait en combinacion con inhibidor de quinasa para el tratamiento del cancer.
MX2023012779A (es) Regimenes de dosificacion de conjugados de peptido de inhibidores de topoisomerasa i.
MX2025001060A (es) Degradación de proteínas dirigida de parp14 para usar en terapia.
MX2022011027A (es) Composiciones y metodos para el tratamiento del cancer.
PH12021551760A1 (en) Amino acid derivatives for the treatment of inflammatory diseases
MX2024011197A (es) Combinaciones que comprenden inhibidores de metap2 para el tratamiento de cancer.