TW202330015A - 作為治療劑之肽微管蛋白抑制劑之肽結合物 - Google Patents
作為治療劑之肽微管蛋白抑制劑之肽結合物 Download PDFInfo
- Publication number
- TW202330015A TW202330015A TW111143837A TW111143837A TW202330015A TW 202330015 A TW202330015 A TW 202330015A TW 111143837 A TW111143837 A TW 111143837A TW 111143837 A TW111143837 A TW 111143837A TW 202330015 A TW202330015 A TW 202330015A
- Authority
- TW
- Taiwan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- cancer
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163280409P | 2021-11-17 | 2021-11-17 | |
| US63/280,409 | 2021-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202330015A true TW202330015A (zh) | 2023-08-01 |
Family
ID=84799580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW111143837A TW202330015A (zh) | 2021-11-17 | 2022-11-16 | 作為治療劑之肽微管蛋白抑制劑之肽結合物 |
Country Status (14)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2022000449A (es) | 2019-07-10 | 2022-04-25 | Cybrexa 2 Inc | Conjugados peptídicos de citotoxinas como terapéuticos. |
| BR112022000297A2 (pt) | 2019-07-10 | 2022-03-15 | Cybrexa 3 Inc | Conjugados de peptídeos de agentes de alvo de microtúbulos como terapêuticos |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006078816A2 (en) * | 2005-01-18 | 2006-07-27 | The Board Of Governors For Higher Education | Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally senstive transmembrane peptide |
| EP2927227A4 (en) * | 2013-01-03 | 2015-12-30 | Celltrion Inc | ANTIBODY CONCENTRATOR REMEDY CONJUGATE, METHOD OF MANUFACTURING THEREOF, AND ANTIBODY TOGETHER THEREWITH |
| WO2018023098A1 (en) * | 2016-07-29 | 2018-02-01 | Memorial Sloan Kettering Cancer Center | Radiolabeled ligands for targeted pet/spect imaging and methods of their use |
| MX2022000449A (es) * | 2019-07-10 | 2022-04-25 | Cybrexa 2 Inc | Conjugados peptídicos de citotoxinas como terapéuticos. |
| BR112022000297A2 (pt) * | 2019-07-10 | 2022-03-15 | Cybrexa 3 Inc | Conjugados de peptídeos de agentes de alvo de microtúbulos como terapêuticos |
-
2022
- 2022-11-16 AU AU2022390891A patent/AU2022390891A1/en active Pending
- 2022-11-16 EP EP22836006.1A patent/EP4433095A1/en active Pending
- 2022-11-16 CN CN202280089024.1A patent/CN118574642A/zh active Pending
- 2022-11-16 US US18/056,117 patent/US20230416331A1/en active Pending
- 2022-11-16 MX MX2024005938A patent/MX2024005938A/es unknown
- 2022-11-16 CA CA3243300A patent/CA3243300A1/en active Pending
- 2022-11-16 WO PCT/US2022/079973 patent/WO2023091957A1/en not_active Ceased
- 2022-11-16 JP JP2024529599A patent/JP2024542212A/ja active Pending
- 2022-11-16 TW TW111143837A patent/TW202330015A/zh unknown
- 2022-11-16 IL IL312884A patent/IL312884A/en unknown
- 2022-11-16 PE PE2024001102A patent/PE20242180A1/es unknown
- 2022-11-16 KR KR1020247020055A patent/KR20240130157A/ko active Pending
-
2024
- 2024-05-16 CL CL2024001486A patent/CL2024001486A1/es unknown
- 2024-06-13 CO CONC2024/0007413A patent/CO2024007413A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4433095A1 (en) | 2024-09-25 |
| CL2024001486A1 (es) | 2024-11-29 |
| PE20242180A1 (es) | 2024-11-07 |
| AU2022390891A1 (en) | 2024-06-06 |
| CO2024007413A2 (es) | 2024-11-18 |
| IL312884A (en) | 2024-07-01 |
| CA3243300A1 (en) | 2023-05-25 |
| MX2024005938A (es) | 2024-08-14 |
| KR20240130157A (ko) | 2024-08-28 |
| JP2024542212A (ja) | 2024-11-13 |
| WO2023091957A1 (en) | 2023-05-25 |
| CN118574642A (zh) | 2024-08-30 |
| US20230416331A1 (en) | 2023-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7673041B2 (ja) | 治療薬としての細胞毒素のペプチドコンジュゲート | |
| TWI820077B (zh) | 治療涉及酸性或缺氧性患病組織之疾病之化合物、組合物及方法 | |
| JP2022541749A5 (cg-RX-API-DMAC7.html) | ||
| CN112625028B (zh) | 用于抑制shp2活性的化合物和组合物 | |
| JP7675060B2 (ja) | 治療薬としての微小管標的化剤のペプチドコンジュゲート | |
| US20230416331A1 (en) | Peptide conjugates of peptidic tubulin inhibitors as therapeutics | |
| CN118475579A (zh) | 作为tead抑制剂的异双功能分子 | |
| WO2023207447A1 (zh) | 吡咯并[2,3-d]嘧啶或吡唑并[3,4-d]嘧啶衍生物及其用途 | |
| EA051761B1 (ru) | Пептидные конъюгаты агентов, нацеленных на микротрубочки, в качестве терапевтических средств | |
| WO2022155172A1 (en) | Peptide conjugates of therapeutics | |
| EA051826B1 (ru) | Пептидные конъюгаты цитотоксинов в качестве терапевтических средств | |
| WO2025151728A1 (en) | Ligand directed degrader of irak4 |