MX2024001644A - Anticuerpos contra el receptor alfa de la interleucina-4 humana. - Google Patents
Anticuerpos contra el receptor alfa de la interleucina-4 humana.Info
- Publication number
- MX2024001644A MX2024001644A MX2024001644A MX2024001644A MX2024001644A MX 2024001644 A MX2024001644 A MX 2024001644A MX 2024001644 A MX2024001644 A MX 2024001644A MX 2024001644 A MX2024001644 A MX 2024001644A MX 2024001644 A MX2024001644 A MX 2024001644A
- Authority
- MX
- Mexico
- Prior art keywords
- receptor alpha
- human interleukin
- alpha antibodies
- antibodies
- human
- Prior art date
Links
- 101001033312 Homo sapiens Interleukin-4 receptor subunit alpha Proteins 0.000 title 1
- 102000054663 human IL4R Human genes 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente descripción se relaciona con anticuerpos que se unen específicamente a IL-4Ra humano, composiciones que comprenden tales anticuerpos IL-4Ra y métodos para usar tales anticuerpos IL-4Ra.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163229836P | 2021-08-05 | 2021-08-05 | |
US202263348388P | 2022-06-02 | 2022-06-02 | |
PCT/US2022/074575 WO2023015278A1 (en) | 2021-08-05 | 2022-08-05 | Human interleukin-4 receptor alpha antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2024001644A true MX2024001644A (es) | 2024-02-27 |
Family
ID=83193316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2024001644A MX2024001644A (es) | 2021-08-05 | 2022-08-05 | Anticuerpos contra el receptor alfa de la interleucina-4 humana. |
Country Status (14)
Country | Link |
---|---|
US (1) | US11891441B2 (es) |
EP (1) | EP4380979A1 (es) |
JP (1) | JP2024530467A (es) |
KR (1) | KR20240039025A (es) |
AU (1) | AU2022324620A1 (es) |
CA (1) | CA3227516A1 (es) |
CO (1) | CO2024001251A2 (es) |
CR (1) | CR20240046A (es) |
DO (1) | DOP2024000020A (es) |
EC (1) | ECSP24009186A (es) |
IL (1) | IL310419A (es) |
MX (1) | MX2024001644A (es) |
TW (1) | TW202328183A (es) |
WO (1) | WO2023015278A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023235738A1 (en) * | 2022-06-02 | 2023-12-07 | Eli Lilly And Company | Human interleukin-4 receptor alpha antibody glucocorticoid conjugates |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2009003393A (es) * | 2006-10-02 | 2009-05-11 | Regeneron Pharma | Anticuerpos humanos de alta afinidad para el receptor de il-4 humano. |
US8092804B2 (en) * | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
JP7073487B2 (ja) | 2017-06-16 | 2022-05-23 | イーライ リリー アンド カンパニー | 操作された抗体化合物およびこれらの抱合体 |
CN110872349A (zh) | 2018-09-04 | 2020-03-10 | 三生国健药业(上海)股份有限公司 | 结合人il-4r的抗体、其制备方法和用途 |
CN111518211B (zh) | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | 抗人白介素4受体α单克隆抗体的制药用途 |
-
2022
- 2022-08-03 TW TW111129126A patent/TW202328183A/zh unknown
- 2022-08-05 IL IL310419A patent/IL310419A/en unknown
- 2022-08-05 WO PCT/US2022/074575 patent/WO2023015278A1/en active Application Filing
- 2022-08-05 AU AU2022324620A patent/AU2022324620A1/en active Pending
- 2022-08-05 JP JP2024506692A patent/JP2024530467A/ja active Pending
- 2022-08-05 KR KR1020247006757A patent/KR20240039025A/ko active Search and Examination
- 2022-08-05 CA CA3227516A patent/CA3227516A1/en active Pending
- 2022-08-05 EP EP22765359.9A patent/EP4380979A1/en active Pending
- 2022-08-05 CR CR20240046A patent/CR20240046A/es unknown
- 2022-08-05 MX MX2024001644A patent/MX2024001644A/es unknown
- 2022-08-05 US US17/817,754 patent/US11891441B2/en active Active
-
2024
- 2024-02-05 EC ECSENADI20249186A patent/ECSP24009186A/es unknown
- 2024-02-05 DO DO2024000020A patent/DOP2024000020A/es unknown
- 2024-02-06 CO CONC2024/0001251A patent/CO2024001251A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20240039025A (ko) | 2024-03-26 |
WO2023015278A1 (en) | 2023-02-09 |
IL310419A (en) | 2024-03-01 |
CO2024001251A2 (es) | 2024-03-07 |
DOP2024000020A (es) | 2024-03-28 |
TW202328183A (zh) | 2023-07-16 |
CR20240046A (es) | 2024-03-11 |
ECSP24009186A (es) | 2024-03-01 |
JP2024530467A (ja) | 2024-08-21 |
EP4380979A1 (en) | 2024-06-12 |
US20230064378A1 (en) | 2023-03-02 |
CA3227516A1 (en) | 2023-02-09 |
US11891441B2 (en) | 2024-02-06 |
AU2022324620A1 (en) | 2024-06-06 |
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