MX2022010621A - Anticuerpos anti-cd19 humano. - Google Patents

Anticuerpos anti-cd19 humano.

Info

Publication number
MX2022010621A
MX2022010621A MX2022010621A MX2022010621A MX2022010621A MX 2022010621 A MX2022010621 A MX 2022010621A MX 2022010621 A MX2022010621 A MX 2022010621A MX 2022010621 A MX2022010621 A MX 2022010621A MX 2022010621 A MX2022010621 A MX 2022010621A
Authority
MX
Mexico
Prior art keywords
antibodies
human
compositions
present disclosure
methods
Prior art date
Application number
MX2022010621A
Other languages
English (en)
Inventor
Barrett Allan
Jeffrey Streetman Boyles
Alison Lee Sim Budelsky
Songqing Na
Kira Vladimirovna Rubtsova
Guifeng Zhang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2022010621A publication Critical patent/MX2022010621A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente descripción se refiere a anticuerpos que se unen a CD19 humano ("anticuerpos anti-CD19 humano" o "anticuerpos anti-CD19 humano"), composiciones que comprenden dichos anticuerpos anti-CD19 humano y métodos para usar dichos anticuerpos anti-CD19 humano.
MX2022010621A 2020-02-28 2021-02-22 Anticuerpos anti-cd19 humano. MX2022010621A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062983093P 2020-02-28 2020-02-28
PCT/US2021/018989 WO2021173471A1 (en) 2020-02-28 2021-02-22 Anti-human cd19 antibodies

Publications (1)

Publication Number Publication Date
MX2022010621A true MX2022010621A (es) 2022-11-30

Family

ID=74885029

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022010621A MX2022010621A (es) 2020-02-28 2021-02-22 Anticuerpos anti-cd19 humano.

Country Status (20)

Country Link
US (1) US11623956B2 (es)
EP (1) EP4110815A1 (es)
JP (1) JP7450743B2 (es)
KR (1) KR20220132579A (es)
CN (1) CN115151570A (es)
AR (1) AR121370A1 (es)
AU (1) AU2021225792A1 (es)
BR (1) BR112022015902A2 (es)
CA (1) CA3169155A1 (es)
CL (1) CL2022002329A1 (es)
CO (1) CO2022012212A2 (es)
CR (1) CR20220421A (es)
DO (1) DOP2022000173A (es)
EC (1) ECSP22067275A (es)
IL (1) IL295494A (es)
JO (1) JOP20220204A1 (es)
MX (1) MX2022010621A (es)
PE (1) PE20221593A1 (es)
TW (1) TWI790548B (es)
WO (1) WO2021173471A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202346576A (zh) 2022-04-13 2023-12-01 新加坡商泰莎治療有限公司 治療性t細胞產品
US20230399375A1 (en) 2022-04-15 2023-12-14 Kyverna Therapeutics, Inc. Methods and compositions for treating autoimmune disease
WO2023240064A1 (en) 2022-06-08 2023-12-14 Kyverna Therapeutics, Inc. Methods and compositions for treating autoimmune disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1966245E (pt) 2005-12-30 2011-08-31 Merck Patent Gmbh Anticorpos anti-cd19 com imunogenicidade reduzida
US8323653B2 (en) * 2006-09-08 2012-12-04 Medimmune, Llc Humanized anti-CD19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
WO2015171863A1 (en) 2014-05-08 2015-11-12 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. USING B-CELL-TARGETING ANTIGEN IgG FUSION AS TOLEROGENIC PROTEIN THERAPY FOR TREATING ADVERSE IMMUNE RESPONSES
CA3026880A1 (en) 2016-06-08 2017-12-14 Paul Foster Treatment of igg4-related diseases with anti-cd19 antibodies crossbinding to cd32b

Also Published As

Publication number Publication date
WO2021173471A1 (en) 2021-09-02
CN115151570A (zh) 2022-10-04
AU2021225792A1 (en) 2022-09-15
TW202146451A (zh) 2021-12-16
JOP20220204A1 (ar) 2023-01-30
US20210269520A1 (en) 2021-09-02
CR20220421A (es) 2022-09-23
DOP2022000173A (es) 2022-10-31
CO2022012212A2 (es) 2022-09-09
AR121370A1 (es) 2022-06-01
JP7450743B2 (ja) 2024-03-15
PE20221593A1 (es) 2022-10-10
KR20220132579A (ko) 2022-09-30
BR112022015902A2 (pt) 2022-10-04
CL2022002329A1 (es) 2023-04-10
JP2023515219A (ja) 2023-04-12
TWI790548B (zh) 2023-01-21
IL295494A (en) 2022-10-01
US11623956B2 (en) 2023-04-11
ECSP22067275A (es) 2022-09-30
CA3169155A1 (en) 2021-09-02
EP4110815A1 (en) 2023-01-04

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