MX2023012853A - Moduladores de moleculas peque?as de la actividad de la glucocerebrosidasa y sus usos. - Google Patents
Moduladores de moleculas peque?as de la actividad de la glucocerebrosidasa y sus usos.Info
- Publication number
- MX2023012853A MX2023012853A MX2023012853A MX2023012853A MX2023012853A MX 2023012853 A MX2023012853 A MX 2023012853A MX 2023012853 A MX2023012853 A MX 2023012853A MX 2023012853 A MX2023012853 A MX 2023012853A MX 2023012853 A MX2023012853 A MX 2023012853A
- Authority
- MX
- Mexico
- Prior art keywords
- disease
- compounds
- small molecule
- molecule modulators
- glucocerebrosidase activity
- Prior art date
Links
- 102000004547 Glucosylceramidase Human genes 0.000 title abstract 4
- 108010017544 Glucosylceramidase Proteins 0.000 title abstract 4
- 230000000694 effects Effects 0.000 title abstract 2
- 150000003384 small molecules Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000015872 Gaucher disease Diseases 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 2
- 208000018737 Parkinson disease Diseases 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
En el presente documento se proporcionan compuestos que modulan la glucocerebrosidasa (GCasa), una enzima cuya actividad está asociada con enfermedades y trastornos neurológicos (por ejemplo, enfermedad de Gaucher, enfermedad de Parkinson). También se proporcionan composiciones farmacéuticas y kits que comprenden los compuestos, y métodos para tratar enfermedades y trastornos relacionados con GCasa (por ejemplo, enfermedad de Gaucher, enfermedad de Parkinson) con los compuestos en un sujeto, mediante la administración de los compuestos y/o composiciones descritos en el presente documento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163182734P | 2021-04-30 | 2021-04-30 | |
| PCT/US2022/026676 WO2022232360A1 (en) | 2021-04-30 | 2022-04-28 | Small molecule modulators of glucocerebrosidase activity and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023012853A true MX2023012853A (es) | 2024-01-12 |
Family
ID=83848814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023012853A MX2023012853A (es) | 2021-04-30 | 2022-04-28 | Moduladores de moleculas peque?as de la actividad de la glucocerebrosidasa y sus usos. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240246952A1 (es) |
| EP (1) | EP4329880A1 (es) |
| JP (1) | JP2024517789A (es) |
| KR (1) | KR20240016286A (es) |
| CN (1) | CN117751114A (es) |
| AU (1) | AU2022267285A1 (es) |
| BR (1) | BR112023022567A2 (es) |
| CA (1) | CA3218510A1 (es) |
| MX (1) | MX2023012853A (es) |
| WO (1) | WO2022232360A1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7488721B2 (en) * | 2004-05-13 | 2009-02-10 | Mcmaster University | Real time methylumbelliferone-based assay |
| CA2739490A1 (en) * | 2008-10-16 | 2010-04-22 | Schering Corporation | Pyrrolidine, piperidine and piperazine derivatives and methods of use thereof |
| WO2015095963A1 (en) * | 2013-12-23 | 2015-07-02 | Alectos Therapeutics Inc. | Glucocerebrosidase modulators and uses thereof |
-
2022
- 2022-04-28 BR BR112023022567A patent/BR112023022567A2/pt unknown
- 2022-04-28 KR KR1020237041444A patent/KR20240016286A/ko unknown
- 2022-04-28 MX MX2023012853A patent/MX2023012853A/es unknown
- 2022-04-28 US US18/288,933 patent/US20240246952A1/en active Pending
- 2022-04-28 WO PCT/US2022/026676 patent/WO2022232360A1/en active Application Filing
- 2022-04-28 CA CA3218510A patent/CA3218510A1/en active Pending
- 2022-04-28 EP EP22796703.1A patent/EP4329880A1/en active Pending
- 2022-04-28 AU AU2022267285A patent/AU2022267285A1/en active Pending
- 2022-04-28 CN CN202280046279.XA patent/CN117751114A/zh active Pending
- 2022-04-28 JP JP2023567067A patent/JP2024517789A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240246952A1 (en) | 2024-07-25 |
| CA3218510A1 (en) | 2022-11-03 |
| KR20240016286A (ko) | 2024-02-06 |
| AU2022267285A1 (en) | 2023-11-09 |
| CN117751114A (zh) | 2024-03-22 |
| EP4329880A1 (en) | 2024-03-06 |
| WO2022232360A1 (en) | 2022-11-03 |
| JP2024517789A (ja) | 2024-04-23 |
| BR112023022567A2 (pt) | 2024-02-06 |
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