MX2023011196A - Nuevo proceso para la sintesis de derivados del acido 5-{5-cloro-2-[(3s)-3-[(morfolin-4-il)metil]-3,4-dihidroisoquinoli na-2(1h)-carbonil]fenil}-1,2-dimetil-1h-pirrol-3-carboxilico y su aplicacion para la produccion de compuestos farmaceuticos. - Google Patents
Nuevo proceso para la sintesis de derivados del acido 5-{5-cloro-2-[(3s)-3-[(morfolin-4-il)metil]-3,4-dihidroisoquinoli na-2(1h)-carbonil]fenil}-1,2-dimetil-1h-pirrol-3-carboxilico y su aplicacion para la produccion de compuestos farmaceuticos.Info
- Publication number
- MX2023011196A MX2023011196A MX2023011196A MX2023011196A MX2023011196A MX 2023011196 A MX2023011196 A MX 2023011196A MX 2023011196 A MX2023011196 A MX 2023011196A MX 2023011196 A MX2023011196 A MX 2023011196A MX 2023011196 A MX2023011196 A MX 2023011196A
- Authority
- MX
- Mexico
- Prior art keywords
- new pro
- new
- pro
- arbonyl
- dihydroisoquinoline
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/50—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente invención se refiere a un nuevo proceso para preparar derivados del ácido 5-{5-cloro-2-[(3S)-3-[(morfolin-4-il)metil]-3, 4-dihidroisoquinolina-2(1H)-carbonil]fenil}-1,2-dimetil-1H-pirrol -3-carboxílico y a su aplicación para la producción de compuestos farmacéuticos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21305366 | 2021-03-24 | ||
| PCT/EP2022/057655 WO2022200444A1 (en) | 2021-03-24 | 2022-03-23 | New process for the synthesis of 5-{5-chloro-2-[(3n)-3- [(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h)- carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023011196A true MX2023011196A (es) | 2023-12-05 |
Family
ID=75497873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023011196A MX2023011196A (es) | 2021-03-24 | 2022-03-23 | Nuevo proceso para la sintesis de derivados del acido 5-{5-cloro-2-[(3s)-3-[(morfolin-4-il)metil]-3,4-dihidroisoquinoli na-2(1h)-carbonil]fenil}-1,2-dimetil-1h-pirrol-3-carboxilico y su aplicacion para la produccion de compuestos farmaceuticos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20240208926A1 (es) |
| EP (1) | EP4313964A1 (es) |
| JP (1) | JP2024511422A (es) |
| KR (1) | KR20230160303A (es) |
| CN (1) | CN116997544A (es) |
| AR (1) | AR125205A1 (es) |
| AU (1) | AU2022245255A1 (es) |
| BR (1) | BR112023018582A2 (es) |
| CA (1) | CA3214107A1 (es) |
| IL (1) | IL306011A (es) |
| MX (1) | MX2023011196A (es) |
| WO (1) | WO2022200444A1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3008975A1 (fr) | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| UY38431A (es) | 2018-10-31 | 2020-05-29 | Servier Lab | Formulación basada en ciclodextrina de un inhibidor de bcl-2 |
| LT3873894T (lt) | 2018-10-31 | 2023-06-26 | Les Laboratoires Servier | Naujoji bcl-2 inhibitoriaus druska, susijusi kristalinė forma, jos gamybos būdas ir farmacinės kompozicijos, kurių sudėtyje ji yra |
-
2022
- 2022-03-23 IL IL306011A patent/IL306011A/en unknown
- 2022-03-23 EP EP22717584.1A patent/EP4313964A1/en active Pending
- 2022-03-23 KR KR1020237035515A patent/KR20230160303A/ko unknown
- 2022-03-23 AR ARP220100687A patent/AR125205A1/es unknown
- 2022-03-23 AU AU2022245255A patent/AU2022245255A1/en active Pending
- 2022-03-23 US US18/551,033 patent/US20240208926A1/en active Pending
- 2022-03-23 CN CN202280020952.2A patent/CN116997544A/zh active Pending
- 2022-03-23 MX MX2023011196A patent/MX2023011196A/es unknown
- 2022-03-23 BR BR112023018582A patent/BR112023018582A2/pt unknown
- 2022-03-23 CA CA3214107A patent/CA3214107A1/en active Pending
- 2022-03-23 JP JP2023558161A patent/JP2024511422A/ja active Pending
- 2022-03-23 WO PCT/EP2022/057655 patent/WO2022200444A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| CN116997544A (zh) | 2023-11-03 |
| KR20230160303A (ko) | 2023-11-23 |
| BR112023018582A2 (pt) | 2023-10-24 |
| AR125205A1 (es) | 2023-06-21 |
| IL306011A (en) | 2023-11-01 |
| AU2022245255A1 (en) | 2023-09-28 |
| EP4313964A1 (en) | 2024-02-07 |
| WO2022200444A1 (en) | 2022-09-29 |
| WO2022200444A8 (en) | 2023-09-28 |
| CA3214107A1 (en) | 2022-09-29 |
| US20240208926A1 (en) | 2024-06-27 |
| JP2024511422A (ja) | 2024-03-13 |
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