MX2023009382A - Activadores de molecula peque?a de la actividad transcripcional de la proteina 1 asociada a yes (yap) para reparacion regenerativa de organos. - Google Patents

Activadores de molecula peque?a de la actividad transcripcional de la proteina 1 asociada a yes (yap) para reparacion regenerativa de organos.

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Publication number
MX2023009382A
MX2023009382A MX2023009382A MX2023009382A MX2023009382A MX 2023009382 A MX2023009382 A MX 2023009382A MX 2023009382 A MX2023009382 A MX 2023009382A MX 2023009382 A MX2023009382 A MX 2023009382A MX 2023009382 A MX2023009382 A MX 2023009382A
Authority
MX
Mexico
Prior art keywords
yap
small molecule
transcriptional activity
organ repair
molecule activators
Prior art date
Application number
MX2023009382A
Other languages
English (en)
Inventor
Peter G Schultz
Arnab K Chatterjee
Michael J Bollong
Weijun Shen
G Ralalage Elshan Nakath
Edyta M Grzelak
Pengyu Yang
Original Assignee
Scripps Research Inst
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Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of MX2023009382A publication Critical patent/MX2023009382A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • C07D498/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

La presente descripción proporciona compuestos, o sus tautómeros o sales farmacéuticamente aceptables de los mismos, y sus composiciones farmacéuticas que pueden activar selectivamente la proteína 1 asociada a Yes (YAP). Los activadores de YAP de la presente descripción son útiles en terapias tal como reparación de heridas y órganos que incluyen, por ejemplo, tratamiento de úlceras crónicas.
MX2023009382A 2021-02-12 2022-02-11 Activadores de molecula peque?a de la actividad transcripcional de la proteina 1 asociada a yes (yap) para reparacion regenerativa de organos. MX2023009382A (es)

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PCT/US2022/070631 WO2022174256A1 (en) 2021-02-12 2022-02-11 Small molecule activators of yap transcriptional activity for regenerative organ repair

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CN117222407A (zh) 2023-12-12
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CA3210977A1 (en) 2022-08-18
AU2022220863A1 (en) 2023-08-24
KR20230146054A (ko) 2023-10-18
US20240148747A1 (en) 2024-05-09
EP4291181A1 (en) 2023-12-20
IL305099A (en) 2023-10-01

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