MX2023006126A - Produccion de arn. - Google Patents
Produccion de arn.Info
- Publication number
- MX2023006126A MX2023006126A MX2023006126A MX2023006126A MX2023006126A MX 2023006126 A MX2023006126 A MX 2023006126A MX 2023006126 A MX2023006126 A MX 2023006126A MX 2023006126 A MX2023006126 A MX 2023006126A MX 2023006126 A MX2023006126 A MX 2023006126A
- Authority
- MX
- Mexico
- Prior art keywords
- rna
- rna manufacturing
- manufacturing
- dsrna
- double
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 3
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 2
- 230000001594 aberrant effect Effects 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07006—DNA-directed RNA polymerase (2.7.7.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063123465P | 2020-12-09 | 2020-12-09 | |
| US202063132473P | 2020-12-30 | 2020-12-30 | |
| PCT/EP2021/084488 WO2022122689A1 (en) | 2020-12-09 | 2021-12-07 | Rna manufacturing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023006126A true MX2023006126A (es) | 2023-07-28 |
Family
ID=79287682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023006126A MX2023006126A (es) | 2020-12-09 | 2021-12-07 | Produccion de arn. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240110214A1 (https=) |
| EP (1) | EP4259161A1 (https=) |
| JP (1) | JP2023552468A (https=) |
| KR (1) | KR20230129432A (https=) |
| AU (1) | AU2021395736A1 (https=) |
| CA (1) | CA3201552A1 (https=) |
| IL (1) | IL303457A (https=) |
| MX (1) | MX2023006126A (https=) |
| TW (1) | TW202237844A (https=) |
| WO (1) | WO2022122689A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| TW202306573A (zh) * | 2021-05-26 | 2023-02-16 | 比利時商ｅＴｈｅＲＮＡ免疫治療公司 | 減少雙股ｒｎａ副產物形成的方法 |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| JP2024534120A (ja) | 2021-08-24 | 2024-09-18 | ビオンテック・ソシエタス・エウロパエア | インビトロ転写技術 |
| CN121263517A (zh) * | 2023-02-01 | 2026-01-02 | 美国金斯瑞公司 | 体外转录方法和用于其中的化合物 |
| EP4705499A1 (en) * | 2023-05-05 | 2026-03-11 | TriLink BioTechnologies, LLC | In vitro transcription method |
| WO2025170909A1 (en) * | 2024-02-05 | 2025-08-14 | The Broad Institute, Inc. | Nucleic acids with region-specific modifications and methods of making the same |
| WO2025223684A1 (en) * | 2024-04-23 | 2025-10-30 | BioNTech SE | Methods and compositions for stimulating immune response |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7839594A (en) | 1993-09-20 | 1995-04-10 | Regents Of The University Of Colorado, The | Strategy for the production of rna from immobilized templates |
| US7074596B2 (en) | 2002-03-25 | 2006-07-11 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of anti-reverse mRNA cap analogues |
| EP2049665A2 (en) | 2006-07-28 | 2009-04-22 | Applera Corporation | Dinucleotide mrna cap analogs |
| WO2008157688A2 (en) | 2007-06-19 | 2008-12-24 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap |
| PL215513B1 (pl) | 2008-06-06 | 2013-12-31 | Univ Warszawski | Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka |
| DE102008061522A1 (de) | 2008-12-10 | 2010-06-17 | Biontech Ag | Verwendung von Flt3-Ligand zur Verstärkung von Immunreaktionen bei RNA-Immunisierung |
| EP2281579A1 (en) | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
| RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
| WO2013059475A1 (en) | 2011-10-18 | 2013-04-25 | Life Technologies Corporation | Alkynyl-derivatized cap analogs, preparation and uses thereof |
| US10837039B2 (en) | 2014-06-10 | 2020-11-17 | Curevac Real Estate Gmbh | Methods and means for enhancing RNA production |
| WO2016005004A1 (en) | 2014-07-11 | 2016-01-14 | Biontech Rna Pharmaceuticals Gmbh | Stabilization of poly(a) sequence encoding dna sequences |
| ES2964690T3 (es) | 2015-09-21 | 2024-04-09 | Trilink Biotechnologies Llc | Método para sintetizar ARN con caperuza 5' |
| WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
| EP3882343A3 (en) | 2016-01-13 | 2021-12-08 | New England Biolabs, Inc. | Thermostable variants of t7 rna polymerase |
| US10337051B2 (en) * | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| EP4599847A3 (en) | 2016-10-25 | 2025-11-12 | Trustees of Dartmouth College | Prefusion coronavirus spike proteins and their use |
-
2021
- 2021-12-07 AU AU2021395736A patent/AU2021395736A1/en active Pending
- 2021-12-07 US US18/266,135 patent/US20240110214A1/en active Pending
- 2021-12-07 CA CA3201552A patent/CA3201552A1/en active Pending
- 2021-12-07 WO PCT/EP2021/084488 patent/WO2022122689A1/en not_active Ceased
- 2021-12-07 JP JP2023534907A patent/JP2023552468A/ja active Pending
- 2021-12-07 KR KR1020237023175A patent/KR20230129432A/ko active Pending
- 2021-12-07 MX MX2023006126A patent/MX2023006126A/es unknown
- 2021-12-07 TW TW110145636A patent/TW202237844A/zh unknown
- 2021-12-07 IL IL303457A patent/IL303457A/en unknown
- 2021-12-07 EP EP21839823.8A patent/EP4259161A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022122689A1 (en) | 2022-06-16 |
| CA3201552A1 (en) | 2022-06-16 |
| EP4259161A1 (en) | 2023-10-18 |
| AU2021395736A9 (en) | 2024-05-16 |
| IL303457A (en) | 2023-08-01 |
| JP2023552468A (ja) | 2023-12-15 |
| AU2021395736A1 (en) | 2023-07-27 |
| US20240110214A1 (en) | 2024-04-04 |
| KR20230129432A (ko) | 2023-09-08 |
| TW202237844A (zh) | 2022-10-01 |
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