MX2019005149A - Arn bicatenario con modificaciones quimicas postranscripcionales. - Google Patents

Arn bicatenario con modificaciones quimicas postranscripcionales.

Info

Publication number
MX2019005149A
MX2019005149A MX2019005149A MX2019005149A MX2019005149A MX 2019005149 A MX2019005149 A MX 2019005149A MX 2019005149 A MX2019005149 A MX 2019005149A MX 2019005149 A MX2019005149 A MX 2019005149A MX 2019005149 A MX2019005149 A MX 2019005149A
Authority
MX
Mexico
Prior art keywords
chemically modified
post
double strand
modified double
strand rnas
Prior art date
Application number
MX2019005149A
Other languages
English (en)
Inventor
P Arhancet Juan
Cheerla Sreevishnu
B Arhancet Graciela
B Rozema David
Original Assignee
nanoSUR LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by nanoSUR LLC filed Critical nanoSUR LLC
Publication of MX2019005149A publication Critical patent/MX2019005149A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se describen ARN de doble cadena con modificaciones químicas postranscripcionales (MdsRNAs) que tienen más de 30 pares de bases. Los MdsRNAs inhiben la expresión de genes en organismos blanco. Tambien se describen métodos para obtener y usar MdsRNAs.
MX2019005149A 2016-11-07 2017-11-06 Arn bicatenario con modificaciones quimicas postranscripcionales. MX2019005149A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662418581P 2016-11-07 2016-11-07
US201762446722P 2017-01-16 2017-01-16
PCT/US2017/060110 WO2018085752A2 (en) 2016-11-07 2017-11-06 Post-transcriptionally chemically modified double strand rnas

Publications (1)

Publication Number Publication Date
MX2019005149A true MX2019005149A (es) 2019-06-24

Family

ID=62065473

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019005149A MX2019005149A (es) 2016-11-07 2017-11-06 Arn bicatenario con modificaciones quimicas postranscripcionales.

Country Status (8)

Country Link
US (3) US10131911B2 (es)
EP (1) EP3535274A4 (es)
JP (2) JP7094949B2 (es)
CN (1) CN110325540A (es)
BR (1) BR112019008856A2 (es)
CA (1) CA3037192A1 (es)
MX (1) MX2019005149A (es)
WO (1) WO2018085752A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3535274A4 (en) * 2016-11-07 2020-07-29 Nanosur LLC Post-transcriptionally chemically modified double stranded RNA
MX2024002299A (es) 2021-08-31 2024-03-07 nanoSUR LLC Composiciones de arnbc modificado de peso molecular elevado.

Family Cites Families (27)

* Cited by examiner, † Cited by third party
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AU4589000A (en) * 1999-04-30 2000-11-17 Cyclops Genome Sciences Limited Polynucleotides
AU2003293412A1 (en) * 2002-12-05 2004-06-30 The Research Foundation Of State University Of Newyork HIGH EFFICACY ANTISENSE RiAlpha PKA POLY-DNP OLIGORIBONUCLEOTIDES
US20040167090A1 (en) * 2003-02-21 2004-08-26 Monahan Sean D. Covalent modification of RNA for in vitro and in vivo delivery
US20040248841A1 (en) * 2003-03-13 2004-12-09 Wang Jui H. Poly-DNP-siRNA
US20050136437A1 (en) * 2003-08-25 2005-06-23 Nastech Pharmaceutical Company Inc. Nanoparticles for delivery of nucleic acids and stable double-stranded RNA
WO2007030167A1 (en) * 2005-09-02 2007-03-15 Nastech Pharmaceutical Company Inc. Modification of double-stranded ribonucleic acid molecules
US8101741B2 (en) * 2005-11-02 2012-01-24 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
WO2007134181A2 (en) * 2006-05-11 2007-11-22 Isis Pharmaceuticals, Inc. 5'-modified bicyclic nucleic acid analogs
WO2007145940A2 (en) * 2006-06-05 2007-12-21 The University Of North Carolina At Chapel Hill High-throughput rna structure analysis
CN102016036B (zh) * 2008-02-11 2015-04-08 阿克赛医药公司 经修饰的RNAi多核苷酸及其用途
JP2012147677A (ja) * 2009-05-14 2012-08-09 Nippon Shinyaku Co Ltd 二本鎖修飾ｒｎａ
EP3231872B1 (en) 2010-03-08 2020-05-06 Monsanto Technology LLC Polynucleotide molecules for gene regulation in plants
WO2011123621A2 (en) * 2010-04-01 2011-10-06 Alnylam Pharmaceuticals Inc. 2' and 5' modified monomers and oligonucleotides
EP2616543A1 (en) * 2010-09-15 2013-07-24 Alnylam Pharmaceuticals, Inc. MODIFIED iRNA AGENTS
CN103987846B (zh) * 2011-09-20 2018-06-05 苏州瑞博生物技术有限公司 一种双链核酸及其在核糖核酸酶检测中的应用和试剂盒
WO2013096866A2 (en) 2011-12-21 2013-06-27 Apse, Llc Processes using vlps with capsids resistant to hydrolases
WO2014130607A1 (en) * 2013-02-22 2014-08-28 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) MOLECULES CONTAINING A 2' INTERNUCLEOSIDE LINKAGE
CA2912131C (en) 2013-06-19 2020-07-07 Apse, Llc Oligonucleotides comprising capsid specific packaging sequences and methods of manufacture thereof
ES2675362T3 (es) 2013-07-10 2018-07-10 Basf Se ARNi para el control de hongos y oomicetos fitopatógenos mediante la inhibición de la expresión de genes CYP51
WO2015021990A1 (en) * 2013-08-16 2015-02-19 University Of Copenhagen Rna probing method and reagents
WO2015038915A2 (en) 2013-09-12 2015-03-19 Apse, Llc Compositions and methods using capsids resistant to hydrolases
US10240188B2 (en) * 2013-10-07 2019-03-26 The University Of North Carolina At Chapel Hill Detection of chemical modifications in nucleic acids
NZ719544A (en) * 2013-11-04 2022-09-30 Beeologics Inc Compositions and methods for controlling arthropod parasite and pest infestations
SG10201903290YA (en) * 2014-08-20 2019-05-30 Alnylam Pharmaceuticals Inc Modified double-stranded rna agents
EP3569711B1 (en) * 2014-12-15 2021-02-03 Dicerna Pharmaceuticals, Inc. Ligand-modified double-stranded nucleic acids
US11021707B2 (en) * 2015-10-19 2021-06-01 Phio Pharmaceuticals Corp. Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA
EP3535274A4 (en) * 2016-11-07 2020-07-29 Nanosur LLC Post-transcriptionally chemically modified double stranded RNA

Also Published As

Publication number Publication date
JP7094949B2 (ja) 2022-07-04
US11174480B2 (en) 2021-11-16
CA3037192A1 (en) 2018-05-11
US10640769B2 (en) 2020-05-05
EP3535274A4 (en) 2020-07-29
EP3535274A2 (en) 2019-09-11
BR112019008856A2 (pt) 2019-07-09
WO2018085752A2 (en) 2018-05-11
US20180127753A1 (en) 2018-05-10
CN110325540A (zh) 2019-10-11
US20190048345A1 (en) 2019-02-14
JP2022106691A (ja) 2022-07-20
JP2019534005A (ja) 2019-11-28
US20190040389A1 (en) 2019-02-07
US10131911B2 (en) 2018-11-20
WO2018085752A3 (en) 2018-06-07

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