MX2023002960A - Tecnologia de proceso para fabricacion de productos biologicos y purificacion aguas abajo. - Google Patents

Tecnologia de proceso para fabricacion de productos biologicos y purificacion aguas abajo.

Info

Publication number
MX2023002960A
MX2023002960A MX2023002960A MX2023002960A MX2023002960A MX 2023002960 A MX2023002960 A MX 2023002960A MX 2023002960 A MX2023002960 A MX 2023002960A MX 2023002960 A MX2023002960 A MX 2023002960A MX 2023002960 A MX2023002960 A MX 2023002960A
Authority
MX
Mexico
Prior art keywords
process technology
product manufacturing
downstream purification
biological product
downstream
Prior art date
Application number
MX2023002960A
Other languages
English (en)
Inventor
Jason Criscione
Ali Ersen
John R Linton
Sammy S Datwani
Original Assignee
Enquyst Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enquyst Tech Inc filed Critical Enquyst Tech Inc
Publication of MX2023002960A publication Critical patent/MX2023002960A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39516—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum from serum, plasma
    • A61K39/39525—Purification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/203—Equilibration or regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D59/00—Separation of different isotopes of the same chemical element
    • B01D59/10—Separation by diffusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B01D69/107—Organic support material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
    • B01D71/68—Polysulfones; Polyethersulfones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/24—Extraction; Separation; Purification by electrochemical means
    • C07K1/26—Electrophoresis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B01D2325/0283—Pore size
    • B01D2325/02834—Pore size more than 0.1 and up to 1 µm
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
    • B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/10—Spiral-wound membrane modules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

En este documento se proporcionan, entre otras cosas, la fabricación biológica y los procesos de purificación corriente abajo.
MX2023002960A 2020-09-14 2021-09-14 Tecnologia de proceso para fabricacion de productos biologicos y purificacion aguas abajo. MX2023002960A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063077766P 2020-09-14 2020-09-14
US202163154108P 2021-02-26 2021-02-26
US202163154109P 2021-02-26 2021-02-26
PCT/US2021/050274 WO2022056466A1 (en) 2020-09-14 2021-09-14 Process technology for biological product manufacturing and downstream purification

Publications (1)

Publication Number Publication Date
MX2023002960A true MX2023002960A (es) 2023-06-09

Family

ID=80626293

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023002960A MX2023002960A (es) 2020-09-14 2021-09-14 Tecnologia de proceso para fabricacion de productos biologicos y purificacion aguas abajo.

Country Status (10)

Country Link
US (5) US11345723B2 (es)
EP (1) EP4196244A1 (es)
JP (1) JP2023545363A (es)
KR (2) KR20240046650A (es)
CN (1) CN116367903A (es)
AU (2) AU2021340897B2 (es)
CA (1) CA3195350A1 (es)
IL (1) IL301301A (es)
MX (1) MX2023002960A (es)
WO (1) WO2022056466A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023002960A (es) 2020-09-14 2023-06-09 Enquyst Tech Inc Tecnologia de proceso para fabricacion de productos biologicos y purificacion aguas abajo.
US20220364973A1 (en) * 2021-05-13 2022-11-17 Honeywell International Inc. In situ fluid sampling device and method of using the same
WO2024008256A1 (en) * 2022-07-05 2024-01-11 Lihme Protein Solutions Improved apparatus for compound separation

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GB1354286A (en) * 1970-05-13 1974-05-22 Bagshawe K D Performance of routine chemical reactions
DE3580418D1 (de) 1984-07-31 1990-12-13 Hitachi Ltd Elektrophoretisches trennverfahren mit freier stroemung und apparat dafuer.
AU601040B2 (en) * 1987-04-03 1990-08-30 Life Therapeutics Limited Improvements relating to separation of charged molecules
US5240680A (en) * 1991-12-19 1993-08-31 Chiron Corporation Automated apparatus for use in peptide synthesis
US5640995A (en) 1995-03-14 1997-06-24 Baxter International Inc. Electrofluidic standard module and custom circuit board assembly
US5562812A (en) * 1995-04-03 1996-10-08 The Penn State Research Foundation Free flow electrophoresis device for biomolecule purification and separation in zero and one G
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6660146B2 (en) * 1999-03-29 2003-12-09 Percy H. Rhodes Method for electrophoretic focusing
US6890409B2 (en) * 2001-08-24 2005-05-10 Applera Corporation Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices
US7651619B2 (en) * 2001-12-28 2010-01-26 Danmarks Tekniske Universitet (Dtu) Filtration method and apparatus
CN100491957C (zh) * 2003-04-16 2009-05-27 株式会社崛场制作所 颗粒状物质捕集用过滤膜、使用该过滤膜的取样器以及颗粒状物质的分析装置
EP2059799B1 (en) 2006-08-29 2017-07-12 Becton Dickinson and Company Method and apparatus for carrier-free deflection electrophoresis
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ES2923018T3 (es) * 2013-03-15 2022-09-22 Glaxosmithkline Biologicals Sa Métodos de purificación de ARN
CN103331098B (zh) 2013-06-28 2015-04-01 上海交通大学 自由流电泳分离腔排气装置及其实施方法
WO2016208459A1 (ja) * 2015-06-22 2016-12-29 株式会社村田製作所 濾過装置、濾過方法、及び濾過フィルタ
GB201602946D0 (en) * 2016-02-19 2016-04-06 Fluidic Analytics Ltd And Cambridge Entpr Ltd Improvements in or relating to microfluidic free-flow electrophoresis
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Also Published As

Publication number Publication date
AU2023216891A1 (en) 2023-09-07
US20230008006A1 (en) 2023-01-12
US20220177519A1 (en) 2022-06-09
US20220081469A1 (en) 2022-03-17
EP4196244A1 (en) 2023-06-21
US11566043B2 (en) 2023-01-31
US20220356206A1 (en) 2022-11-10
JP2023545363A (ja) 2023-10-30
US20220306687A1 (en) 2022-09-29
KR20230079095A (ko) 2023-06-05
WO2022056466A1 (en) 2022-03-17
US11639367B2 (en) 2023-05-02
CA3195350A1 (en) 2022-03-17
US11396526B2 (en) 2022-07-26
AU2021340897A1 (en) 2023-05-18
US11345723B2 (en) 2022-05-31
KR20240046650A (ko) 2024-04-09
AU2021340897B2 (en) 2023-05-25
KR102655056B1 (ko) 2024-04-09
CN116367903A (zh) 2023-06-30
IL301301A (en) 2023-05-01

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