MX2023005630A - Un profarmaco de un compuesto de hexahidro-\03b2-acido, composicion de pienso del mismo, y uso del mismo. - Google Patents
Un profarmaco de un compuesto de hexahidro-\03b2-acido, composicion de pienso del mismo, y uso del mismo.Info
- Publication number
- MX2023005630A MX2023005630A MX2023005630A MX2023005630A MX2023005630A MX 2023005630 A MX2023005630 A MX 2023005630A MX 2023005630 A MX2023005630 A MX 2023005630A MX 2023005630 A MX2023005630 A MX 2023005630A MX 2023005630 A MX2023005630 A MX 2023005630A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- hexahydro
- beta
- acid component
- component compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 12
- 239000002243 precursor Substances 0.000 title abstract 5
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 abstract 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000009395 breeding Methods 0.000 abstract 1
- 230000001488 breeding effect Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- -1 compound propionate Chemical class 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/16—Acetic acid esters of dihydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/28—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/80—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención divulga los profármacos de compuestos de hexahidro-ß-ácido, una composición de pienso de los mismos y un uso de los mismos, y un profármaco de compuesto de hexahidro-ß-ácido de fórmula (I), o solvatos del mismo, o sales aceptables para piensos del mismo, en donde, R1 es un alquilo C1-C2 sustituido o sin sustituir, y cada uno de R2 y R3 se selecciona independientemente de H y un carbonilo C2-C4 lineal o ramificado, en donde el carbonilo C2-C4 está sustituido o sin sustituir. En el presente documento se descubre que un profármaco de un compuesto de hexahidro-ß-ácido de la esterificación por ácido alifático, presenta una excelente estabilidad a alta temperatura, para superar el problema resultante de la degradación del compuesto de hexahidro-ß-ácido en un proceso de granulación a alta temperatura. Por otro lado, en el presente documento se descubre que, tanto el propionato como el butirato, los profármacos de un compuesto de hexahidro-ß-ácido procedente de la esterificación por ácido alifático, y la sal aceptable para piensos de los mismos y el solvato de los mismos, son estables en el procesamiento de piensos a alta temperatura y consiguen efectos sustancialmente iguales a los del compuesto de hexahidro-ß-ácido en la cría en granjas. (ver Fórmulas).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011314243.4A CN112500289B (zh) | 2020-11-20 | 2020-11-20 | 六氢-β-酸组分化合物的前体化合物、饲用组合物及其应用 |
| PCT/CN2021/120638 WO2022022752A1 (zh) | 2020-11-20 | 2021-09-26 | 六氢-β-酸组分化合物的前体化合物、饲用组合物及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023005630A true MX2023005630A (es) | 2023-05-24 |
Family
ID=74958150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023005630A MX2023005630A (es) | 2020-11-20 | 2021-09-26 | Un profarmaco de un compuesto de hexahidro-\03b2-acido, composicion de pienso del mismo, y uso del mismo. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP4209481A4 (es) |
| JP (1) | JP2023548235A (es) |
| KR (1) | KR20230084296A (es) |
| CN (1) | CN112500289B (es) |
| AR (1) | AR124086A1 (es) |
| AU (1) | AU2021317552B2 (es) |
| CA (1) | CA3198485A1 (es) |
| IL (1) | IL302682A (es) |
| MX (1) | MX2023005630A (es) |
| WO (1) | WO2022022752A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112500289B (zh) * | 2020-11-20 | 2023-12-26 | 广州英赛特生物技术有限公司 | 六氢-β-酸组分化合物的前体化合物、饲用组合物及其应用 |
| CN113476431B (zh) * | 2021-08-13 | 2023-07-11 | 广州英赛特生物技术有限公司 | 一种环三酮衍生物在制备动物用药中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009542262A (ja) * | 2006-03-29 | 2009-12-03 | ハース，ジョン，アイ． | ホップ酸アルカリ塩を含む抗菌性組成物及びその用途 |
| KR20140116512A (ko) * | 2012-01-19 | 2014-10-02 | 디에스엠 아이피 어셋츠 비.브이. | 전분 기질내에 홉산 염을 포함하는 비들렛 |
| CN103980104B (zh) * | 2014-02-19 | 2015-10-28 | 广州英赛特生物技术有限公司 | 六氢β-酸单酯、内络盐或单酯盐及其做为动物饲料添加剂的应用 |
| CN104710307A (zh) * | 2015-02-16 | 2015-06-17 | 广州英赛特生物技术有限公司 | 六氢β-酸双脂肪酸酯及其做作为动物饲料添加剂的应用 |
| CN106074471B (zh) * | 2016-07-14 | 2018-12-07 | 新疆大学 | 一种新型抑菌剂六氢β-酸环糊精包合物的制备方法 |
| AU2019446553B2 (en) * | 2019-05-23 | 2023-07-13 | Anipha Technologies Pty Ltd | Feed composition comprising hexahydro-β-acid component compounds and application thereof |
| CN112500289B (zh) * | 2020-11-20 | 2023-12-26 | 广州英赛特生物技术有限公司 | 六氢-β-酸组分化合物的前体化合物、饲用组合物及其应用 |
-
2020
- 2020-11-20 CN CN202011314243.4A patent/CN112500289B/zh active Active
-
2021
- 2021-09-26 IL IL302682A patent/IL302682A/en unknown
- 2021-09-26 WO PCT/CN2021/120638 patent/WO2022022752A1/zh active Application Filing
- 2021-09-26 JP JP2023527418A patent/JP2023548235A/ja active Pending
- 2021-09-26 CA CA3198485A patent/CA3198485A1/en active Pending
- 2021-09-26 MX MX2023005630A patent/MX2023005630A/es unknown
- 2021-09-26 EP EP21848769.2A patent/EP4209481A4/en active Pending
- 2021-09-26 AU AU2021317552A patent/AU2021317552B2/en active Active
- 2021-09-26 KR KR1020237015891A patent/KR20230084296A/ko unknown
- 2021-11-18 AR ARP210103180A patent/AR124086A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4209481A4 (en) | 2024-10-16 |
| AU2021317552A1 (en) | 2023-06-15 |
| CA3198485A1 (en) | 2022-02-03 |
| AR124086A1 (es) | 2023-02-15 |
| KR20230084296A (ko) | 2023-06-12 |
| IL302682A (en) | 2023-07-01 |
| CN112500289A (zh) | 2021-03-16 |
| AU2021317552B2 (en) | 2024-08-22 |
| WO2022022752A1 (zh) | 2022-02-03 |
| EP4209481A1 (en) | 2023-07-12 |
| CN112500289B (zh) | 2023-12-26 |
| JP2023548235A (ja) | 2023-11-15 |
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