MX2023002650A - Metodos de tratamiento del dolor por cancer mediante la administracion de un inhibidor de pd-1. - Google Patents

Metodos de tratamiento del dolor por cancer mediante la administracion de un inhibidor de pd-1.

Info

Publication number
MX2023002650A
MX2023002650A MX2023002650A MX2023002650A MX2023002650A MX 2023002650 A MX2023002650 A MX 2023002650A MX 2023002650 A MX2023002650 A MX 2023002650A MX 2023002650 A MX2023002650 A MX 2023002650A MX 2023002650 A MX2023002650 A MX 2023002650A
Authority
MX
Mexico
Prior art keywords
patient
inhibitor
administering
methods
cancer
Prior art date
Application number
MX2023002650A
Other languages
English (en)
Inventor
Chieh-I Chen
Medha R Sasane
Denise P Bury-Maynard
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2023002650A publication Critical patent/MX2023002650A/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente descripción provee métodos para tratar o inhibir el dolor por cáncer en un paciente que lo necesite, incluida la selección de un paciente con cáncer y la administración al paciente de una cantidad terapéuticamente eficaz de un inhibidor de muerte programada 1 (PD-1). La presente descripción también provee métodos para reducir el uso de analgésicos en un paciente que lo necesite, incluida la selección de un paciente con cáncer y la administración al paciente de una cantidad terapéuticamente eficaz de un inhibidor de PD-1, en donde el paciente está siendo tratado con una terapia con analgésicos de base antes de la administración del inhibidor de PD-1. En algunas modalidades, los métodos descritos conducen al mismo tiempo a la regresión del tumor, la reducción del dolor y la reducción del uso de la terapia con analgésicos.
MX2023002650A 2020-09-03 2021-09-02 Metodos de tratamiento del dolor por cancer mediante la administracion de un inhibidor de pd-1. MX2023002650A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063074282P 2020-09-03 2020-09-03
US202163161519P 2021-03-16 2021-03-16
US202163186375P 2021-05-10 2021-05-10
EP21315132 2021-07-29
PCT/US2021/048785 WO2022051448A1 (en) 2020-09-03 2021-09-02 Methods of treating cancer pain by administering a pd-1 inhibitor

Publications (1)

Publication Number Publication Date
MX2023002650A true MX2023002650A (es) 2023-06-08

Family

ID=77924529

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023002650A MX2023002650A (es) 2020-09-03 2021-09-02 Metodos de tratamiento del dolor por cancer mediante la administracion de un inhibidor de pd-1.

Country Status (10)

Country Link
US (1) US11932692B2 (es)
EP (1) EP4208258A1 (es)
JP (1) JP2023542490A (es)
KR (1) KR20230061499A (es)
CN (1) CN116194142A (es)
AU (1) AU2021337650A1 (es)
CA (1) CA3170207A1 (es)
IL (1) IL300975A (es)
MX (1) MX2023002650A (es)
WO (1) WO2022051448A1 (es)

Family Cites Families (34)

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PT2206517T (pt) 2002-07-03 2023-11-07 Tasuku Honjo Composições de imunopotenciação contendo anticorpos anti-pd-l1
ES2367430T3 (es) 2002-12-23 2011-11-03 Wyeth Llc Anticuerpos contra pd-1 y sus usos.
EP1591527B1 (en) 2003-01-23 2015-08-26 Ono Pharmaceutical Co., Ltd. Substance specific to human pd-1
US8257740B1 (en) 2011-08-15 2012-09-04 Gp Medical, Inc. Pharmaceutical composition of nanoparticles
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RS53072B (en) 2007-06-18 2014-04-30 Merck Sharp & Dohme B.V. HUMAN RECEPTOR ANTIBODIES PROGRAMMED DEATH PD-1
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PL2342226T3 (pl) 2008-09-26 2017-01-31 Dana-Farber Cancer Institute, Inc. Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania
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Also Published As

Publication number Publication date
AU2021337650A9 (en) 2024-06-13
KR20230061499A (ko) 2023-05-08
CN116194142A (zh) 2023-05-30
CA3170207A1 (en) 2022-03-10
IL300975A (en) 2023-04-01
WO2022051448A1 (en) 2022-03-10
US20220064304A1 (en) 2022-03-03
US11932692B2 (en) 2024-03-19
AU2021337650A1 (en) 2023-05-04
EP4208258A1 (en) 2023-07-12
JP2023542490A (ja) 2023-10-10

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