MX2023001504A - Compuestos como inhibidores del receptor del componente complemento 5a (c5ar). - Google Patents

Compuestos como inhibidores del receptor del componente complemento 5a (c5ar).

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Publication number
MX2023001504A
MX2023001504A MX2023001504A MX2023001504A MX2023001504A MX 2023001504 A MX2023001504 A MX 2023001504A MX 2023001504 A MX2023001504 A MX 2023001504A MX 2023001504 A MX2023001504 A MX 2023001504A MX 2023001504 A MX2023001504 A MX 2023001504A
Authority
MX
Mexico
Prior art keywords
compounds
c5ar inhibitors
inhibitors
c5ar
methods
Prior art date
Application number
MX2023001504A
Other languages
English (en)
Inventor
Xihua Zhu
Gonghua Pan
Yingjie Zhu
Original Assignee
Kira Pharmaceuticals Suzhou Ltd
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Publication date
Application filed by Kira Pharmaceuticals Suzhou Ltd filed Critical Kira Pharmaceuticals Suzhou Ltd
Publication of MX2023001504A publication Critical patent/MX2023001504A/es

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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invención generalmente se refiere a inhibidores del receptor de C5a, a composiciones de los mismos, a métodos de uso de los mismos y a métodos de preparación de los mismos.
MX2023001504A 2020-08-07 2021-08-06 Compuestos como inhibidores del receptor del componente complemento 5a (c5ar). MX2023001504A (es)

Applications Claiming Priority (2)

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CN2020107800 2020-08-07
PCT/CN2021/111236 WO2022028586A1 (en) 2020-08-07 2021-08-06 Compounds as c5ar inhibitors

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MX2023001504A true MX2023001504A (es) 2023-04-27

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US (1) US20240043439A1 (es)
EP (1) EP4192816A1 (es)
JP (1) JP2023537062A (es)
KR (1) KR20230050364A (es)
CN (1) CN116322683A (es)
AU (1) AU2021321901A1 (es)
CA (1) CA3179156A1 (es)
IL (1) IL300375A (es)
MX (1) MX2023001504A (es)
WO (1) WO2022028586A1 (es)

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CN117402104A (zh) * 2021-12-06 2024-01-16 重庆医科大学 阿伐可泮手性中间体的制备方法
CN114262291B (zh) * 2022-01-04 2023-05-19 重庆医科大学 一种阿伐可泮的合成方法

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