MX2023001050A - Ruta sintetica escalable para la psilocina y la psilocibina. - Google Patents
Ruta sintetica escalable para la psilocina y la psilocibina.Info
- Publication number
- MX2023001050A MX2023001050A MX2023001050A MX2023001050A MX2023001050A MX 2023001050 A MX2023001050 A MX 2023001050A MX 2023001050 A MX2023001050 A MX 2023001050A MX 2023001050 A MX2023001050 A MX 2023001050A MX 2023001050 A MX2023001050 A MX 2023001050A
- Authority
- MX
- Mexico
- Prior art keywords
- psilocybin
- psilocin
- synthetic route
- disorders
- scalable synthetic
- Prior art date
Links
- QVDSEJDULKLHCG-UHFFFAOYSA-N Psilocybine Natural products C1=CC(OP(O)(O)=O)=C2C(CCN(C)C)=CNC2=C1 QVDSEJDULKLHCG-UHFFFAOYSA-N 0.000 title abstract 3
- QKTAAWLCLHMUTJ-UHFFFAOYSA-N psilocybin Chemical compound C1C=CC(OP(O)(O)=O)=C2C(CCN(C)C)=CN=C21 QKTAAWLCLHMUTJ-UHFFFAOYSA-N 0.000 title abstract 3
- SPCIYGNTAMCTRO-UHFFFAOYSA-N Psilocine Natural products C1=CC(O)=C2C(CCN(C)C)=CNC2=C1 SPCIYGNTAMCTRO-UHFFFAOYSA-N 0.000 title 1
- ZBWSBXGHYDWMAK-UHFFFAOYSA-N psilocin Chemical compound C1=CC=C(O)[C]2C(CCN(C)C)=CN=C21 ZBWSBXGHYDWMAK-UHFFFAOYSA-N 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010012335 Dependence Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000024714 major depressive disease Diseases 0.000 abstract 1
- 230000004630 mental health Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente solicitud se refiere a rutas sintéticas escalables, rentables y prácticas para la síntesis de la psilocibina (Fórmula I) y su metabolito principal psilocina (Fórmula II) y sus sales farmacéuticamente aceptables. Estos compuestos son útiles para el tratamiento o la prevención de trastornos mentales, como el trastorno depresivo mayor, la ansiedad y los trastornos de adicción, entre otros trastornos del SNC. (Fórmula I) (Fórmula II).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063056058P | 2020-07-24 | 2020-07-24 | |
PCT/CA2021/051029 WO2022016289A1 (en) | 2020-07-24 | 2021-07-23 | Scalable synthetic route for psilocin and psilocybin |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023001050A true MX2023001050A (es) | 2023-03-31 |
Family
ID=79729544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023001050A MX2023001050A (es) | 2020-07-24 | 2021-07-23 | Ruta sintetica escalable para la psilocina y la psilocibina. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230286916A1 (es) |
EP (1) | EP4185565A1 (es) |
JP (1) | JP2023535742A (es) |
KR (1) | KR20230044460A (es) |
CN (1) | CN116348448A (es) |
AU (1) | AU2021311493A1 (es) |
BR (1) | BR112023001278A2 (es) |
CA (1) | CA3186854A1 (es) |
IL (1) | IL300154A (es) |
MX (1) | MX2023001050A (es) |
WO (1) | WO2022016289A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3152752A1 (en) * | 2019-10-01 | 2021-04-08 | Thomas Henley | Genetic engineering of fungi to modulate tryptamine expression |
EP4153564A4 (en) | 2020-05-19 | 2024-06-19 | Cybin IRL Limited | DEUTERATED TRYPTAMINE DERIVATIVES AND METHODS OF USE |
WO2023044577A1 (en) * | 2021-09-24 | 2023-03-30 | Psygen Inc. | Recovery method for tryptamines |
WO2023173227A1 (en) * | 2022-03-18 | 2023-09-21 | Enveric Biosciences Canada Inc. | C4-substituted tryptamine derivatives and methods of using |
WO2024015447A1 (en) * | 2022-07-12 | 2024-01-18 | Lobe Sciences Ltd. | Preparation of stable psilocin salts, esters and conjugates and uses thereof |
WO2024062080A1 (en) | 2022-09-21 | 2024-03-28 | Carbogen Amcis Ag | Improved synthesis of psilocybin derivatives |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU36879A1 (es) * | 1958-02-21 | |||
GB2571696B (en) * | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
-
2021
- 2021-07-23 AU AU2021311493A patent/AU2021311493A1/en active Pending
- 2021-07-23 KR KR1020237006330A patent/KR20230044460A/ko unknown
- 2021-07-23 JP JP2023504807A patent/JP2023535742A/ja active Pending
- 2021-07-23 CN CN202180064420.4A patent/CN116348448A/zh active Pending
- 2021-07-23 EP EP21845195.3A patent/EP4185565A1/en active Pending
- 2021-07-23 MX MX2023001050A patent/MX2023001050A/es unknown
- 2021-07-23 BR BR112023001278A patent/BR112023001278A2/pt unknown
- 2021-07-23 IL IL300154A patent/IL300154A/en unknown
- 2021-07-23 WO PCT/CA2021/051029 patent/WO2022016289A1/en active Application Filing
- 2021-07-23 CA CA3186854A patent/CA3186854A1/en active Pending
- 2021-07-23 US US18/017,197 patent/US20230286916A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4185565A1 (en) | 2023-05-31 |
IL300154A (en) | 2023-03-01 |
CN116348448A (zh) | 2023-06-27 |
BR112023001278A2 (pt) | 2023-04-04 |
AU2021311493A1 (en) | 2023-03-16 |
JP2023535742A (ja) | 2023-08-21 |
WO2022016289A1 (en) | 2022-01-27 |
KR20230044460A (ko) | 2023-04-04 |
CA3186854A1 (en) | 2022-01-27 |
US20230286916A1 (en) | 2023-09-14 |
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