MX2023000261A - 1-[1-(4-benciloxi-3,5-difluoro-benzoil)-4-fluoro-pirrolidin-2-car bonil]-pirrolidin-2-carbonitrilo. - Google Patents

1-[1-(4-benciloxi-3,5-difluoro-benzoil)-4-fluoro-pirrolidin-2-car bonil]-pirrolidin-2-carbonitrilo.

Info

Publication number
MX2023000261A
MX2023000261A MX2023000261A MX2023000261A MX2023000261A MX 2023000261 A MX2023000261 A MX 2023000261A MX 2023000261 A MX2023000261 A MX 2023000261A MX 2023000261 A MX2023000261 A MX 2023000261A MX 2023000261 A MX2023000261 A MX 2023000261A
Authority
MX
Mexico
Prior art keywords
pyrrolidine
benzyloxy
difluoro
benzoyl
fluoro
Prior art date
Application number
MX2023000261A
Other languages
English (en)
Inventor
Clua Teresa Tarragó
Cosano Roger Prades
Original Assignee
Accure Therapeutics S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Accure Therapeutics S L filed Critical Accure Therapeutics S L
Publication of MX2023000261A publication Critical patent/MX2023000261A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente invención se refiere a derivados de 1-[1-(4-benciloxi-3,5-difluoro-benzoil)-4-fluoro-pirrolidin-2-car bonil]-pirrolidin-2-carbonitrilo que tienen actividad farmacológica, (ver Fórmula) (I) a procedimientos de preparación de tales compuestos, a composiciones farmacéuticas que los comprenden y a su uso en terapia y/o profilaxis de un trastorno cognitivo.
MX2023000261A 2020-07-07 2021-07-06 1-[1-(4-benciloxi-3,5-difluoro-benzoil)-4-fluoro-pirrolidin-2-car bonil]-pirrolidin-2-carbonitrilo. MX2023000261A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20382606 2020-07-07
PCT/EP2021/068577 WO2022008477A1 (en) 2020-07-07 2021-07-06 1-[1-(4-benzyloxy-3,5-difluoro-benzoyl)-4-fluoro-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile

Publications (1)

Publication Number Publication Date
MX2023000261A true MX2023000261A (es) 2023-04-13

Family

ID=71607883

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023000261A MX2023000261A (es) 2020-07-07 2021-07-06 1-[1-(4-benciloxi-3,5-difluoro-benzoil)-4-fluoro-pirrolidin-2-car bonil]-pirrolidin-2-carbonitrilo.

Country Status (13)

Country Link
US (1) US20230250058A1 (es)
EP (1) EP4178945A1 (es)
JP (1) JP2023533932A (es)
KR (1) KR20230035604A (es)
CN (1) CN117545738A (es)
AU (1) AU2021303440A1 (es)
BR (1) BR112023000335A2 (es)
CA (1) CA3185064A1 (es)
IL (1) IL299035A (es)
MX (1) MX2023000261A (es)
TW (1) TW202216689A (es)
WO (1) WO2022008477A1 (es)
ZA (1) ZA202213708B (es)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159938A (en) 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
DE19603510A1 (de) 1996-02-01 1997-08-07 Knoell Hans Forschung Ev Die Verwendung von Terrecyclolsäure A und Terrecyclolsäure A-Derivate als neue Inhibitoren der humanen Prolyl-Oligopeptidase
FI20011466A0 (fi) 2001-07-04 2001-07-04 Orion Corp Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä, niiden valmistusmenetelmiä ja käyttö
FI20030014A0 (fi) 2003-01-03 2003-01-03 Orion Corp Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä
FI20031018A0 (fi) 2003-07-04 2003-07-04 Orion Corp Parannus aivovammasta toipumiseen
JP4630192B2 (ja) 2003-09-24 2011-02-09 日本化薬株式会社 プロリルオリゴペプチダーゼ阻害剤
US7667044B2 (en) 2003-11-03 2010-02-23 Probiodrug Ag Compounds for the treatment of neurological disorders
ES2302473B1 (es) 2006-12-22 2009-06-12 Universidad De Barcelona Agente terapeutico para el tratamiento del desorden afectivo bipolar en mamiferos.
EP2730571A1 (en) 2012-11-12 2014-05-14 Universitat De Barcelona 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives

Also Published As

Publication number Publication date
BR112023000335A2 (pt) 2023-01-31
CN117545738A (zh) 2024-02-09
CA3185064A1 (en) 2022-01-13
JP2023533932A (ja) 2023-08-07
EP4178945A1 (en) 2023-05-17
US20230250058A1 (en) 2023-08-10
WO2022008477A1 (en) 2022-01-13
IL299035A (en) 2023-02-01
AU2021303440A1 (en) 2023-02-02
TW202216689A (zh) 2022-05-01
ZA202213708B (en) 2024-04-24
KR20230035604A (ko) 2023-03-14

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