MX2022016281A - Composiciones y metodos antivirales de amplio espectro. - Google Patents
Composiciones y metodos antivirales de amplio espectro.Info
- Publication number
- MX2022016281A MX2022016281A MX2022016281A MX2022016281A MX2022016281A MX 2022016281 A MX2022016281 A MX 2022016281A MX 2022016281 A MX2022016281 A MX 2022016281A MX 2022016281 A MX2022016281 A MX 2022016281A MX 2022016281 A MX2022016281 A MX 2022016281A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- broad spectrum
- spectrum antiviral
- antiviral compositions
- presented
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- 241000701024 Human betaherpesvirus 5 Species 0.000 abstract 1
- 241000829111 Human polyomavirus 1 Species 0.000 abstract 1
- 241000724205 Rice stripe tenuivirus Species 0.000 abstract 1
- 241000907316 Zika virus Species 0.000 abstract 1
- 238000000423 cell based assay Methods 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Se presentan nuevos compuestos que contienen tiazol e isoquinolina que son útiles para tratar y/o prevenir infecciones virales de amplio espectro. También se presentan métodos para tratar y/o prevenir infecciones virales de amplio espectro. Estos compuestos han mostrado inhibición de la replicación de HCMV, virus de la influenza, virus Zika, virus BK y RSV en ensayos a base de células.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762574067P | 2017-10-18 | 2017-10-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022016281A true MX2022016281A (es) | 2023-02-09 |
Family
ID=66173872
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020004475A MX2020004475A (es) | 2017-10-18 | 2018-10-17 | Composiciones y metodos antivirales de amplio espectro. |
MX2022016281A MX2022016281A (es) | 2017-10-18 | 2020-07-13 | Composiciones y metodos antivirales de amplio espectro. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020004475A MX2020004475A (es) | 2017-10-18 | 2018-10-17 | Composiciones y metodos antivirales de amplio espectro. |
Country Status (11)
Country | Link |
---|---|
US (2) | US11459321B2 (es) |
EP (1) | EP3697783A4 (es) |
JP (2) | JP7342010B2 (es) |
KR (1) | KR20200060772A (es) |
CN (1) | CN111819175A (es) |
AU (2) | AU2018350999B2 (es) |
BR (1) | BR112020007879A2 (es) |
CA (1) | CA3079396A1 (es) |
IL (1) | IL273990B1 (es) |
MX (2) | MX2020004475A (es) |
WO (1) | WO2019079519A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018005939A1 (en) | 2016-07-01 | 2018-01-04 | The Board Of Regents Of The University Of Texas System | Methods, apparatuses, and systems for creating 3-dimensional representations exhibiting geometric and surface characteristics of brain lesions |
EP4271675A1 (en) * | 2020-12-31 | 2023-11-08 | Evrys Bio, LLC | Anti-tumor compositions and methods |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
US6042820A (en) | 1996-12-20 | 2000-03-28 | Connaught Laboratories Limited | Biodegradable copolymer containing α-hydroxy acid and α-amino acid units |
US6472375B1 (en) | 1998-04-16 | 2002-10-29 | John Wayne Cancer Institute | DNA vaccine and methods for its use |
EP2125778A1 (en) | 2006-12-22 | 2009-12-02 | Millennium Pharmaceuticals, Inc. | Certain pyrazoline derivatives with kinase inhibitory activity |
US20150335657A1 (en) * | 2014-05-05 | 2015-11-26 | The Trustees Of Princeton University | Methods for Modulating Sirtuin Enzymes |
WO2016027879A1 (ja) * | 2014-08-22 | 2016-02-25 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有する多環性ピリドン誘導体 |
WO2016077240A2 (en) | 2014-11-10 | 2016-05-19 | Forge Life Science, Llc | Anti-hcmv compositions and methods |
AU2015346657B9 (en) * | 2014-11-10 | 2020-01-16 | Evrys Bio, Llc | Anti-HCMV compositions and methods |
WO2016107832A1 (en) * | 2014-12-30 | 2016-07-07 | F. Hoffmann-La Roche Ag | Novel tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis b virus infection |
WO2016177655A1 (en) * | 2015-05-04 | 2016-11-10 | F. Hoffmann-La Roche Ag | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of hbsag (hbv surface antigen) and hbv dna production for the treatment of hepatitis b virus infections |
-
2018
- 2018-10-17 WO PCT/US2018/056379 patent/WO2019079519A1/en unknown
- 2018-10-17 BR BR112020007879-4A patent/BR112020007879A2/pt unknown
- 2018-10-17 CA CA3079396A patent/CA3079396A1/en active Pending
- 2018-10-17 EP EP18868049.0A patent/EP3697783A4/en active Pending
- 2018-10-17 KR KR1020207014239A patent/KR20200060772A/ko not_active Application Discontinuation
- 2018-10-17 AU AU2018350999A patent/AU2018350999B2/en active Active
- 2018-10-17 US US16/756,734 patent/US11459321B2/en active Active
- 2018-10-17 JP JP2020542541A patent/JP7342010B2/ja active Active
- 2018-10-17 MX MX2020004475A patent/MX2020004475A/es unknown
- 2018-10-17 CN CN201880080152.3A patent/CN111819175A/zh active Pending
-
2020
- 2020-04-16 IL IL273990A patent/IL273990B1/en unknown
- 2020-07-13 MX MX2022016281A patent/MX2022016281A/es unknown
-
2022
- 2022-07-14 US US17/865,060 patent/US20230416241A1/en active Pending
- 2022-10-18 AU AU2022256094A patent/AU2022256094B2/en active Active
-
2023
- 2023-08-30 JP JP2023140497A patent/JP2023162363A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2021500401A (ja) | 2021-01-07 |
KR20200060772A (ko) | 2020-06-01 |
JP7342010B2 (ja) | 2023-09-11 |
JP2023162363A (ja) | 2023-11-08 |
EP3697783A4 (en) | 2023-04-26 |
IL273990A (en) | 2020-05-31 |
RU2020114888A3 (es) | 2021-11-18 |
AU2018350999B2 (en) | 2022-09-08 |
CA3079396A1 (en) | 2019-04-25 |
CN111819175A (zh) | 2020-10-23 |
EP3697783A1 (en) | 2020-08-26 |
US11459321B2 (en) | 2022-10-04 |
IL273990B1 (en) | 2024-07-01 |
WO2019079519A1 (en) | 2019-04-25 |
RU2020114888A (ru) | 2021-11-18 |
AU2022256094B2 (en) | 2023-07-20 |
BR112020007879A2 (pt) | 2020-10-13 |
AU2022256094A1 (en) | 2022-11-17 |
US20210139475A1 (en) | 2021-05-13 |
US20230416241A1 (en) | 2023-12-28 |
AU2018350999A1 (en) | 2020-05-07 |
MX2020004475A (es) | 2020-10-28 |
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