MX2022015611A - Ensayo basado en células para determinar la actividad de destrucción de tumores in vitro de células inmunitarias que expresan antígeno quimérico. - Google Patents

Ensayo basado en células para determinar la actividad de destrucción de tumores in vitro de células inmunitarias que expresan antígeno quimérico.

Info

Publication number
MX2022015611A
MX2022015611A MX2022015611A MX2022015611A MX2022015611A MX 2022015611 A MX2022015611 A MX 2022015611A MX 2022015611 A MX2022015611 A MX 2022015611A MX 2022015611 A MX2022015611 A MX 2022015611A MX 2022015611 A MX2022015611 A MX 2022015611A
Authority
MX
Mexico
Prior art keywords
car
immune cells
cell
chimeric antigen
determining
Prior art date
Application number
MX2022015611A
Other languages
English (en)
Inventor
J Kendall Williams
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MX2022015611A publication Critical patent/MX2022015611A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype

Abstract

La descripción proporciona un método in vitro para determinar la potencia (p. ej., citotoxicidad) de una célula inmunitaria que expresa una molécula de receptor de antígeno quimérico (CAR). En una muestra de prueba, las células inmunitarias que expresan CAR se incuban con células diana que expresan un antígeno que interactúa con el CAR. En una muestra de control, las células inmunitarias que expresan CAR se incuban con las células diana y una molécula inhibidora que evita la interacción entre el CAR y las células diana. La cantidad de muerte de células diana se determina tanto en la muestra de prueba como en la muestra de control y se comparan.
MX2022015611A 2020-06-08 2021-06-07 Ensayo basado en células para determinar la actividad de destrucción de tumores in vitro de células inmunitarias que expresan antígeno quimérico. MX2022015611A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063036249P 2020-06-08 2020-06-08
US202063125173P 2020-12-14 2020-12-14
PCT/IB2021/054996 WO2021250552A1 (en) 2020-06-08 2021-06-07 Cell-based assay for determining the in vitro tumor killing activity of chimeric antigen expressing immune cells

Publications (1)

Publication Number Publication Date
MX2022015611A true MX2022015611A (es) 2023-04-18

Family

ID=76708258

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022015611A MX2022015611A (es) 2020-06-08 2021-06-07 Ensayo basado en células para determinar la actividad de destrucción de tumores in vitro de células inmunitarias que expresan antígeno quimérico.

Country Status (10)

Country Link
US (1) US20220057381A1 (es)
EP (1) EP4162269A1 (es)
JP (1) JP2023530238A (es)
KR (1) KR20230022964A (es)
CN (1) CN115917317A (es)
AU (1) AU2021288751A1 (es)
BR (1) BR112022025026A2 (es)
CA (1) CA3186600A1 (es)
MX (1) MX2022015611A (es)
WO (1) WO2021250552A1 (es)

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US6265150B1 (en) 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
JP2004511425A (ja) 2000-02-08 2004-04-15 ザ　ペン　ステート　リサーチ　ファウンデーション 免疫療法に使用されるインターロイキン１３受容体サブユニットアルファー２
NZ612512A (en) 2010-12-09 2015-03-27 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2013126720A2 (en) * 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Compositions and methods for the assessment of target cancer cell resistance to car engineered t cell killing
US9371396B2 (en) 2012-06-15 2016-06-21 Sinomab Bioscience Limited Anti-CD22 anti-idiotypic antibodies and uses thereof
US9745368B2 (en) 2013-03-15 2017-08-29 The Trustees Of The University Of Pennsylvania Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
SG11201509609SA (en) 2013-05-24 2015-12-30 Univ Texas Chimeric antigen receptor-targeting monoclonal antibodies
IL280215B (en) 2014-04-07 2022-07-01 Novartis Ag Cancer treatment using a chimeric receptor antigen (car) against cd19
EP3712171A1 (en) 2014-08-19 2020-09-23 Novartis AG Treatment of cancer using a cd123 chimeric antigen receptor
WO2018111340A1 (en) * 2016-12-16 2018-06-21 Novartis Ag Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells
CN110662771B (zh) * 2018-02-01 2023-07-28 南京驯鹿生物技术股份有限公司 一种结合bcma的嵌合抗原受体(car)及其应用
WO2020051345A1 (en) * 2018-09-05 2020-03-12 Memorial Sloan-Kettering Cancer Center Pleural effusion-based methods for assessing immunoresponsive cell activity

Also Published As

Publication number Publication date
JP2023530238A (ja) 2023-07-14
CN115917317A (zh) 2023-04-04
CA3186600A1 (en) 2021-12-16
US20220057381A1 (en) 2022-02-24
KR20230022964A (ko) 2023-02-16
AU2021288751A1 (en) 2023-02-09
EP4162269A1 (en) 2023-04-12
WO2021250552A1 (en) 2021-12-16
BR112022025026A2 (pt) 2023-02-14

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