MX2022015338A - Santaleno sintasas sinteticas. - Google Patents

Santaleno sintasas sinteticas.

Info

Publication number
MX2022015338A
MX2022015338A MX2022015338A MX2022015338A MX2022015338A MX 2022015338 A MX2022015338 A MX 2022015338A MX 2022015338 A MX2022015338 A MX 2022015338A MX 2022015338 A MX2022015338 A MX 2022015338A MX 2022015338 A MX2022015338 A MX 2022015338A
Authority
MX
Mexico
Prior art keywords
santalene
synthetic
synthases
santalene synthases
content
Prior art date
Application number
MX2022015338A
Other languages
English (en)
Inventor
Elena Melillo
Matthew Quinn Styles
Susan Eline Bouwmeester
Niels Willems
Original Assignee
Isobionics B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isobionics B V filed Critical Isobionics B V
Publication of MX2022015338A publication Critical patent/MX2022015338A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03083—Beta-santalene synthase (4.2.3.83)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)

Abstract

Se divulgan santaleno sintasas con un perfil de producto mejorado y métodos para mejorar las santaleno sintasas. La invención se refiere además a composiciones de santaleno producidas mediante fermentación que tienen un mayor contenido de beta-santaleno con respecto al alfa-santaleno.
MX2022015338A 2020-06-04 2021-06-01 Santaleno sintasas sinteticas. MX2022015338A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20178333 2020-06-04
EP21160103 2021-03-02
PCT/EP2021/064642 WO2021245064A1 (en) 2020-06-04 2021-06-01 Synthetic santalene synthases

Publications (1)

Publication Number Publication Date
MX2022015338A true MX2022015338A (es) 2023-01-16

Family

ID=76641632

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022015338A MX2022015338A (es) 2020-06-04 2021-06-01 Santaleno sintasas sinteticas.

Country Status (8)

Country Link
US (1) US20230235310A1 (es)
EP (1) EP4162061A1 (es)
JP (1) JP2023533154A (es)
CN (1) CN115516102A (es)
AU (1) AU2021285040A1 (es)
BR (1) BR112022024475A2 (es)
MX (1) MX2022015338A (es)
WO (1) WO2021245064A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023110729A1 (en) * 2021-12-13 2023-06-22 Isobionics B.V. Recombinant manufacture of santalene

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3546806C2 (es) 1985-03-30 1991-03-28 Marc Genf/Geneve Ch Ballivet
CA2098824A1 (en) 1990-12-20 1992-06-21 William D. Huse Optimization of binding proteins
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6764835B2 (en) 1995-12-07 2004-07-20 Diversa Corporation Saturation mutageneis in directed evolution
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
CN104673784A (zh) 2007-07-31 2015-06-03 Bp法人北美有限公司 修剪式多位点组合装配
ES2410906T3 (es) 2008-03-06 2013-07-03 Firmenich S.A. Procedimiento de producción de alfa-santaleno
CN102245778B (zh) 2008-12-11 2014-06-11 弗门尼舍有限公司 用于生产β-檀香萜的方法
US8569025B2 (en) 2009-06-29 2013-10-29 The University Of British Columbia Terpene synthases from santalum
EP3126492A2 (en) 2014-03-31 2017-02-08 Evolva, Inc. Modified santalene synthase polypeptides, encoding nucleic acid molecules and uses thereof
NL2018457B1 (en) 2017-03-02 2018-09-21 Isobionics B V Santalene Synthase

Also Published As

Publication number Publication date
WO2021245064A1 (en) 2021-12-09
US20230235310A1 (en) 2023-07-27
JP2023533154A (ja) 2023-08-02
EP4162061A1 (en) 2023-04-12
AU2021285040A1 (en) 2023-01-05
CN115516102A (zh) 2022-12-23
BR112022024475A2 (pt) 2022-12-27

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