MX2022014155A - Composiciones y metodos para tratar trastornos asociados a mutaciones de perdida de funcion en syngap1. - Google Patents

Composiciones y metodos para tratar trastornos asociados a mutaciones de perdida de funcion en syngap1.

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Publication number
MX2022014155A
MX2022014155A MX2022014155A MX2022014155A MX2022014155A MX 2022014155 A MX2022014155 A MX 2022014155A MX 2022014155 A MX2022014155 A MX 2022014155A MX 2022014155 A MX2022014155 A MX 2022014155A MX 2022014155 A MX2022014155 A MX 2022014155A
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MX
Mexico
Prior art keywords
syngap1
loss
function mutations
methods
compositions
Prior art date
Application number
MX2022014155A
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English (en)
Inventor
Steven Petrou
Original Assignee
The Florey Inst Of Neuroscience And Mental Health
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Publication date
Priority claimed from AU2020901507A external-priority patent/AU2020901507A0/en
Application filed by The Florey Inst Of Neuroscience And Mental Health filed Critical The Florey Inst Of Neuroscience And Mental Health
Publication of MX2022014155A publication Critical patent/MX2022014155A/es

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    • C12Y306/05—Hydrolases acting on acid anhydrides (3.6) acting on GTP; involved in cellular and subcellular movement (3.6.5)
    • C12Y306/05002—Small monomeric GTPase (3.6.5.2)

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

La presente divulgación se refiere en general a composiciones y métodos adecuados para tratar un trastorno asociado a mutaciones de pérdida de función en SYNGAP1. Más específicamente, la divulgación se refiere a métodos para tratar un trastorno asociado a mutaciones heterocigóticas de pérdida de función de SYNGAP1 y a oligonucleótidos antisentido específicos para SYNGAP1, y a su uso para tratar un trastorno asociado a mutaciones heterocigóticas de pérdida de función de SYNGAP1.
MX2022014155A 2020-05-11 2021-05-11 Composiciones y metodos para tratar trastornos asociados a mutaciones de perdida de funcion en syngap1. MX2022014155A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2020901507A AU2020901507A0 (en) 2020-05-11 Compositions and methods for treating disorders associated with loss-of-function mutations in SYNGAP1
PCT/AU2021/050436 WO2021226663A1 (en) 2020-05-11 2021-05-11 Compositions and methods for treating disorders associated with loss-of-function mutations in syngap1

Publications (1)

Publication Number Publication Date
MX2022014155A true MX2022014155A (es) 2023-04-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022014155A MX2022014155A (es) 2020-05-11 2021-05-11 Composiciones y metodos para tratar trastornos asociados a mutaciones de perdida de funcion en syngap1.

Country Status (15)

Country Link
US (1) US20230174984A1 (es)
EP (1) EP4150094A1 (es)
JP (1) JP2023526060A (es)
KR (1) KR20230009965A (es)
CN (1) CN115916977A (es)
AU (1) AU2021272832A1 (es)
BR (1) BR112022022893A2 (es)
CA (1) CA3178334A1 (es)
CL (1) CL2022003145A1 (es)
CO (1) CO2022017705A2 (es)
EC (1) ECSP22093649A (es)
IL (1) IL298070A (es)
MX (1) MX2022014155A (es)
PE (1) PE20230739A1 (es)
WO (1) WO2021226663A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023073661A2 (en) * 2021-11-01 2023-05-04 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing psd3 expression
WO2023163801A1 (en) * 2022-02-24 2023-08-31 Q-State Biosciences, Inc. Therapeutics for syngap haploinsufficiency
WO2023196847A2 (en) * 2022-04-05 2023-10-12 The Johns Hopkins University Agents for modulating syngap1 splicing
WO2024119145A1 (en) * 2022-12-01 2024-06-06 Camp4 Therapeutics Corporation Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083695A (en) * 1996-04-15 2000-07-04 The University Of Houston Optimized primer library for gene sequencing and method of using same
MX2010003299A (es) * 2007-10-04 2010-04-14 Santaris Pharma As Oligonucleotidos muy cortos (micromirs).
EP2364325A4 (en) * 2008-11-07 2012-07-25 Ct Hospitalier Universitaire Sainte Justine SYNGAP1 DYSFUNCTIONS AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS FOR INTELLECTUAL SENTENCING
WO2016201272A1 (en) * 2015-06-12 2016-12-15 King Abdulaziz City For Science And Technology Method of diagnosing patients with conditions caused by mendelian mutations
US11096956B2 (en) * 2015-12-14 2021-08-24 Stoke Therapeutics, Inc. Antisense oligomers and uses thereof
JP7049248B2 (ja) * 2015-12-14 2022-04-06 コールド スプリング ハーバー ラボラトリー 常染色体優性精神遅滞－５とドラベ症候群の処置のためのアンチセンスオリゴマー
CA3147970A1 (en) * 2019-08-19 2021-02-25 Isabel AZNAREZ Compositions and methods for modulating splicing and protein expression

Also Published As

Publication number Publication date
IL298070A (en) 2023-01-01
JP2023526060A (ja) 2023-06-20
EP4150094A1 (en) 2023-03-22
CO2022017705A2 (es) 2023-02-16
PE20230739A1 (es) 2023-05-03
US20230174984A1 (en) 2023-06-08
AU2021272832A1 (en) 2022-12-15
ECSP22093649A (es) 2023-02-28
CA3178334A1 (en) 2021-11-18
CL2022003145A1 (es) 2023-06-30
WO2021226663A1 (en) 2021-11-18
BR112022022893A2 (pt) 2023-03-14
CN115916977A (zh) 2023-04-04
KR20230009965A (ko) 2023-01-17

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