MX2022013788A - Proceso para la preparacion de verdiperstat. - Google Patents

Proceso para la preparacion de verdiperstat.

Info

Publication number
MX2022013788A
MX2022013788A MX2022013788A MX2022013788A MX2022013788A MX 2022013788 A MX2022013788 A MX 2022013788A MX 2022013788 A MX2022013788 A MX 2022013788A MX 2022013788 A MX2022013788 A MX 2022013788A MX 2022013788 A MX2022013788 A MX 2022013788A
Authority
MX
Mexico
Prior art keywords
verdiperstat
compound
formula
preparation
dimethylamino
Prior art date
Application number
MX2022013788A
Other languages
English (en)
Inventor
Yadagiri R Pendri
Srinivasa Katham
Sreenivas Mende
Chendrasekhar Kedas
Srinivasa Kandiyala
Dhanaraj Chilakala
Original Assignee
Biohaven Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biohaven Therapeutics Ltd filed Critical Biohaven Therapeutics Ltd
Publication of MX2022013788A publication Critical patent/MX2022013788A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Abstract

Se divulga un proceso mejorado para preparar verdiperstat. El proceso incluye las etapas de hacer reaccionar un compuesto que tiene la fórmula (ver Fórmula) o una sal de este, en donde R es igual o diferente y cada uno es independientemente un C1-C5 alquilo con 3-(dimetilamino)acrilonitrilo para obtener un compuesto que tiene la fórmula (ver Fórmula); y convertir el compuesto que tiene la fórmula (ver Fórmula) en verdiperstat.
MX2022013788A 2020-05-06 2021-05-05 Proceso para la preparacion de verdiperstat. MX2022013788A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063021041P 2020-05-06 2020-05-06
PCT/US2021/030766 WO2021226161A1 (en) 2020-05-06 2021-05-05 Process for the preparation of verdiperstat

Publications (1)

Publication Number Publication Date
MX2022013788A true MX2022013788A (es) 2022-11-30

Family

ID=78468382

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022013788A MX2022013788A (es) 2020-05-06 2021-05-05 Proceso para la preparacion de verdiperstat.

Country Status (10)

Country Link
US (1) US20230192702A1 (es)
EP (1) EP4146219A1 (es)
JP (1) JP2023524241A (es)
KR (1) KR20230007453A (es)
CN (1) CN115551511A (es)
AU (1) AU2021267874A1 (es)
CA (1) CA3181917A1 (es)
IL (1) IL297857A (es)
MX (1) MX2022013788A (es)
WO (1) WO2021226161A1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0301232D0 (sv) * 2003-04-25 2003-04-25 Astrazeneca Ab Novel use
MY140748A (en) * 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
US20090054468A1 (en) * 2007-08-23 2009-02-26 Astrazeneca Ab New Use 938
US8946239B2 (en) * 2008-07-10 2015-02-03 Duquesne University Of The Holy Spirit Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
CN108610275A (zh) * 2016-12-09 2018-10-02 中国科学院大连化学物理研究所 一种3-(2-氰基乙烯基)吲哚衍生物的合成方法

Also Published As

Publication number Publication date
EP4146219A1 (en) 2023-03-15
CN115551511A (zh) 2022-12-30
US20230192702A1 (en) 2023-06-22
JP2023524241A (ja) 2023-06-09
AU2021267874A1 (en) 2023-01-19
WO2021226161A1 (en) 2021-11-11
IL297857A (en) 2023-01-01
CA3181917A1 (en) 2021-11-11
KR20230007453A (ko) 2023-01-12

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