MX2022013433A - Dispositivos y metodos de lisis acoustoforetica. - Google Patents

Dispositivos y metodos de lisis acoustoforetica.

Info

Publication number
MX2022013433A
MX2022013433A MX2022013433A MX2022013433A MX2022013433A MX 2022013433 A MX2022013433 A MX 2022013433A MX 2022013433 A MX2022013433 A MX 2022013433A MX 2022013433 A MX2022013433 A MX 2022013433A MX 2022013433 A MX2022013433 A MX 2022013433A
Authority
MX
Mexico
Prior art keywords
microchannel
lysis
methods
devices
acoustophoretic
Prior art date
Application number
MX2022013433A
Other languages
English (en)
Inventor
Peter Paulicka
Jeffrey Jasperse
Original Assignee
Siemens Healthcare Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics Inc
Publication of MX2022013433A publication Critical patent/MX2022013433A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C12N1/066—Lysis of microorganisms by physical processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se describen dispositivos, métodos y sistemas de lisis que incluyen un dispositivo de lisis que comprende un recipiente de muestra que tiene una superficie exterior, un microcanal dentro de los límites de la superficie exterior, un primer puerto que se extiende a través de la superficie exterior hasta el microcanal y un segundo puerto que se extiende a través de la superficie exterior al microcanal; y un transductor acústico unido a la superficie exterior del recipiente de muestra para formar una estructura monolítica, el transductor acústico configurado para emitir ondas acústicas ultrasónicas y/o para inducir fuerzas de cizallamiento en una muestra de sangre dentro del microcanal, rompiendo así las células sanguíneas.
MX2022013433A 2020-04-28 2021-04-26 Dispositivos y metodos de lisis acoustoforetica. MX2022013433A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063016537P 2020-04-28 2020-04-28
PCT/US2021/029119 WO2021222084A1 (en) 2020-04-28 2021-04-26 Acoustophoretic lysis devices and methods

Publications (1)

Publication Number Publication Date
MX2022013433A true MX2022013433A (es) 2022-11-16

Family

ID=78373895

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022013433A MX2022013433A (es) 2020-04-28 2021-04-26 Dispositivos y metodos de lisis acoustoforetica.

Country Status (8)

Country Link
US (2) US11426727B2 (es)
EP (1) EP4143294A4 (es)
JP (1) JP7361228B2 (es)
CN (1) CN115397967A (es)
CA (1) CA3172154C (es)
IL (1) IL297609A (es)
MX (1) MX2022013433A (es)
WO (1) WO2021222084A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12298233B2 (en) 2020-06-11 2025-05-13 Siemens Healthcare Diagnostics Inc. Method and analyzer to correct for unknown interferences in a patient blood sample
WO2022031458A1 (en) 2020-08-03 2022-02-10 Siemens Healthcare Diagnostics Inc. Absorbance spectroscopy analyzer and method of use
MX2023001347A (es) 2020-08-03 2023-02-27 Siemens Healthcare Diagnostics Inc Dispositivos de lisis con un piezo elemento y metodos.
JP7777701B2 (ja) * 2022-06-17 2025-11-28 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 導電性電極を有する音響泳動デバイスおよび方法
CA3258173A1 (en) * 2022-06-30 2024-01-04 Siemens Healthcare Diagnostics Inc. ACOUSTOPHORETIC ANALYSIS DEVICES AND METHODS
EP4431909A1 (en) * 2023-03-16 2024-09-18 Vrije Universiteit Brussel Acoustic resonance in microfluidics

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4854170A (en) 1988-10-12 1989-08-08 Separation Technology, Inc. Apparatus and method for using ultrasound to determine hematocrit
US5652141A (en) 1990-10-26 1997-07-29 Oiagen Gmbh Device and process for isolating nucleic acids from cell suspension
WO1992022818A1 (en) * 1991-06-19 1992-12-23 Abbott Laboratories Rapid determination of glycated hemoglobin
US5371020A (en) 1991-09-19 1994-12-06 Radiometer A/S Method of photometric in vitro determination of the content of an analyte in a sample
US6216538B1 (en) 1992-12-02 2001-04-17 Hitachi, Ltd. Particle handling apparatus for handling particles in fluid by acoustic radiation pressure
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
JP3487699B2 (ja) 1995-11-08 2004-01-19 株式会社日立製作所 超音波処理方法および装置
US6071239A (en) 1997-10-27 2000-06-06 Cribbs; Robert W. Method and apparatus for lipolytic therapy using ultrasound energy
AU750549B2 (en) 1998-03-04 2002-07-18 Lund University System for performing assays on a levitated droplet
DK1086366T3 (da) 1998-06-12 2010-08-09 Radiometer Medical Aps Fremgangsmåde til kvalitetskontrol af et spektrofotometer
US6572830B1 (en) * 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US6100084A (en) 1998-11-05 2000-08-08 The Regents Of The University Of California Micro-sonicator for spore lysis
US6431476B1 (en) 1999-12-21 2002-08-13 Cepheid Apparatus and method for rapid ultrasonic disruption of cells or viruses
FR2791697B1 (fr) 1999-04-01 2003-02-28 Biomerieux Sa Appareil et procede de lyse par ultrasons de cellules biologiques
US6442411B1 (en) 1999-04-21 2002-08-27 Optix, Lp Method for improving calibration of an instrument for non-invasively measuring constituents in arterial blood
FR2812303B1 (fr) 2000-07-27 2002-12-06 Biomerieux Sa Procede de lyse cellulaire de procaryotes ou d'eucaryotes ou de lyse cellulaire simultanee de procaryotes et d'eucaryotes
US7029628B2 (en) 2000-12-28 2006-04-18 Stat-Chem Inc. Portable co-oximeter
SE522801C2 (sv) 2001-03-09 2004-03-09 Erysave Ab Anordning för att separera suspenderade partiklar från en fluid med ultraljud samt metod för sådan separering
US7192557B2 (en) 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US6942169B2 (en) 2001-06-06 2005-09-13 Integrated Sensing Systems Micromachined lysing device and method for performing cell lysis
CN100537600C (zh) 2001-09-17 2009-09-09 孟山都技术公司 增强型蛋白及其应用方法
DE10148916A1 (de) 2001-10-04 2003-04-17 Beatrix Christa Meier Ultraschallvorrichtung
US6739531B2 (en) 2001-10-04 2004-05-25 Cepheid Apparatus and method for rapid disruption of cells or viruses
US6819027B2 (en) 2002-03-04 2004-11-16 Cepheid Method and apparatus for controlling ultrasonic transducer
SE0200860D0 (sv) 2002-03-20 2002-03-20 Monica Almqvist Microfluidic cell and method for sample handling
US20060148064A1 (en) 2002-10-25 2006-07-06 Srivastava Pramod K Apparatus and method for immunotherapy of a cancer through controlled cell lysis
US7338802B2 (en) 2002-10-30 2008-03-04 Radiometer Medical Aps Method of performing calibration and quality control of a sensor and apparatus for performing the method
JP2007516957A (ja) 2003-06-13 2007-06-28 イマルクス セラピューティクス インコーポレーティッド 改変超音波技術を使用する非侵襲性血管内血栓溶解
JP2008506129A (ja) 2004-07-13 2008-02-28 ラジオメーター・メディカル・アー・ペー・エス 基準気体を収容するコンテナ、基準流体のセット、基準流体を収容するカセット、及び、基準流体を含む装置
US7611840B2 (en) * 2004-08-03 2009-11-03 Agency For Science, Technology And Research Method and device for the treatment of biological samples
JP2008527312A (ja) 2004-12-31 2008-07-24 メムズフロウ エイピーエス たとえば細胞溶解のための脈動圧力波の生成
US7704743B2 (en) 2005-03-30 2010-04-27 Georgia Tech Research Corporation Electrosonic cell manipulation device and method of use thereof
KR101157175B1 (ko) 2005-12-14 2012-07-03 삼성전자주식회사 세포 또는 바이러스의 농축 및 용해용 미세유동장치 및방법
EP1800743A1 (en) 2005-12-23 2007-06-27 Nederlandse Organisatie voor Toegepast-Natuuurwetenschappelijk Onderzoek TNO Device for ultrasonically treating a fluid and/or sample
US20080124777A1 (en) 2006-11-29 2008-05-29 Canon U.S. Life Sciences, Inc. Method for releasing genetic material from solid phase
US8169122B1 (en) 2006-12-15 2012-05-01 Dxna Llc Ultra sonic release of DNA or RNA
JP2009082862A (ja) 2007-10-02 2009-04-23 Elekon Kagaku Kk 三交差変超波真空破砕装置
WO2009063198A2 (en) 2007-11-14 2009-05-22 Prokyma Technologies Limited Extraction and purification of biological cells using ultrasound
US9127306B2 (en) 2008-02-15 2015-09-08 Life Technologies Corporation Methods and apparatuses for nucleic acid shearing by sonication
AU2009243090C1 (en) 2008-04-30 2014-03-06 Instrumentation Laboratory Company Hemoglobin based bilirubin reference material
US20100004536A1 (en) 2008-07-03 2010-01-07 Avner Rosenberg Method and apparatus for ultrasound tissue treatment
CN102099679A (zh) * 2008-07-16 2011-06-15 雷迪奥米特医学公司 用于使血液样品溶血和用于测量其至少一个参数的设备
EP2382010A4 (en) 2008-12-24 2014-05-14 Guided Therapy Systems Llc METHOD AND SYSTEMS FOR FAT REDUCTION AND / OR TREATMENT OF CELLULITE
BRPI1014469A2 (pt) 2009-04-14 2017-06-27 Biocartis Sa cavitação induzida hifu com limiar de energia reduzido
US9063136B2 (en) * 2009-08-02 2015-06-23 Qvella Corporation Cell concentration, capture and lysis devices and methods of use thereof
US8518681B2 (en) * 2009-12-04 2013-08-27 Sound Surgical Technologies Llc Selective lysing of cells using ultrasound
KR101155085B1 (ko) * 2009-12-18 2012-06-11 광주과학기술원 세포 용해 장치 및 그 제조 방법
NZ601400A (en) 2010-01-26 2013-11-29 Stem Cells Spin S A Cell homogenate from stem cells derived from growing deer antlers, a method of obtaining it and its use
US10369386B2 (en) * 2010-05-27 2019-08-06 Koninklijke Philips N.V. Ultrasound transducer for selectively generating ultrasound waves and heat
EP2608878A4 (en) * 2010-08-23 2017-11-15 President and Fellows of Harvard College Acoustic waves in microfluidics
US9096823B1 (en) * 2010-08-31 2015-08-04 Sandia Corporation Microfluidic device for acoustic cell lysis
KR101776215B1 (ko) 2010-10-29 2017-09-08 삼성전자 주식회사 세포 파쇄용 마이크로 디바이스 및 이를 이용한 세포 파쇄 방법
US9217132B2 (en) 2011-01-20 2015-12-22 Ibis Biosciences, Inc. Microfluidic transducer
WO2012162133A1 (en) 2011-05-20 2012-11-29 Advandx, Inc. Selective ultrasonic lysis of blood and other biological fluids and tissues
US10702244B2 (en) 2011-06-29 2020-07-07 Sunnybrook Research Institute System and method for controlling focused ultrasound treatment
US20130116459A1 (en) 2011-10-13 2013-05-09 Los Alamos National Security, Llc Method and apparatus for acoustically manipulating biological particles
JP2014530022A (ja) 2011-10-13 2014-11-17 マイクロソニック システムズ インク．Ｍｉｃｒｏｓｏｎｉｃ Ｓｙｓｔｅｍｓ Ｉｎｃ． 核酸鎖の制御されたフラグメント化のための超音波放射を使用した装置及び方法
US9873119B2 (en) 2011-12-28 2018-01-23 Ibis Biosciences, Inc. Multiple- analyte assay device and system
US9279800B2 (en) 2012-01-13 2016-03-08 Alcor Scientific, Inc. Apparatus, method, system for the determination of the aggregation rate of red blood cells
KR20150014925A (ko) 2012-04-16 2015-02-09 바이오로지컬 다이나믹스, 인크. 핵산 시료 제조
FR2990217B1 (fr) 2012-05-03 2016-02-05 Biomerieux Sa Procede d'obtention de peptides
US10564147B2 (en) * 2012-05-25 2020-02-18 The Regents Of The University Of California Microfluidic systems for particle trapping and separation using cavity acoustic transducers
US9278027B2 (en) 2012-07-09 2016-03-08 Alcon Research, Ltd. Rounded-end device, system, and method for preventing posterior capsular opacification
EP2936118B1 (en) 2012-12-20 2023-06-21 Radiometer Medical ApS An apparatus for detecting the concentration of a component in a sample
DE102013200357A1 (de) 2013-01-14 2014-07-31 Robert Bosch Gmbh Kammer zur Aufnahme einer Probe mit integrierter Schneide
WO2014133451A1 (en) 2013-02-28 2014-09-04 Acousort Ab System and method to analyze non-spherical cells
US9675747B2 (en) 2013-03-15 2017-06-13 William L Puskas Methods and systems for improved cavitation efficiency and density, cancer cell destruction, and/or causing a target object to be a cavitation nucleus
US9416776B2 (en) * 2013-03-15 2016-08-16 Siemens Healthcare Diagnostics Inc. Microfluidic distributing device
DE102013215570A1 (de) 2013-08-07 2015-02-12 Robert Bosch Gmbh Verfahren und Vorrichtung zum Aufbereiten einer Zielzellen und Begleitzellen enthaltenden Probe biologischen Materials zum Extrahieren von Nukleinsäuren der Zielzellen
US11092521B2 (en) * 2013-08-21 2021-08-17 Covaris, Inc. Method and system for acoustically treating material
US10799914B2 (en) 2014-06-02 2020-10-13 Luminex Corporation Methods and systems for ultrasonic lysis
US9512421B1 (en) 2014-06-27 2016-12-06 Sandia Corporation Miniature acoustic wave lysis system and uses thereof
FR3027672B1 (fr) 2014-10-24 2018-11-23 Biomerieux Methode et dispositifs de traitement d'echantillons biologiques
WO2016115014A1 (en) 2015-01-12 2016-07-21 Instrumentation Laboratory Company Spatial separation of particles in a particle containing solution for biomedical sensing and detection
EP3268125A4 (en) 2015-03-13 2018-08-15 President and Fellows of Harvard College Determination of cells using amplification
US11097130B2 (en) 2015-12-10 2021-08-24 California Institute Of Technology Targeting cancer cells selectively via resonant harmonic excitation
EP3184624A1 (en) 2015-12-22 2017-06-28 Diagenode S.A. Frequency optimized devices and methods for microfluidic sonication
EP3423156B1 (en) 2016-03-03 2022-10-19 Alma Lasers Ltd. Sonotrode
AU2017266883B2 (en) 2016-05-20 2019-08-15 Instrumentation Laboratory Company Evanescent hemolysis detection
US20200405258A1 (en) 2016-07-15 2020-12-31 The University Of North Carolina At Chapel Hill Methods and systems for using phase change nanodroplets to enhance sonothrombolysis
WO2018017794A1 (en) 2016-07-21 2018-01-25 President And Fellows Of Harvard College Microfluidic sequencing techniques
EP3523026B1 (en) 2016-10-07 2024-09-25 AcouSort AB Method and system for optical or electrical measurements in disperse fluids
WO2018071255A1 (en) 2016-10-13 2018-04-19 Instrumentation Laboratory Company Total protein measurement using whole blood refractometry
US11229809B2 (en) 2017-03-03 2022-01-25 California Institute Of Technology Selective disruption of neoplastic cells via resonant harmonic excitation
US11123575B2 (en) 2017-06-29 2021-09-21 Insightec, Ltd. 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance
JP2021534144A (ja) 2018-08-23 2021-12-09 シワ コーポレーション Ａｇｅ修飾細胞を除去するための、抗カルボキシメチルリシン抗体及び超音波
EP3908403A1 (en) 2019-01-10 2021-11-17 Instrumentation Laboratory Company Ultrasound lysing of whole blood
US11786215B2 (en) 2019-01-23 2023-10-17 Washington University Methods of detecting, measuring, or imaging a concentration or location of a therapeutic agent
US20220133263A1 (en) 2019-03-01 2022-05-05 The Johns Hopkins University Mri-compatible implantable wireless diagnostic and therapeutic ultrasound
US20200355605A1 (en) 2019-03-05 2020-11-12 Optiscan Biomedical Corporation Automated fluid analysis using tunable optical sources
WO2020206281A1 (en) 2019-04-04 2020-10-08 Northwestern University Improved delivery of drug therapy to the cns by ultrasound-based opening of the blood-brain barrier
CA3081116A1 (en) 2019-05-14 2020-11-14 Gliaview Llc Ultra-sound compatible artificial cranial prosthesis with customized platforms
US20210059696A1 (en) 2019-05-24 2021-03-04 Softwave Tissue Regeneration Technologies, Llc Device and methods to treat infections, inflammations and tumors in organs and tissues and to extend the utility of antibiotics
KR102096204B1 (ko) 2019-05-31 2020-04-02 최명석 국소지방 파괴 방법 및 국소지방 파괴용 저장성 용액
MX2023001347A (es) * 2020-08-03 2023-02-27 Siemens Healthcare Diagnostics Inc Dispositivos de lisis con un piezo elemento y metodos.

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