MX2022012828A - Preparación de un degradador selectivo de receptores de estrógeno. - Google Patents

Preparación de un degradador selectivo de receptores de estrógeno.

Info

Publication number
MX2022012828A
MX2022012828A MX2022012828A MX2022012828A MX2022012828A MX 2022012828 A MX2022012828 A MX 2022012828A MX 2022012828 A MX2022012828 A MX 2022012828A MX 2022012828 A MX2022012828 A MX 2022012828A MX 2022012828 A MX2022012828 A MX 2022012828A
Authority
MX
Mexico
Prior art keywords
estrogen receptor
selective estrogen
preparation
receptor degrader
degrader
Prior art date
Application number
MX2022012828A
Other languages
English (en)
Inventor
Ian Scott
Rakesh Kumar Sit
Joseph Robert Pinchman
Kevin Duane Bunker
Peter Qinhua Huang
Sayee Gajanan Hegde
Chad Daniel Hopkins
Aditya Krishnan Unni
John Knight
Shuguang Zhu
Original Assignee
Recurium Ip Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recurium Ip Holdings Llc filed Critical Recurium Ip Holdings Llc
Publication of MX2022012828A publication Critical patent/MX2022012828A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/02—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the alkali- or alkaline earth metals or beryllium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
    • B01J31/122—Metal aryl or alkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

En la presente descripción se describe un método para obtener un degradador selectivo de receptores de estrógeno, y compuestos usados para preparar el degradador selectivo de receptores de estrógeno.
MX2022012828A 2020-04-22 2021-04-21 Preparación de un degradador selectivo de receptores de estrógeno. MX2022012828A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063013686P 2020-04-22 2020-04-22
PCT/US2021/028344 WO2021216671A1 (en) 2020-04-22 2021-04-21 Preparation of an selective estrogen receptor degrader

Publications (1)

Publication Number Publication Date
MX2022012828A true MX2022012828A (es) 2023-01-04

Family

ID=78270064

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022012828A MX2022012828A (es) 2020-04-22 2021-04-21 Preparación de un degradador selectivo de receptores de estrógeno.

Country Status (11)

Country Link
US (1) US20230212118A1 (es)
EP (1) EP4121413A4 (es)
JP (1) JP2023522934A (es)
KR (1) KR20230002950A (es)
CN (1) CN117242055A (es)
AU (1) AU2021259583A1 (es)
CA (1) CA3179331A1 (es)
IL (1) IL297448A (es)
MX (1) MX2022012828A (es)
TW (1) TW202204363A (es)
WO (1) WO2021216671A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220103977A (ko) * 2019-11-04 2022-07-25 리커리엄 아이피 홀딩스, 엘엘씨 에스트로겐 수용체 조절제의 염 및 형태
JP2024502270A (ja) 2020-12-23 2024-01-18 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー エストロゲン受容体調節薬

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1797091A2 (en) * 2004-09-14 2007-06-20 Novartis Vaccines and Diagnostics, Inc. Imidazoquinoline compounds
UA100192C2 (en) * 2008-11-11 2012-11-26 УАЙТ ЭлЭлСи 1-(arylsulfonyl)-4-(piperazin-1-yl)-1h-benzimidazoles as 5-hydroxytryptamine-6 ligands
CA3017388C (en) * 2016-04-01 2024-03-12 Zeno Royalties & Milestones, LLC Estrogen receptor modulators
CN111164063A (zh) * 2017-09-11 2020-05-15 里科瑞尔姆Ip控股有限责任公司 用于制备双环化合物的连续流动方法

Also Published As

Publication number Publication date
JP2023522934A (ja) 2023-06-01
IL297448A (en) 2022-12-01
CN117242055A (zh) 2023-12-15
KR20230002950A (ko) 2023-01-05
WO2021216671A1 (en) 2021-10-28
US20230212118A1 (en) 2023-07-06
CA3179331A1 (en) 2021-10-28
EP4121413A1 (en) 2023-01-25
TW202204363A (zh) 2022-02-01
AU2021259583A1 (en) 2022-11-24
EP4121413A4 (en) 2024-04-17

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