MX2022012828A - Preparation of an selective estrogen receptor degrader. - Google Patents

Preparation of an selective estrogen receptor degrader.

Info

Publication number
MX2022012828A
MX2022012828A MX2022012828A MX2022012828A MX2022012828A MX 2022012828 A MX2022012828 A MX 2022012828A MX 2022012828 A MX2022012828 A MX 2022012828A MX 2022012828 A MX2022012828 A MX 2022012828A MX 2022012828 A MX2022012828 A MX 2022012828A
Authority
MX
Mexico
Prior art keywords
estrogen receptor
selective estrogen
preparation
receptor degrader
degrader
Prior art date
Application number
MX2022012828A
Other languages
Spanish (es)
Inventor
Ian Scott
Rakesh Kumar Sit
Joseph Robert Pinchman
Kevin Duane Bunker
Peter Qinhua Huang
Sayee Gajanan Hegde
Chad Daniel Hopkins
Aditya Krishnan Unni
John Knight
Shuguang Zhu
Original Assignee
Recurium Ip Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recurium Ip Holdings Llc filed Critical Recurium Ip Holdings Llc
Publication of MX2022012828A publication Critical patent/MX2022012828A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/02—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the alkali- or alkaline earth metals or beryllium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
    • B01J31/122—Metal aryl or alkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Described herein is a method for obtaining a selective estrogen receptor degrader, and compounds used in preparing the selective estrogen receptor degrader.
MX2022012828A 2020-04-22 2021-04-21 Preparation of an selective estrogen receptor degrader. MX2022012828A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063013686P 2020-04-22 2020-04-22
PCT/US2021/028344 WO2021216671A1 (en) 2020-04-22 2021-04-21 Preparation of an selective estrogen receptor degrader

Publications (1)

Publication Number Publication Date
MX2022012828A true MX2022012828A (en) 2023-01-04

Family

ID=78270064

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022012828A MX2022012828A (en) 2020-04-22 2021-04-21 Preparation of an selective estrogen receptor degrader.

Country Status (11)

Country Link
US (1) US20230212118A1 (en)
EP (1) EP4121413A4 (en)
JP (1) JP2023522934A (en)
KR (1) KR20230002950A (en)
CN (1) CN117242055A (en)
AU (1) AU2021259583A1 (en)
CA (1) CA3179331A1 (en)
IL (1) IL297448A (en)
MX (1) MX2022012828A (en)
TW (1) TW202204363A (en)
WO (1) WO2021216671A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220389006A1 (en) * 2019-11-04 2022-12-08 Recurium Ip Holdings, Llc Salts and forms of an estrogen receptor modulator
JP2024502270A (en) 2020-12-23 2024-01-18 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー Estrogen receptor modulators

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201807708SA (en) * 2016-04-01 2018-10-30 Zeno Royalties & Milestones Llc Estrogen receptor modulators
IL272875B2 (en) * 2017-09-11 2023-10-01 Recurium Ip Holdings Llc Continuous flow processes for making bicyclic compounds

Also Published As

Publication number Publication date
CA3179331A1 (en) 2021-10-28
JP2023522934A (en) 2023-06-01
TW202204363A (en) 2022-02-01
KR20230002950A (en) 2023-01-05
CN117242055A (en) 2023-12-15
AU2021259583A1 (en) 2022-11-24
EP4121413A4 (en) 2024-04-17
WO2021216671A1 (en) 2021-10-28
EP4121413A1 (en) 2023-01-25
US20230212118A1 (en) 2023-07-06
IL297448A (en) 2022-12-01

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