MX2022004572A - Conjugados farmacologicos de ligandos peptidicos biciclicos. - Google Patents
Conjugados farmacologicos de ligandos peptidicos biciclicos.Info
- Publication number
- MX2022004572A MX2022004572A MX2022004572A MX2022004572A MX2022004572A MX 2022004572 A MX2022004572 A MX 2022004572A MX 2022004572 A MX2022004572 A MX 2022004572A MX 2022004572 A MX2022004572 A MX 2022004572A MX 2022004572 A MX2022004572 A MX 2022004572A
- Authority
- MX
- Mexico
- Prior art keywords
- drug conjugates
- peptide ligand
- ligand drug
- bicyclic peptide
- relates
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201914872A GB201914872D0 (en) | 2019-10-15 | 2019-10-15 | Bicyclic peptide ligand drug conjugates |
| PCT/GB2020/052590 WO2021074622A1 (en) | 2019-10-15 | 2020-10-15 | Bicyclic peptide ligand drug conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022004572A true MX2022004572A (es) | 2022-05-06 |
Family
ID=68619460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022004572A MX2022004572A (es) | 2019-10-15 | 2020-10-15 | Conjugados farmacologicos de ligandos peptidicos biciclicos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20240173422A1 (OSRAM) |
| EP (1) | EP4045089A1 (OSRAM) |
| JP (1) | JP2022552839A (OSRAM) |
| KR (1) | KR20220088416A (OSRAM) |
| CN (1) | CN114901317A (OSRAM) |
| AU (1) | AU2020367325A1 (OSRAM) |
| BR (1) | BR112022007099A2 (OSRAM) |
| CA (1) | CA3154672A1 (OSRAM) |
| GB (1) | GB201914872D0 (OSRAM) |
| IL (1) | IL292113A (OSRAM) |
| MX (1) | MX2022004572A (OSRAM) |
| WO (1) | WO2021074622A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102754019B1 (ko) | 2014-10-29 | 2025-01-14 | 바이시클러드 리미티드 | Mt1-mmp에 특이적인 바이사이클릭 펩타이드 리간드 |
| CN111032678A (zh) | 2017-06-26 | 2020-04-17 | 拜西克尔德有限公司 | 具有可检测部分的双环肽配体和其用途 |
| ES2926195T3 (es) | 2017-08-04 | 2022-10-24 | Bicycletx Ltd | Ligandos peptídicos bicíclicos específicos de CD137 |
| AU2019224659A1 (en) | 2018-02-23 | 2020-10-15 | Bicycletx Limited | Multimeric bicyclic peptide ligands |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| CN113474045A (zh) | 2018-12-21 | 2021-10-01 | 拜斯科技术开发有限公司 | Pd-l1特异性的双环肽配体 |
| US12551567B2 (en) | 2018-12-21 | 2026-02-17 | Bicyclerd Limited | Bicyclic peptide ligands specific for PD-L1 |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| CA3189761A1 (en) | 2020-08-03 | 2022-02-10 | Gemma Mudd | Peptide-based linkers |
| GB202016331D0 (en) * | 2020-10-15 | 2020-12-02 | Bicyclerd Ltd | Bicyclic peptide ligand drug conjugates |
| CN118215672A (zh) * | 2021-06-01 | 2024-06-18 | 南京明德新药研发有限公司 | 多肽偶联药物及其应用 |
| AU2022356942B2 (en) | 2021-09-29 | 2025-07-03 | Conjustar (Zhuhai) Biologics Co., Ltd. | Tricyclic polypeptide conjugated drug and use thereof |
| GB202114279D0 (en) * | 2021-10-06 | 2021-11-17 | Bicycletx Ltd | Bicyclic peptide ligand drug conjugates |
| CN118201627A (zh) * | 2021-10-19 | 2024-06-14 | 西藏海思科制药有限公司 | Nectin-4的双环肽配体及其用途 |
| CN116768978A (zh) * | 2022-03-11 | 2023-09-19 | 上海智肽生物科技有限公司 | Nectin-4靶向肽化合物及其药物偶联物 |
| CN117003830A (zh) * | 2023-08-04 | 2023-11-07 | 湖南中晟全肽生化有限公司 | 靶向Nectin-4的多肽及其用途 |
| CN119701000A (zh) * | 2024-12-25 | 2025-03-28 | 中国人民解放军空军军医大学 | 一类多肽偶联药物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| PT1844337E (pt) | 2005-01-24 | 2014-04-03 | Pepscan Systems Bv | Compostos ligantes, compostos imunogénicos e peptidomiméticos |
| WO2009098450A2 (en) | 2008-02-05 | 2009-08-13 | Medical Research Council | Methods and compositions |
| KR102754019B1 (ko) | 2014-10-29 | 2025-01-14 | 바이시클러드 리미티드 | Mt1-mmp에 특이적인 바이사이클릭 펩타이드 리간드 |
| AU2019224659A1 (en) * | 2018-02-23 | 2020-10-15 | Bicycletx Limited | Multimeric bicyclic peptide ligands |
| WO2019193328A1 (en) * | 2018-04-04 | 2019-10-10 | Bicycletx Limited | Heterotandem bicyclic peptide complexes |
| US11180531B2 (en) * | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
-
2019
- 2019-10-15 GB GB201914872A patent/GB201914872D0/en not_active Ceased
-
2020
- 2020-10-15 CN CN202080071881.XA patent/CN114901317A/zh active Pending
- 2020-10-15 US US17/769,668 patent/US20240173422A1/en active Pending
- 2020-10-15 CA CA3154672A patent/CA3154672A1/en active Pending
- 2020-10-15 AU AU2020367325A patent/AU2020367325A1/en not_active Abandoned
- 2020-10-15 MX MX2022004572A patent/MX2022004572A/es unknown
- 2020-10-15 JP JP2022522669A patent/JP2022552839A/ja active Pending
- 2020-10-15 EP EP20796896.7A patent/EP4045089A1/en not_active Withdrawn
- 2020-10-15 BR BR112022007099A patent/BR112022007099A2/pt not_active Application Discontinuation
- 2020-10-15 WO PCT/GB2020/052590 patent/WO2021074622A1/en not_active Ceased
- 2020-10-15 KR KR1020227011804A patent/KR20220088416A/ko not_active Withdrawn
-
2022
- 2022-04-10 IL IL292113A patent/IL292113A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3154672A1 (en) | 2021-04-22 |
| KR20220088416A (ko) | 2022-06-27 |
| GB201914872D0 (en) | 2019-11-27 |
| EP4045089A1 (en) | 2022-08-24 |
| JP2022552839A (ja) | 2022-12-20 |
| WO2021074622A1 (en) | 2021-04-22 |
| AU2020367325A1 (en) | 2022-05-26 |
| BR112022007099A2 (pt) | 2022-07-05 |
| CN114901317A (zh) | 2022-08-12 |
| US20240173422A1 (en) | 2024-05-30 |
| IL292113A (en) | 2022-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12020552179A1 (en) | Bicyclic peptide ligands specific for nectin-4 | |
| PH12020550929A1 (en) | Bicyclic peptide ligands specific for epha2 | |
| WO2022148974A3 (en) | Bicyclic peptide ligands specific for nk cells | |
| MX2021013669A (es) | Ligandos peptidicos biciclicos especificos para ox40. | |
| BR112022007099A2 (pt) | Conjugados de fármaco de ligante de peptídeo bicíclico | |
| SA520420008B1 (ar) | جزيئات ترابطية ببتيدية ثنائية الحلقات متعددة الوحدات | |
| MX2021006991A (es) | Ligandos peptidicos biciclicos especificos para metaloproteasa tipo 1 de membrana (mt1-mmp). | |
| EA202191651A1 (ru) | Бициклические пептидные лиганды, специфичные к mt1-mmp | |
| ZA202001564B (en) | Anti- folate receptor alpha antibody conjugates and their uses | |
| MX2021002969A (es) | Proteinas de union a nkg2d, cd16, y egfr, ccr4 o pd-l1. | |
| MX2024005855A (es) | Procedimientos para tratar el cancer. | |
| MX2020010444A (es) | Complejos de péptidos bicíclicos en heterotándem. | |
| MX395142B (es) | Marcadores selectivamente desregulados en celulas t reguladoras, infiltrantes de tumores. | |
| GEAP202114828A (en) | Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof | |
| WO2016022994A3 (en) | High affinity pd-1 agents and methods of use | |
| UA88146C2 (ru) | Новые пептиды, которые связываются с рецептором эритропоэтина | |
| MX2022005404A (es) | Compuestos de fijación a il-2r e il-7r dual. | |
| ZA202107947B (en) | Combination therapy with omomyc and an antibody binding pd-1 or ctla-4 for the treatment of cancer | |
| EP4621067A3 (en) | Recombinant modified fibroblast growth factors and therapeutic uses thereof | |
| JOP20230109A1 (ar) | أجسام مضادة ثقيلة السلسلة ترتبط مع مستقبل ألفا فولات | |
| MX2023005624A (es) | Ligandos peptidicos biciclicos especificos para el receptor de transferrina 1 (tfr1). | |
| Błauż et al. | Drug-selected cell line panels for evaluation of the pharmacokinetic consequences of multidrug resistance proteins | |
| CY1123041T1 (el) | Συνδυασμος κανρενοατης και εξενατιδης | |
| BR112017000710A2 (pt) | polipeptídeo isolado, polipeptídeo modificado de revestimento final isolado, composição de matéria, polipeptídeo de fusão isolado, composição farmacêutica, método de tratamento de uma doença inflamatória, uso do polipeptídeo isolado, polinucleotídeo isolado, estrutura de ácido nucleico, e método de determinação da potência de um lote do polipeptídeo isolado | |
| EA202190105A1 (ru) | Бициклические пептидные лиганды, специфичные к нектину-4 |