MX2022002792A - Metodo para la obtencion de organoides intestinales saludables. - Google Patents
Metodo para la obtencion de organoides intestinales saludables.Info
- Publication number
- MX2022002792A MX2022002792A MX2022002792A MX2022002792A MX2022002792A MX 2022002792 A MX2022002792 A MX 2022002792A MX 2022002792 A MX2022002792 A MX 2022002792A MX 2022002792 A MX2022002792 A MX 2022002792A MX 2022002792 A MX2022002792 A MX 2022002792A
- Authority
- MX
- Mexico
- Prior art keywords
- organoids
- intestinal
- intestinal organoids
- cells
- kit
- Prior art date
Links
- 230000000968 intestinal effect Effects 0.000 title abstract 5
- 210000002220 organoid Anatomy 0.000 title abstract 4
- 239000000017 hydrogel Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 108010082117 matrigel Proteins 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3882—Hollow organs, e.g. bladder, esophagus, urether, uterus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2371/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
- C08J2371/02—Polyalkylene oxides
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
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- C12N2537/00—Supports and/or coatings for cell culture characterised by physical or chemical treatment
- C12N2537/10—Cross-linking
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Dispersion Chemistry (AREA)
- Urology & Nephrology (AREA)
- Botany (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Polymers & Plastics (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a un hidrogel biofuncional tridimensional apropiado para la multiplicación de células intestinales aisladas recientemente o congeladas y la formación de organoides intestinales a partir de ellas, que evita el uso de una matriz derivada de manera natural como Matrigel y proporciona organoides intestinales apropiados para aplicaciones clínicas y generado de manera comercialmente factible. La presente invención también se refiere a un kit de partes que contienen dicho hidrogel en combinación con un medio de cultivo adecuado y a un método para hacer organoides y multiplicar células a partir de células intestinales aisladas recientemente o congeladas con dicho kit de part.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19195855.2A EP3789049A1 (en) | 2019-09-06 | 2019-09-06 | Method for obtaining healthy intestinal organoids |
PCT/EP2020/073586 WO2021043606A1 (en) | 2019-09-06 | 2020-08-24 | Method for obtaining healthy intestinal organoids |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022002792A true MX2022002792A (es) | 2022-10-10 |
Family
ID=67875311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022002792A MX2022002792A (es) | 2019-09-06 | 2020-08-24 | Metodo para la obtencion de organoides intestinales saludables. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220296784A1 (es) |
EP (2) | EP3789049A1 (es) |
JP (1) | JP2022546845A (es) |
KR (1) | KR20220060546A (es) |
CN (1) | CN114728097B (es) |
AU (1) | AU2020340509A1 (es) |
BR (1) | BR112022003460A2 (es) |
CA (1) | CA3150317C (es) |
IL (1) | IL291036A (es) |
MX (1) | MX2022002792A (es) |
WO (1) | WO2021043606A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023154930A1 (en) * | 2022-02-14 | 2023-08-17 | Known Medicine Inc. | Three-dimensional cell culture systems and methods |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2466116C (en) * | 2001-11-07 | 2012-04-24 | Universitat Zurich | Synthetic matrix for controlled cell ingrowth and tissue regeneration |
EP2022848A1 (en) | 2007-08-10 | 2009-02-11 | Hubrecht Institut | A method for identifying, expanding, and removing adult stem cells and cancer stem cells |
GB201111244D0 (en) | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
WO2010090513A2 (en) * | 2009-02-03 | 2010-08-12 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells. |
EP2380920A1 (en) | 2010-04-22 | 2011-10-26 | QGel SA | Hydrogel precursor formulation and production process thereof |
CA2859614C (en) | 2011-12-19 | 2020-08-25 | Koninklijke Nederlandse Akademie Van Wetenschappen | A rapid quantitative assay to measure cftr function in a primary intestinal culture model |
CN105358677B (zh) * | 2013-03-14 | 2018-06-15 | 布里格海姆妇女医院公司 | 用于上皮干细胞扩增和培养的组合物和方法 |
JP6796059B2 (ja) | 2014-09-12 | 2020-12-02 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Wntシグナリングアゴニスト分子 |
WO2017036533A1 (en) | 2015-09-03 | 2017-03-09 | Ecole Polytechnique Federale De Lausanne (Epfl) | Three-dimensional hydrogels for culturing adult epithelial stem cells and organoids |
EP3356516B1 (en) * | 2015-10-02 | 2021-11-10 | Baylor College of Medicine | Cultivation of human noroviruses |
JP7042252B2 (ja) * | 2016-07-27 | 2022-03-25 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 架橋密度の勾配を有するポリマー足場を作出するための方法 |
EP3275997A1 (en) * | 2016-07-28 | 2018-01-31 | QGel SA | Hydrogel precursor formulation and the use thereof |
EP3494207A4 (en) | 2016-08-03 | 2020-04-01 | Wake Forest University Health Sciences | CANCER MODELING PLATFORMS AND METHODS FOR THEIR USE |
CA3055914A1 (en) | 2017-03-09 | 2018-09-13 | Georgia Tech Research Corporation | Synthetic hydrogel carriers for cellular structures, generation of organoids, and treatment of tissue injury |
-
2019
- 2019-09-06 EP EP19195855.2A patent/EP3789049A1/en active Pending
-
2020
- 2020-08-24 MX MX2022002792A patent/MX2022002792A/es unknown
- 2020-08-24 US US17/640,681 patent/US20220296784A1/en active Pending
- 2020-08-24 AU AU2020340509A patent/AU2020340509A1/en active Pending
- 2020-08-24 BR BR112022003460A patent/BR112022003460A2/pt unknown
- 2020-08-24 KR KR1020227011345A patent/KR20220060546A/ko unknown
- 2020-08-24 JP JP2022515064A patent/JP2022546845A/ja active Pending
- 2020-08-24 EP EP20757611.7A patent/EP4025266B1/en active Active
- 2020-08-24 WO PCT/EP2020/073586 patent/WO2021043606A1/en unknown
- 2020-08-24 CN CN202080062803.3A patent/CN114728097B/zh active Active
- 2020-08-24 CA CA3150317A patent/CA3150317C/en active Active
-
2022
- 2022-03-01 IL IL291036A patent/IL291036A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2020340509A1 (en) | 2022-04-21 |
EP4025266A1 (en) | 2022-07-13 |
EP4025266B1 (en) | 2024-07-31 |
US20220296784A1 (en) | 2022-09-22 |
EP3789049A1 (en) | 2021-03-10 |
CN114728097A (zh) | 2022-07-08 |
IL291036A (en) | 2022-05-01 |
BR112022003460A2 (pt) | 2022-05-24 |
CA3150317C (en) | 2024-06-25 |
CN114728097B (zh) | 2024-01-30 |
KR20220060546A (ko) | 2022-05-11 |
WO2021043606A1 (en) | 2021-03-11 |
CA3150317A1 (en) | 2021-03-11 |
JP2022546845A (ja) | 2022-11-09 |
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