MX2022002451A - Metodos para el tratamiento de la enfermedad cln2 en sujetos pediatricos. - Google Patents
Metodos para el tratamiento de la enfermedad cln2 en sujetos pediatricos.Info
- Publication number
- MX2022002451A MX2022002451A MX2022002451A MX2022002451A MX2022002451A MX 2022002451 A MX2022002451 A MX 2022002451A MX 2022002451 A MX2022002451 A MX 2022002451A MX 2022002451 A MX2022002451 A MX 2022002451A MX 2022002451 A MX2022002451 A MX 2022002451A
- Authority
- MX
- Mexico
- Prior art keywords
- subject
- methods
- disease
- cln2 disease
- cln2
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
- C12Y304/14009—Tripeptidyl-peptidase I (3.4.14.9)
Abstract
Se proporcionan aquí métodos para tratar la enfermedad de lipofuscinosis neuronal ceroidea (CLN2) en un sujeto menor de 3 años de edad. En modalidades ejemplares, el método comprende administrar al sujeto una formulación que comprende tripeptidil peptidasa-1 humana recombinante (rhTPP1) en una cantidad efectiva para tratar la enfermedad CLN2 en el sujeto. También se proporcionan métodos para retrasar la aparición de la enfermedad CLN2, o un síntoma de la misma, en un sujeto menor de 3 años. En modalidades ejemplares, el método comprende administrar al sujeto una formulación que comprende tripeptidil peptidasa-1 humana recombinante (rhTPP1) en una cantidad efectiva para retrasar la aparición de la enfermedad o síntoma de CLN2 en el sujeto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962893535P | 2019-08-29 | 2019-08-29 | |
PCT/US2020/048704 WO2021042020A1 (en) | 2019-08-29 | 2020-08-31 | Methods for treating cln2 disease in pediatric subjects |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022002451A true MX2022002451A (es) | 2022-06-02 |
Family
ID=72470612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022002451A MX2022002451A (es) | 2019-08-29 | 2020-08-31 | Metodos para el tratamiento de la enfermedad cln2 en sujetos pediatricos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US20220273775A1 (es) |
EP (1) | EP4021575A1 (es) |
JP (1) | JP2022546042A (es) |
KR (1) | KR20220054375A (es) |
CN (1) | CN114828960A (es) |
AR (1) | AR119871A1 (es) |
AU (1) | AU2020336984A1 (es) |
BR (1) | BR112022003598A2 (es) |
CA (1) | CA3152521A1 (es) |
CL (1) | CL2022000496A1 (es) |
HR (1) | HRP20220370A1 (es) |
IL (1) | IL290763A (es) |
MX (1) | MX2022002451A (es) |
TW (1) | TW202122106A (es) |
WO (1) | WO2021042020A1 (es) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6302685B1 (en) | 1997-09-16 | 2001-10-16 | University Of Medicine And Dentistry Of New Jersey | Human lysosomal protein and methods of its use |
US20020006400A1 (en) * | 2000-05-11 | 2002-01-17 | Peter Lobel | Recombinant human CLN2 protein and methods of its production and use |
US7442372B2 (en) | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
US20140377244A1 (en) | 2011-12-23 | 2014-12-25 | Shire Human Genetic Therapies, Inc. | Stable formulations for cns delivery of arylsulfatase a |
TWI752907B (zh) * | 2015-05-08 | 2022-01-21 | 美商拜奧馬林製藥公司 | 用於治療cln2疾病之tpp1調配物及方法 |
CN108601771B (zh) * | 2015-10-23 | 2023-02-21 | 衣阿华大学研究基金会 | 使用基因疗法以推迟疾病发生和发展同时提供认知保护来治疗神经变性疾病的方法 |
MX2021005517A (es) * | 2018-11-14 | 2021-06-18 | Regenxbio Inc | Terapia genica para lipofuscinosis neuronal ceroidea. |
-
2020
- 2020-08-31 JP JP2022513165A patent/JP2022546042A/ja active Pending
- 2020-08-31 CN CN202080068971.3A patent/CN114828960A/zh active Pending
- 2020-08-31 BR BR112022003598A patent/BR112022003598A2/pt unknown
- 2020-08-31 AR ARP200102442A patent/AR119871A1/es unknown
- 2020-08-31 US US17/638,029 patent/US20220273775A1/en active Pending
- 2020-08-31 AU AU2020336984A patent/AU2020336984A1/en active Pending
- 2020-08-31 MX MX2022002451A patent/MX2022002451A/es unknown
- 2020-08-31 EP EP20771408.0A patent/EP4021575A1/en active Pending
- 2020-08-31 HR HRP20220370AA patent/HRP20220370A1/hr unknown
- 2020-08-31 WO PCT/US2020/048704 patent/WO2021042020A1/en unknown
- 2020-08-31 KR KR1020227010387A patent/KR20220054375A/ko unknown
- 2020-08-31 TW TW109129724A patent/TW202122106A/zh unknown
- 2020-08-31 CA CA3152521A patent/CA3152521A1/en active Pending
-
2022
- 2022-02-21 IL IL290763A patent/IL290763A/en unknown
- 2022-02-28 CL CL2022000496A patent/CL2022000496A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20220370A1 (hr) | 2022-09-16 |
EP4021575A1 (en) | 2022-07-06 |
CL2022000496A1 (es) | 2022-10-21 |
US20220273775A1 (en) | 2022-09-01 |
AR119871A1 (es) | 2022-01-19 |
CN114828960A (zh) | 2022-07-29 |
WO2021042020A1 (en) | 2021-03-04 |
TW202122106A (zh) | 2021-06-16 |
IL290763A (en) | 2022-04-01 |
BR112022003598A2 (pt) | 2022-05-24 |
KR20220054375A (ko) | 2022-05-02 |
CA3152521A1 (en) | 2021-03-04 |
AU2020336984A1 (en) | 2022-03-10 |
JP2022546042A (ja) | 2022-11-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2020047462A3 (en) | Methods of treating aging-related disorders | |
Karst et al. | Pressure pain threshold and needle acupuncture in chronic tension-type headache–a double-blind placebo-controlled study | |
EP4327873A3 (en) | Tpp1 formulations and methods for treating cln2 disease | |
Gamit et al. | The effect of stretching exercise on primary dysmenorrhea in adult girls | |
WO2005034843A3 (en) | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders | |
CA2986891C (en) | Compositions for use in treating parkinson's disease and related disorders | |
WO2008133928A3 (en) | Mucin glycoproteins and their use for treatment of epithelial lesions and mucin dependent disorders | |
EA201891507A1 (ru) | Кислая альфа-глюкозидаза усиленного действия для лечения болезни помпе | |
WO2006014159A3 (en) | Methods of using regenerative cells in the treatment of musculoskeletal disorders | |
MX2021010058A (es) | Formulaciones de rapamicina tópicas y su uso en el tratamiento de angiofibromas faciales y otros trastornos de la piel. | |
WO2008157747A8 (en) | Use of inhibition of exonuclease 1 in methods for therapy and diagnostic of neurodegenerative diseases, eye diseases, and mitochondrial disorders | |
WO2006022612A3 (en) | Methods of using regenerative cells in the treatment of stroke and related diseases and disorders | |
WO2005009217A3 (en) | Diagnosis of pre-cancerous conditions using pcdgf agents | |
MX2022002451A (es) | Metodos para el tratamiento de la enfermedad cln2 en sujetos pediatricos. | |
Boyaci et al. | Comparison of the short-term effectiveness of short-wave diathermy treatment in patients with carpal tunnel syndrome: a randomized controlled trial | |
MX367580B (es) | El uso de lapatinib o una sal o composición farmacéuticamente aceptable del mismo para el tratamiento del cáncer. | |
Kawecki et al. | Computerized planimetry evaluation of hyperbaric oxygen therapy in the treatment of diabetic foot | |
WO2016081296A3 (en) | Topical medicament for skin and mucosal injuries associated with epidermolisis bullosa | |
MX2020005809A (es) | Composicion topica oftalmica para tratar enfermedades del segmento posterior del ojo. | |
WO2019010301A8 (en) | Treatment of heart disease by inhibition of the action of muscle a-kinase anchoring protein (makap) | |
WO2022271810A3 (en) | Bicyclic peptidyl pan-ras inhibitors | |
WO2020061067A8 (en) | Compositions and methods for treating bone injury | |
ELsehrawy et al. | Extracorporeal shock wave therapy versus low-level laser therapy in the management of chronic plantar fasciitis | |
MX2020001217A (es) | Metodos de tratamiento de sintomas de gastroparesia usando velusetrag. | |
De la Cruz-Torres | Ultrasound-guided percutaneous neuromodulation in chronic lateral elbow pain |