MX2022002121A - Produccion de cannabinoides. - Google Patents
Produccion de cannabinoides.Info
- Publication number
- MX2022002121A MX2022002121A MX2022002121A MX2022002121A MX2022002121A MX 2022002121 A MX2022002121 A MX 2022002121A MX 2022002121 A MX2022002121 A MX 2022002121A MX 2022002121 A MX2022002121 A MX 2022002121A MX 2022002121 A MX2022002121 A MX 2022002121A
- Authority
- MX
- Mexico
- Prior art keywords
- cannabinoids
- production
- enzyme
- butiryl
- dvas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01034—Hydroxymethylglutaryl-CoA reductase (NADPH) (1.1.1.34)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/03—Oxidoreductases acting on the CH-CH group of donors (1.3) with oxygen as acceptor (1.3.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y121/00—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21)
- C12Y121/03—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with oxygen as acceptor (1.21.3)
- C12Y121/03007—Tetrahydrocannabinolic acid synthase (1.21.3.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y121/00—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21)
- C12Y121/03—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with oxygen as acceptor (1.21.3)
- C12Y121/03008—Cannabidiolic acid synthase (1.21.3.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/0101—(2E,6E)-Farnesyl diphosphate synthase (2.5.1.10), i.e. geranyltranstransferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/08—Transferases for other substituted phosphate groups (2.7.8)
- C12Y207/08007—Holo-[acyl-carrier-protein] synthase (2.7.8.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y404/00—Carbon-sulfur lyases (4.4)
- C12Y404/01—Carbon-sulfur lyases (4.4.1)
- C12Y404/01026—Olivetolic acid cyclase (4.4.1.26)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente divulgación se refiere a la producción de cannabinoides en microorganismos recombinantes o en sistemas libres de células usando una combinación de enzimas, que incluye, entre otras, una enzima PKS, una enzima npgA, una cs-OLAS-1, una pp-DVAS- 1, una cs-HEX-1 y/o butiril sintasa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962888738P | 2019-08-19 | 2019-08-19 | |
PCT/US2020/046837 WO2021034847A1 (en) | 2019-08-19 | 2020-08-18 | Production of cannabinoids |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022002121A true MX2022002121A (es) | 2022-07-27 |
Family
ID=72292671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022002121A MX2022002121A (es) | 2019-08-19 | 2020-08-18 | Produccion de cannabinoides. |
Country Status (6)
Country | Link |
---|---|
US (1) | US20220403346A1 (es) |
EP (1) | EP4017972A1 (es) |
AU (1) | AU2020333745A1 (es) |
CA (1) | CA3148628A1 (es) |
MX (1) | MX2022002121A (es) |
WO (1) | WO2021034847A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020176547A1 (en) | 2019-02-25 | 2020-09-03 | Ginkgo Bioworks, Inc. | Biosynthesis of cannabinoids and cannabinoid precursors |
JP2024501517A (ja) * | 2020-12-18 | 2024-01-12 | デビュー バイオテクノロジー, インコーポレイテッド | 無細胞化学物質生産のための多用途連続製造プラットフォーム |
CN114657078B (zh) * | 2022-01-27 | 2024-04-02 | 森瑞斯生物科技(深圳)有限公司 | 一种高产大麻二酚酸的酿酒酵母菌株构建方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016010827A1 (en) | 2014-07-14 | 2016-01-21 | Librede Inc. | Production of cannabinoids in yeast |
JP2020530308A (ja) * | 2017-07-12 | 2020-10-22 | バイオメディキャン, インコーポレイテッド | 酵母におけるカンナビノイドの生成 |
-
2020
- 2020-08-18 CA CA3148628A patent/CA3148628A1/en active Pending
- 2020-08-18 EP EP20764875.9A patent/EP4017972A1/en active Pending
- 2020-08-18 WO PCT/US2020/046837 patent/WO2021034847A1/en unknown
- 2020-08-18 MX MX2022002121A patent/MX2022002121A/es unknown
- 2020-08-18 AU AU2020333745A patent/AU2020333745A1/en not_active Abandoned
- 2020-08-18 US US17/636,322 patent/US20220403346A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2021034847A1 (en) | 2021-02-25 |
CA3148628A1 (en) | 2021-02-25 |
EP4017972A1 (en) | 2022-06-29 |
US20220403346A1 (en) | 2022-12-22 |
AU2020333745A1 (en) | 2022-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022002121A (es) | Produccion de cannabinoides. | |
MX2019013331A (es) | Sistemas de produccion recombinante para policetidos prenilados de la familia de los cannabinoides. | |
WO2018124440A3 (ko) | 신규한 이소프로필말레이트 신타제 변이체 및 이를 이용한 l-류신의 생산 방법 | |
BR112019002941A2 (pt) | processo para preparar uma bebida ou componente de bebida, bebida ou componente de bebida, e uso de uma bebida | |
EP4219704A3 (en) | Aprl-clade protease variants and uses thereof | |
GB2459756B (en) | Enhanced ABE fermentation with high yielding butanol tolerant Clostridium strains | |
MX2016001315A (es) | Variantes de enzimas. | |
IN2012DN03186A (es) | ||
MX2015016379A (es) | Produccion de diterpeno extracelular. | |
AU2012353654A8 (en) | Modified microorganisms and methods of making butadiene using same | |
EP2150615A4 (en) | PROCESS FOR PRODUCING CELLULASE AND HEMICELLULASE HAVING HIGH HYDROLYTIC ACTIVITY | |
UA106372C2 (en) | Enzymatic complex | |
WO2016071505A9 (en) | Microbial production of the flavonoids garbanzol, resokaempferol and fisetin | |
WO2017076421A9 (en) | Solubilization of msw with blend enzymes | |
WO2018203947A3 (en) | MODIFIED BIOSYNTHESIS PATHWAYS FOR FERMENTATION TYRAMINE PRODUCTION | |
MY189867A (en) | Solubilization of msw with blend enzymes | |
AU2015212749A8 (en) | Protein | |
WO2018226170A3 (en) | MUTANT STRAIN OF CLOSTRIDIUM THERMOCELLUM FOR THE PRODUCTION OF CELLULASE AND XYLANASE AND PREPARATION METHOD THEREOF | |
MX2022012110A (es) | Sistemas crispr clase ii tipo ii. | |
MY186338A (en) | Method for producing ?-hydromuconic acid | |
PH12019500096A1 (en) | Leuconostoc mesenteroides cjlm119 strain producing reduced amount of gas, and kimchi production method using same | |
WO2020132027A3 (en) | Cell-free production of allulose | |
WO2018226171A3 (en) | MUTANT STRAIN ASPERGILLUS ACULEATUS FOR THE PRODUCTION OF CELLULASE AND XYLANASE AND PROCESS FOR PREPARING THE SAME | |
MX2019004002A (es) | Inhibidor del crecimiento de bacterias, hongos y levaduras que contiene alulosa. | |
PH12021550347A1 (en) | MICROORGANISM FOR PRODUCING L-AMINO ACID WITH ENHANCED ACTIVITY OF a-GLUCOSIDASE AND METHOD FOR PRODUCING L-AMINO ACID USING THE SAME |