MX2022000498A - Polimorfos de (r)-n-(5-(5-isopropil-1,2,4-oxadiazol-3-il)-2,3-dihi dro-1h-inden-1-il) -2-metil-2h- tetrazol-5-carboxamida. - Google Patents
Polimorfos de (r)-n-(5-(5-isopropil-1,2,4-oxadiazol-3-il)-2,3-dihi dro-1h-inden-1-il) -2-metil-2h- tetrazol-5-carboxamida.Info
- Publication number
- MX2022000498A MX2022000498A MX2022000498A MX2022000498A MX2022000498A MX 2022000498 A MX2022000498 A MX 2022000498A MX 2022000498 A MX2022000498 A MX 2022000498A MX 2022000498 A MX2022000498 A MX 2022000498A MX 2022000498 A MX2022000498 A MX 2022000498A
- Authority
- MX
- Mexico
- Prior art keywords
- oxadiazol
- polymorphs
- tetrazole
- carboxamide
- isopropyl
- Prior art date
Links
- CJCOMBSXEZCBLF-CYBMUJFWSA-N 2-methyl-N-[(1R)-5-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]tetrazole-5-carboxamide Chemical compound C(C)(C)C1=NC(=NO1)C=1C=C2CC[C@H](C2=CC=1)NC(=O)C=1N=NN(N=1)C CJCOMBSXEZCBLF-CYBMUJFWSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962875355P | 2019-07-17 | 2019-07-17 | |
| PCT/US2020/042390 WO2021011809A1 (en) | 2019-07-17 | 2020-07-16 | Polymorphs of (r)-n-(5-(5-isopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-2-methyl-2h-tetrazole-5-carboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022000498A true MX2022000498A (es) | 2022-02-03 |
Family
ID=71995105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022000498A MX2022000498A (es) | 2019-07-17 | 2020-07-16 | Polimorfos de (r)-n-(5-(5-isopropil-1,2,4-oxadiazol-3-il)-2,3-dihi dro-1h-inden-1-il) -2-metil-2h- tetrazol-5-carboxamida. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20220274969A1 (https=) |
| EP (1) | EP3999181B1 (https=) |
| JP (1) | JP2022542803A (https=) |
| KR (1) | KR20220082803A (https=) |
| CN (1) | CN114667283B (https=) |
| AU (1) | AU2020315433A1 (https=) |
| BR (1) | BR112022000523A2 (https=) |
| CA (1) | CA3144974A1 (https=) |
| CL (1) | CL2022000089A1 (https=) |
| ES (1) | ES2982707T3 (https=) |
| IL (1) | IL289881A (https=) |
| MX (1) | MX2022000498A (https=) |
| NZ (1) | NZ784931A (https=) |
| PH (1) | PH12022550084A1 (https=) |
| TW (1) | TW202116764A (https=) |
| WO (1) | WO2021011809A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019144041A1 (en) | 2018-01-19 | 2019-07-25 | Cytokinetics, Inc. | Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors |
| JP7610985B2 (ja) | 2018-06-26 | 2025-01-09 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| JP7438148B2 (ja) | 2018-06-26 | 2024-02-26 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| WO2024179422A1 (zh) * | 2023-03-02 | 2024-09-06 | 苏州科睿思制药有限公司 | Aficamten的共晶及其制备方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE552236T1 (de) * | 2003-01-14 | 2012-04-15 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren zur behandlung von herzinsuffizienz |
| WO2007078815A2 (en) * | 2005-12-16 | 2007-07-12 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| WO2019144041A1 (en) * | 2018-01-19 | 2019-07-25 | Cytokinetics, Inc. | Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors |
-
2020
- 2020-07-16 BR BR112022000523A patent/BR112022000523A2/pt unknown
- 2020-07-16 PH PH1/2022/550084A patent/PH12022550084A1/en unknown
- 2020-07-16 NZ NZ784931A patent/NZ784931A/en unknown
- 2020-07-16 MX MX2022000498A patent/MX2022000498A/es unknown
- 2020-07-16 JP JP2022502217A patent/JP2022542803A/ja active Pending
- 2020-07-16 CA CA3144974A patent/CA3144974A1/en active Pending
- 2020-07-16 ES ES20753564T patent/ES2982707T3/es active Active
- 2020-07-16 TW TW109124109A patent/TW202116764A/zh unknown
- 2020-07-16 WO PCT/US2020/042390 patent/WO2021011809A1/en not_active Ceased
- 2020-07-16 AU AU2020315433A patent/AU2020315433A1/en not_active Abandoned
- 2020-07-16 EP EP20753564.2A patent/EP3999181B1/en active Active
- 2020-07-16 US US17/627,590 patent/US20220274969A1/en active Pending
- 2020-07-16 KR KR1020227002979A patent/KR20220082803A/ko not_active Ceased
- 2020-07-16 CN CN202080059957.7A patent/CN114667283B/zh active Active
-
2022
- 2022-01-12 CL CL2022000089A patent/CL2022000089A1/es unknown
- 2022-01-16 IL IL289881A patent/IL289881A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20220274969A1 (en) | 2022-09-01 |
| IL289881A (en) | 2022-03-01 |
| EP3999181B1 (en) | 2024-05-29 |
| CN114667283B (zh) | 2023-12-26 |
| CN114667283A (zh) | 2022-06-24 |
| KR20220082803A (ko) | 2022-06-17 |
| AU2020315433A1 (en) | 2022-03-03 |
| JP2022542803A (ja) | 2022-10-07 |
| NZ784931A (en) | 2025-03-28 |
| PH12022550084A1 (en) | 2023-04-12 |
| ES2982707T3 (es) | 2024-10-17 |
| CA3144974A1 (en) | 2021-01-21 |
| EP3999181A1 (en) | 2022-05-25 |
| TW202116764A (zh) | 2021-05-01 |
| EP3999181C0 (en) | 2024-05-29 |
| WO2021011809A1 (en) | 2021-01-21 |
| BR112022000523A2 (pt) | 2022-03-03 |
| CL2022000089A1 (es) | 2022-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12022550123A1 (en) | Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide | |
| MX2022000498A (es) | Polimorfos de (r)-n-(5-(5-isopropil-1,2,4-oxadiazol-3-il)-2,3-dihi dro-1h-inden-1-il) -2-metil-2h- tetrazol-5-carboxamida. | |
| PH12016501440A1 (en) | Novel heterocyclic compounds | |
| EP4324525A3 (en) | Hydrochloride salt form for ezh2 inhibition | |
| NZ725008A (en) | Compounds for treating spinal muscular atrophy | |
| TW201613880A (en) | Crystalline solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole | |
| MX2020011478A (es) | Formas solidas de 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il) -1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida y sus composiciones farmaceuticas y usos. | |
| PH12020500105A1 (en) | Bicyclic ketone compounds and methods of use thereof | |
| MX2020010866A (es) | Compuestos novedosos utiles como abridores del canal de potasio. | |
| MY198265A (en) | Isoxazole Derivatives as Nuclear Receptor Agonists and uses Thereof | |
| PH12022550328A1 (en) | Compositions comprising tigolaner for controlling parasites | |
| JOP20220093A1 (ar) | تركيبة صيدلانية تشتمل على سيليكسيباغ | |
| PH12017500029A1 (en) | 4,5-dihydroisoxazole derivatives as nampt inhibitors | |
| MX2024010625A (es) | Compuestos antibioticos, metodos de fabricacion de los mismos, composiciones farmaceuticas conteniendo los mismos y usos de los mismos. | |
| GEAP202115310A (en) | CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS AND THEIR USE | |
| PH12020550125A1 (en) | Crystalline forms of 3-substituted 1,2,4-oxadiazole | |
| BR112017012646A2 (pt) | Formas sólidas compreendendo (1e, 4e)-2-amino- n,n-dipropil-8-(4-(pirrolidina-1-carbonil) fenil)-3h- benzo[b]azepina-4-carboxamida, composições das mesmas, e uso das mesmas | |
| PH12021551396A1 (en) | Active ester derivatives of testosterone, compositions and uses thereof | |
| WO2020049598A3 (en) | Apalutamide polymorphs | |
| MX393915B (es) | Nuevas formulaciones orales de belinostat. | |
| PH12021552032A1 (en) | Novel compounds and pharmaceutical compositions thereof for the treatment of diseases | |
| JOP20200025A1 (ar) | مركبات جديدة تنشط مسار Nrf2 | |
| IL288577A (en) | Formulations of (s)-3-amino-6-methoxy-n-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide | |
| HK40074727A (en) | Polymorphs of (r)-n-(5-(5-isopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-2-methyl-2h-tetrazole-5-carboxamide | |
| PH12018502523B1 (en) | Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent |