MX2021014753A - Metodos y composiciones mejorados para la produccion incrementada de arn de doble cadena. - Google Patents

Metodos y composiciones mejorados para la produccion incrementada de arn de doble cadena.

Info

Publication number
MX2021014753A
MX2021014753A MX2021014753A MX2021014753A MX2021014753A MX 2021014753 A MX2021014753 A MX 2021014753A MX 2021014753 A MX2021014753 A MX 2021014753A MX 2021014753 A MX2021014753 A MX 2021014753A MX 2021014753 A MX2021014753 A MX 2021014753A
Authority
MX
Mexico
Prior art keywords
compositions
double stranded
stranded rna
improved methods
dsrna
Prior art date
Application number
MX2021014753A
Other languages
English (en)
Inventor
Anil Kumar
Original Assignee
Rnaissance Ag Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rnaissance Ag Llc filed Critical Rnaissance Ag Llc
Publication of MX2021014753A publication Critical patent/MX2021014753A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención provee métodos y composiciones para la producción mejorada de grandes cantidades de ARN de doble cadena no encapsidado (ARNdc) in vivo. Los métodos y composiciones descritos, que comprenden la coexpresión de genes que codifican la orotato fosporribosiltransferasa, la proteína de la cubierta del bacteriófago y el ARNdc producen una mejora significativa sobre los métodos in vivo actuales para producir ARNdc no encapsidado.
MX2021014753A 2019-05-30 2020-05-29 Metodos y composiciones mejorados para la produccion incrementada de arn de doble cadena. MX2021014753A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962854843P 2019-05-30 2019-05-30
PCT/US2020/035357 WO2020243593A1 (en) 2019-05-30 2020-05-29 Improved methods and compositions for increased double stranded rna production

Publications (1)

Publication Number Publication Date
MX2021014753A true MX2021014753A (es) 2022-04-06

Family

ID=73554194

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021014753A MX2021014753A (es) 2019-05-30 2020-05-29 Metodos y composiciones mejorados para la produccion incrementada de arn de doble cadena.

Country Status (8)

Country Link
US (1) US20220307038A1 (es)
EP (1) EP3975695A4 (es)
AU (1) AU2020283038A1 (es)
BR (1) BR112021024175A2 (es)
CA (1) CA3142362A1 (es)
IL (1) IL288543A (es)
MX (1) MX2021014753A (es)
WO (1) WO2020243593A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024103025A1 (en) * 2022-11-11 2024-05-16 Rnaissance Ag Llc Fermentation based method for double stranded rna production

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6545676B2 (ja) * 2013-11-14 2019-07-17 スカラブ ゲノミクス， エルエルシー 改善された代謝能力を有する細菌
SG11201807478QA (en) 2016-03-15 2018-09-27 Apse Inc Methods and compositions for increased double stranded rna production

Also Published As

Publication number Publication date
WO2020243593A1 (en) 2020-12-03
IL288543A (en) 2022-02-01
EP3975695A4 (en) 2023-07-19
US20220307038A1 (en) 2022-09-29
BR112021024175A2 (pt) 2022-04-12
CA3142362A1 (en) 2020-12-03
AU2020283038A1 (en) 2022-01-06
EP3975695A1 (en) 2022-04-06

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